A5001853247- Cardiac Arrhythmias and Treatments
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Issues in Pregnancy
- Ion channel regulation and function
- Mechanical Circulatory Support Devices
- Coronary Artery Anomalies
- Pulmonary Hypertension Research and Treatments
- Congenital heart defects research
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Kawasaki Disease and Coronary Complications
- Infective Endocarditis Diagnosis and Management
- Heart Failure Treatment and Management
- Food Allergy and Anaphylaxis Research
- Transplantation: Methods and Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Asthma and respiratory diseases
- Receptor Mechanisms and Signaling
- Immunodeficiency and Autoimmune Disorders
National Cerebral and Cardiovascular Center
2016-2025
Kao Corporation (Japan)
2016
Keio University
1953-2014
Tokyo Women's Medical University
2014
Fukuoka Children's Hospital and Medical Center for Infectious Diseases
2014
National Center For Child Health and Development
2014
Gifu Prefectural General Medical Center
2010
Gifu University
1996-2008
The prognostic value of cardiopulmonary exercise testing (CPX) for mortality risk remains controversial in Fontan patients.Our goal the present study was to clarify major CPX variables and factors determining capacity a large cohort patients.Since 1990, heart rate (HR), oxygen uptake (VO2 ), ventilatory equivalent carbon dioxide production (VE/VCO2 ) at peak were determined 335 patients (18 ± 5 years old), compared with clinical profile events.When 209 controls, HR (148 24 bpm), VO2 (27 7...
Determinant risk factors for developing protein losing enteropathy (PLE), including haemodynamics, remain unclear in patients after the Fontan operation.Our purpose was to characterize serial PLE haemodynamics before and onset determine based on cardiac catheterization-based analysis.Of 354 survivors who had undergone postoperative catheterizations, we experienced 26 during follow-up. Non-left ventricular morphology systemic ventricle, functional one-lung pulmonary circulation an early high...
<h3>Background</h3> Pregnancy is one of the biggest concerns for women with long QT syndrome (LQTS). <h3>Objectives</h3> This study investigated pregnancy-related arrhythmic risk and efficacy safety β-blocker therapy lethal ventricular arrhythmias in pregnant LQTS (LQT-P) their babies. <h3>Methods</h3> 136 pregnancies 76 LQT-P (29±5 years old; 22 LQT1, 36 LQT2, LQT3, 17 genotype-unknown) were enrolled. We retrospectively analysed clinical electrophysiological characteristics pregnancy...
Genetic testing for long QT syndrome (LQTS) is useful diagnosis, risk stratification, and therapeutic strategies. This study investigated the clinical impact of genetic LQTS patients. Total 3,851 patients (proband: 2,316 [60%]; female: 2,283 [59%]; median age: 14 years [interquartile range 9-36 years]) diagnosed with (LQTS score ≥3.5, QTc ≥500 ms, pathogenic variants in LQTS-associated genes, or unexplored syncope 480-499 ms) were enrolled this study. Of these patients, 1,146 (29.8%)...
The long-term prognosis of cardiac ryanodine receptor (RyR2) positive catecholaminergic polymorphic ventricular tachycardia (CPVT) patients after initiation medical therapy has not been well investigated. This study aimed to assess the recurrence fatal event inRyR2-positive CPVT patients.Thirty-fourRyR2-positive with a history events were enrolled. All had treatment initiated first symptom or diagnosis. Exercise stress tests (ESTs) performed evaluate efficacy therapy. Even therapy, high-risk...
Background: The serial hemodynamics and predictors of long-term, good Fontan survivors remain unknown. Methods Results: Two hundred one patients who had undergone a operation before September 1998 were reviewed to compare their long-term clinical status with hemodynamics. During mean follow-up 18.7 years, 47 (30.1%) the 156 no events that required an unscheduled hospitalization. Of those, 18 exhibited respective values central venous pressure (CVP, mmHg), cardiac index (CI, L·min-1·m2),...
