A5040958247- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Coronary Artery Anomalies
- Vascular anomalies and interventions
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Cardiovascular Issues in Pregnancy
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Congenital heart defects research
- Cardiac Structural Anomalies and Repair
- Tracheal and airway disorders
- Cardiac Ischemia and Reperfusion
- Congenital Diaphragmatic Hernia Studies
- Receptor Mechanisms and Signaling
- Cardiovascular Conditions and Treatments
- Renal and Vascular Pathologies
- Cardiovascular and Diving-Related Complications
- Nitric Oxide and Endothelin Effects
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
Tokushima University
2015-2025
Tokushima University Hospital
2016-2024
Japan Pediatric Society
2013
Biologie des maladies cardiovasculaires
2013
Cambridge University Press
2010
University of Leicester
2001-2008
Tokushima Hospital
2008
Pediatrics and Genetics
1999
Kagawa National Children's Hospital
1998
Kagoshima University
1993
Few studies with sufficient statistical power have shown the association of z score coronary arterial internal diameter events (CE) in patients Kawasaki disease (KD) artery aneurysms (CAA).To clarify time-dependent CE occurrence KD CAA.This multicenter, collaborative retrospective cohort study 44 participating institutions included 1006 younger than 19 years who received a angiography between 1992 and 2011.The CE, including thrombosis, stenosis, obstruction, acute ischemic events,...
Arterial ATP-sensitive K + (K ATP ) channels are critical regulators of vascular tone, forming a focal point for signaling by many vasoactive transmitters that alter smooth muscle contractility and so blood flow. Clinically, these form the target antianginal antihypertensive drugs, their genetic disruption leads to hypertension sudden cardiac death through coronary vasospasm. However, whereas biochemical basis channel modulation is well-studied, little known about structural or spatial...
We used whole-cell patch clamp to investigate steady-state activation of ATP-sensitive K+ channels (KATP) rat arterial smooth muscle by protein kinase A (PKA) and the pathway which angiotensin II (Ang II) inhibits these channels. Rp-cAMPS, an inhibitor PKA, did not affect KATP currents activated pinacidil when intracellular solution contained 0.1 mM ATP. However, ATP was increased 1.0 mM, inhibition PKA reduced current, while phosphatase calyculin caused a small increase in current. Ang (100...
Background Coronary arterial aneurysms (CAAs) associated with Kawasaki disease (KD) significantly affect prognosis. However, the clinical course of CAAs and factors CAA regression have not been well analyzed. Methods Results The cohort Z-Score 2nd Project Stage study, a multicenter, retrospective, study involving 44 institutions in Japan including 1006 patients KD, was examined. were classified by z score their internal diameter acute phase: small (z<5), medium (5≤z<10), large (z≥10). lower...
Blood flow visualization using vector mapping (VFM) holds potential as a novel indicator of right ventricular (RV) function. This study included 12 patients with atrial septal defect (ASD group, mean (± standard deviation) age: 6.2 ± 1.5 years), six pulmonary hypertension (PH 6.8 2.3 and 35 healthy, age-matched children (control 7.3 1.6 years). VFM data were obtained from the parasternal RV short-axis view. images in majority control group showed counterclockwise rotating vortex below...
Genetic testing for long QT syndrome (LQTS) is useful diagnosis, risk stratification, and therapeutic strategies. This study investigated the clinical impact of genetic LQTS patients. Total 3,851 patients (proband: 2,316 [60%]; female: 2,283 [59%]; median age: 14 years [interquartile range 9-36 years]) diagnosed with (LQTS score ≥3.5, QTc ≥500 ms, pathogenic variants in LQTS-associated genes, or unexplored syncope 480-499 ms) were enrolled this study. Of these patients, 1,146 (29.8%)...
Objective: In patients with Duchenne's progressive muscular dystrophy (DMD), myocardial fibrosis begins from the epicardial half of left ventricular posterior wall. Myocardial strain imaging by tissue Doppler echocardiography is a new method for assessing regional function. We hypothesized that this might be useful early detection subclinical involvement in DMD patients. Methods: radial ventricle was measured 25 (age: 14.8 ± 3.1 years) normal shortening fraction and age‐matched healthy...
The vasoconstrictor angiotensin II (ANG II) inhibits several types of K + channels. We examined the inhibitory mechanism ANG on voltage-gated (K V ) currents ( I recorded from isolated rat arterial smooth muscle using patch-clamp techniques. Application 100 nM accelerated activation but also caused inactivation. These effects were abolished by AT 1 receptor antagonist losartan. protein kinase A (PKA) inhibitor Rp-cyclic 3′,5′-hydrogen phosphothioate adenosine (100 μM) and an analog...
Although endothelium-derived hyperpolarizing factor (EDHF) activity has been demonstrated in arteries from various species, EDHF not chemically identified, nor its mechanism of action characterized. To elucidate this mechanism, we tested the effect on large-conductance Ca2+-activated K+ (KCa) channels porcine coronary artery smooth muscle cells. By using a patch-clamp technique, single-channel currents were recorded cultured cells; organ bath also contained strip with endothelium, which...
The purpose of this study was to assess the feasibility morphological and functional evaluation helical ventricular myocardial band using standard echocardiographic images.Echocardiographic data were obtained from 132 normal children. We attempted identify echogenic bright line serving as boundary between ascending descending segments in septum, left inferior wall model proposed by Torrent-Guasp. Myocardial deformations on both sides compared speckle tracking echocardiography.The separating...
Objective. We studied the time course of hepatic dysfunction, seropositivity to hepatitis C virus (HCV) antibodies, viremia, and histologic evidence injury evaluate HCV infection in children infected by blood transfusion. Patients methods. Twenty-nine patients (ages 4 18 years) who underwent open-heart surgeries for congenital heart disease were grouped into three categories based on alterations serum alanine aminotransferase (ALT) levels: Group A, acute infection; B, subacute C, chronic...
Assessing autonomic function is important for patients with chronic heart failure, but the way that changes in Duchenne muscular dystrophy (DMD) and correlates other clinical parameters during their young age not clearly known.Heart rate variability (HRV) ambulatory electrocardiogram (ECG) was performed 57 DMD (130 recordings) who were receiving medication (mean 15.3 +/- 4.5 years). The data compared serum levels of brain natriuretic peptide (BNP), shortening fraction (SF) left ventricle on...
Although chromosome 1p36 deletion syndrome is considered clinically recognizable based on characteristic features, the clinical manifestations of patients during infancy are often not consistent with those observed later in life. We report a 4-month-old girl who showed multiple congenital anomalies and developmental delay, but no signs syndromic disease caused by terminal 1p36.32-p36.33 that was first identified targeted-exome sequencing for molecular diagnosis.
1. We have investigated the possible role of A-kinase anchoring proteins (AKAPs) in protein kinase A (PKA) signalling to ATP-sensitive K+ (K(ATP)) channels rat isolated mesenteric arterial smooth muscle cells using whole-cell patch clamp and peptides that inhibit PKA-AKAP binding. 2. Intracellular Ht31 peptide (20 microM), which inhibits interaction, blocked K(ATP) current activation by either dibutyryl cAMP or calcitonin gene-related peptide. Ht31-proline does not PKA binding AKAP, did...