A5022769355- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Congenital Heart Disease Studies
- Congenital heart defects research
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Kawasaki Disease and Coronary Complications
- Cardiac electrophysiology and arrhythmias
- Mechanical Circulatory Support Devices
- Neuroscience and Neuropharmacology Research
- Ion Channels and Receptors
- Pulmonary Hypertension Research and Treatments
- Neuroscience and Neural Engineering
- Cardiovascular Effects of Exercise
- Heart Rate Variability and Autonomic Control
- Neurogenetic and Muscular Disorders Research
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Muscle Physiology and Disorders
- Cardiovascular and Diving-Related Complications
- Cystic Fibrosis Research Advances
- Pneumonia and Respiratory Infections
- Gastrointestinal motility and disorders
- Cardiovascular Issues in Pregnancy
Kurashiki Central Hospital
2011-2024
Okayama University Hospital
2024
Kurashiki Medical Center
2024
Fujita Health University
1998-1999
<h3>Background</h3> Pregnancy is one of the biggest concerns for women with long QT syndrome (LQTS). <h3>Objectives</h3> This study investigated pregnancy-related arrhythmic risk and efficacy safety β-blocker therapy lethal ventricular arrhythmias in pregnant LQTS (LQT-P) their babies. <h3>Methods</h3> 136 pregnancies 76 LQT-P (29±5 years old; 22 LQT1, 36 LQT2, LQT3, 17 genotype-unknown) were enrolled. We retrospectively analysed clinical electrophysiological characteristics pregnancy...
Effects of cibenzoline (0.1-30 microM) on membrane potentials and currents were investigated in rabbit sinoatrial node cells using conventional microelectrode double voltage clamp methods. Cibenzoline reduced the heart rate, maximum rate rise action potential amplitude a dose-dependent manner. At same time, duration at half-amplitude was prolonged, slope phase 4 depolarization decelerated. The experiment revealed that (7-30 depressed slow inward current, time-dependent potassium outward...
1 Thapsigargin (TPG, 3 μm) and cyclopiazonic acid (CPA, 10 slowly increased muscle tone in the guinea-pig isolated tracheal muscle. A large sustained contraction was produced when 2.4 mm Ca2+ readmitted after min exposure to Ca2+-free solution following 30 treatment with TPG or CPA. 2 The readmission partially inhibited by nifedipine (3 highly dependent on external Ca2+. TPG- CPA-induced contractions were 75% 67%, respectively, of carbachol (Cch, μm, EC80) presence nifedipine. Cch, CPA all...
1. Circular muscle strips of the guinea-pig gastric produced spontaneous electrical activity in form slow waves. The wave amplitude, maximum rate rise, duration, and frequency were 31 mV, 60 mV sec-1, 4.3 sec, min-1 on average, respectively. These parameters not appreciably affected by 3μM nifedipine or nicardipine, even following membrane depolarization with 60mM K+.2. Ni2+ (1-100μM) increased amplitude frequency, but reduced accompanied depolarization. rise slowly recovered to control...
Abstract Background Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. Some patients with DCM could manifest improvement in these abnormalities called left reverse remodeling (LVRR). However, the detailed association between genotypes clinical outcomes, including LVRR, particularly among pediatric patients, remains uncertain. Methods We prospectively enrolled from Japanese multi-institutional centers 2014...
Abstract Background: Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. However, some patients with DCM improve when experiencing left reverse remodeling (LVRR). Currently, the detailed association between genotypes clinical outcomes, including LVRR, particularly among children, remains uncertain. Methods: Pediatric from multiple Japanese institutions recorded 2014 2023 were enrolled. We identified their...
Background Left ventricular noncompaction (LVNC) is a hereditary type of cardiomyopathy characterized by prominent trabeculations. Detailed characteristics biventricular (BiVNC) remain unknown. This study aimed to elucidate the clinical and genetic landscape BiVNC. Methods Results We recruited children with left from Japanese multi‐institutional centers 2013 2021. was classified as BiVNC, congenital heart disease, arrhythmia, dilated cardiomyopathy, or normal function. In these patients,...
Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. However, some patients with DCM improve when experiencing left reverse remodeling (LVRR). Currently, the detailed association between genotypes clinical outcomes, including LVRR, particularly among children, remains uncertain. Pediatric from multiple Japanese institutions recorded 2014 2023 were enrolled. We identified their DCM-related genes explored gene...
Capillary refill time (CRT) is a valuable clinical sign in pediatric assessment, particularly evaluating circulatory status. We present case of one-month-old infant with supraventricular tachycardia (SVT), who demonstrated prolonged CRT, emphasizing the importance this physical examination finding context other signs compromised circulation.
Fontan術後の蛋白漏出性胃腸症（PLE）に対しトルバプタンを使用してPLEが改善した2症例を報告する．症例1は無脾症候群，右胸心，共通房室弁口，単心室，肺動脈閉鎖，総肺動脈還流異常症（TAPVC）のFontan術後の8歳男児．アルブミン補充，ステロイド投与にもかかわらずAlb2g/dL台，TP 3g/dL台と低値だったが，トルバプタン投与後より正常範囲内となりステロイドを漸減できた．またPLEによる下痢も改善し普通便となった．症例2は多脾症候群，単心室，共通房室弁口，両大血管右室起始，肺動脈閉鎖，下大静脈欠損（奇静脈交通）に対するFontan術後の19歳男性．トルバプタン投与前はAlb 2.0g/dL，TP 4.0g/dLだったがトルバプタン投与により正常範囲内に回復し，腹水も軽減した．トルバプタンがFontan術後PLEに対する内科的治療の一選択肢となりうる可能性が示唆された．
Abstract Background Hypoplastic coronary artery disease (HCAD) is an extremely rare associated with a risk of sudden cardiac death. It rarely recognized in live paediatric patient. Case summary We report case HCAD patient who first presented vomiting and poor feeding, suggestive acute heart failure due to cardiomyopathy or myocarditis infancy. Hypertension signs ischaemia became evident on electrocardiography scintigraphy after his function fully recovered, he was diagnosed by angiography...
In the circular muscle of guinea-pig gastric antrum, contribution glycolysis to spontaneous electrical activity, slow wave, was studied. The wave could be maintained without a marked change in glucose-free solution for more than 1 h even when treated with iodoacetic acid (IAA, 0.1–0.5 mm). However, reapplication glucose following IAA treatment produced clear inhibitory effects on wave. Lactate release from tissue reduced about 10% control by (0.1 mm) absence and there very recovery...
1. In smooth muscles isolated from the guinea-pig trachea, effects of dihydropyridines, nifedipine and nicardipine on contractions produced by carbachol (Cch) were studied in normal (6 mM) excess K+ concentration (60 mM). The tonic contraction 1 microM Cch was highly dependent external Ca2+ ([Ca2+]0) not significantly affected cyclopiazonic acid or thapsigargin, uptake inhibitor. 2. [Ca2+]0-tension curves steeper presence (the Hill coefficient: 2.5) than 60 mM (Hill 1.6) their ED50 0.16 0.39...
Introduction: The standard dose of intravenous immunoglobulin (IVIG) as initial therapy for patients with Kawasaki disease (KD) is generally 2 g/kg. In our hospital, the IVIG KD 1 g/kg, which augmented according to treatment response, and changed plasma exchange (PE) if over 6 g/kg ineffective. To date, various factors scoring systems predicting resistance have been reported. We evaluated consecutive urinary β2 microglobulin creatinine ratio (β2MG/Cr) data a possible predictive factor...
Pulmonary arteriovenous malformations (PAVMs) are abnormal communications between the pulmonary arteries and veins; right-to-left shunts can cause hypoxaemia, emboli to systemic circulation, brain abscesses. Cyanosis during pregnancy may increase probability of premature birth or spontaneous abortion maternal cardiac complications.We describe a case 24-year-old woman with diffuse multiple PAVMs localized left inferior lobe chronic cyanosis. She had increased exertional fatigue headaches was...
Therapeutic plasma exchange (TPE) is used for treating refractory Kawasaki disease (KD); however, there are few reports on its use in small children.