This study aims to assess the impact of pacing sites on effectiveness cardiac resynchronization therapy (CRT) in systemic right ventricle (sRV) patients with/without a rudimentary left (rLV). We evaluated 13 procedures 11 sRV with wide QRS (>150 ms). Based digitalization results ventriculography, long-axis dyssynchrony (LD) was defined as extremely delayed ventricular (RV) outflow tract movement: ≥100 ms delay from RV apical contraction, and short-axis (SD) paradoxical contraction between...
Background:Cardiac resynchronization therapy (CRT) can result in functional improvement and reduced mortality patients with medically refractory heart failure. Although CRT is reportedly effective congenital disease (CHD), it still controversial who have systemic right ventricle.Methods Results:Twenty CHD treated since 2006 were divided into 3 groups based on ventricular (sysV) morphology (7 left ventricle [sLV], 7 [sRV], 6 unbalanced 2 ventricles as a single-ventricular physiology [sBV])....
Human cardiac ryanodine receptor 2 (RYR2) shows autosomal-dominant inheritance in catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1); however, de novo variants have been observed sporadic cases. Here, we investigated CPVT1-related RYR2 variant and its clinical significance between familial We enrolled 82 independent CPVT1 probands (median age: 10.0 (7.0-13.0) years; 45 male) carrying the whose biological origin could be confirmed by parental genetic analysis: assured...
Over a 25-year period, we encountered 12 patients who died suddenly with coronary arterial lesions due to Kawasaki disease. We report their clinical course, and analyze the happenings of deaths. Of patients, 10 were dead on arrival at hospital. Their age death ranged from 13 months 27 years, median 16 interval onset disease 2 24 years. In 4 was found be myocardial infarction, while in remaining 8, it could not determined. 7 angiograms obtained less than after acute showed bilaterally, most...
<h3>Importance</h3> Long QT syndrome (LQTS) is caused by several ion channel genes, yet risk of arrhythmic events not determined solely the responsible gene pathogenic variants. Female sex after adolescence associated with a higher in individuals congenital LQTS, but association between and genotype-based LQTS still unclear. <h3>Objective</h3> To examine location LQTS-related variant as it pertains to life-threatening arrhythmias. <h3>Design, Setting, Participants</h3> This retrospective...
Background Cow's milk allergy impairs the health and development of many infants since it deprives them adequate nutrition. fractions contain allergens, β‐lactoglobulin (BLG) is one major allergens. Objective The purpose this study was to determine T cell epitopes, antigen‐presenting molecules cytokine production by cells in relation BLG. results can provide new therapeutic possibilities using analogue peptides BLG for with cow's allergy. Methods Using a mixture panel overlapping synthetic...
Recently, infant cases of acute heart failure attributable to rupture the mitral chordae tendineae have been reported. However, little is known about pathogenesis and clinical course this condition.Ninety-five children with were identified in nationwide surveys Japan diagnosed from 1995 2013. The manifestations, management strategies, prognosis investigated. Eighty-one (85%) patients between 4 6 months (median, 5 months) age. In 63 (66%) patients, occurred during spring or summer. underlying...
Supraventricular and ventricular tachyarrhythmias (SVT, VT) are major concerns after repair of tetralogy Fallot (TOF). This study evaluated the impact comprehensive treatment, including hemodynamic interventions such as surgery, catheter-based intervention pacemaker implantation (PMI), on tachyarrhythmia in repaired TOF patients.Of 66 patients with (age at onset, 23±11 years), 29 had sustained SVT, 21 or non-sustained VT, 16 both (SVT+VT). Successful treatment catheter-directed ablation...
Introduction Several retrospective or single-centre studies demonstrated the efficacy of transplacental treatment fetal tachyarrhythmias. Our nationwide survey showed that therapy will be successful at an overall rate 90%. For fetuses with hydrops, success 80%. However, standard protocol has not been established. The objective this study is to evaluate and safety protocol-defined Participant recruitment began in October 2010. Methods analysis current a multicentre, single-arm interventional...