A5026571448- Cardiomyopathy and Myosin Studies
- Congenital heart defects research
- Cardiovascular Function and Risk Factors
- Neurogenetic and Muscular Disorders Research
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- Kawasaki Disease and Coronary Complications
- Cardiac Structural Anomalies and Repair
- Viral Infections and Immunology Research
- Cardiac pacing and defibrillation studies
- Genomics and Rare Diseases
- Coronary Artery Anomalies
- Blood Coagulation and Thrombosis Mechanisms
- Force Microscopy Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Issues in Pregnancy
- Williams Syndrome Research
- Whipple's Disease and Interleukins
- Cardiac Imaging and Diagnostics
- Angiogenesis and VEGF in Cancer
- Pericarditis and Cardiac Tamponade
- Muscle Physiology and Disorders
- Heart Failure Treatment and Management
- Lipid metabolism and disorders
- Coronary Interventions and Diagnostics
University of Toyama
2018-2024
Toyama University Hospital
2019-2024
Takara (Japan)
2020
Left ventricular noncompaction (LVNC) is a hereditary cardiomyopathy that associated with high morbidity and mortality rates. Recently, LVNC was classified into several phenotypes including congenital heart disease (CHD). However, although CHD are frequently observed, the role clinical significance of genetics in these cardiomyopathies has not been fully evaluated. Therefore, we aimed to evaluate impact on perioperative outcomes children concomitant using next-generation sequencing...
Background: Tachycardia-induced cardiomyopathy (TIC) is caused by prolonged tachycardia leading to left ventricular dilatation and systolic dysfunction with heart failure. Although TIC more common in adult, it rare early infant. Methods: Clinical testing was performed as part of medical evaluation management. Next gene se-quencing (NGS) for a patient TIC. Literature review about con-ducted. Results: The case 5-month-old infant referred the hospital due symptoms failure at least lasting two...
Left ventricular noncompaction (LVNC) is a hereditary type of cardiomyopathy. Although it associated with high morbidity and mortality, the related ion channel gene variants in children have not been fully investigated. This study aimed to elucidate genetic landscape LVNC identify genotype-phenotype correlations large Japanese cohort.We enrolled 206 from 2002 2017 Japan. was classified as follows: congenital heart defects, arrhythmia, dilated phenotype, or normal function. In patients, 182...
Left ventricular non-compaction (LVNC) is a cardiomyopathy morphologically characterized by 2-layered myocardium and numerous prominent trabeculations, often associated with dilated (DCM). Variants in the gene encoding tafazzin (TAZ) may change mitochondrial function cause dysfunction of many organs, but they also contribute to DCM phenotype LVNC, clinical echocardiographic features children this are poorly understood.
Background: Left ventricular hypertrophy (LVH) is a well-recognized cardiac dysfunction in infants of mothers with gestational diabetes mellitus (GDM). noncompaction (LVNC) cardiomyopathy that morphologically characterized by numerous prominent trabeculations and deep intertrabecular recesses on cardiovascular imaging. However, there have been no case reports neonates GDM showing LVH LVNC. Case presentation: A patient, mother GDM, was delivered at 36 weeks gestation. Prominent the LV,...
TBX5 is a transcription factor that has an important role in development of heart. variants the region encoding T-box domain have been shown to cause cardiac defects, such as atrial septal defect or ventricular defect, while also identified few cardiomyopathy patients and considered causative. We variant (c.791G>A, p.Arg264Lys), over-represented patients. This located outside domain, its pathogenicity not confirmed by functional analyses.To investigate whether R264K deleterious could...
Left ventricular noncompaction (LVNC) is morphologically characterized by numerous prominent trabeculations and a severely thickened, two-layered myocardium. The fetal onset of LVNC has rarely been described.Methods Results:We conducted nationwide retrospective surveys on cardiomyopathy (CM) in Japan from 2010 to 2016, which 38 patients with CM were enrolled, including 16 LVNC. rate diagnostic concordance was 56.3% between postnatal visits patients. increase the ratio noncompacted compacted...
Background Left ventricular noncompaction (LVNC) is a hereditary type of cardiomyopathy characterized by prominent trabeculations. Detailed characteristics biventricular (BiVNC) remain unknown. This study aimed to elucidate the clinical and genetic landscape BiVNC. Methods Results We recruited children with left from Japanese multi‐institutional centers 2013 2021. was classified as BiVNC, congenital heart disease, arrhythmia, dilated cardiomyopathy, or normal function. In these patients,...
Abstract Background Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. Some patients with DCM could manifest improvement in these abnormalities called left reverse remodeling (LVRR). However, the detailed association between genotypes clinical outcomes, including LVRR, particularly among pediatric patients, remains uncertain. Methods We prospectively enrolled from Japanese multi-institutional centers 2014...
Abstract Background: Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. However, some patients with DCM improve when experiencing left reverse remodeling (LVRR). Currently, the detailed association between genotypes clinical outcomes, including LVRR, particularly among children, remains uncertain. Methods: Pediatric from multiple Japanese institutions recorded 2014 2023 were enrolled. We identified their...
Background: Tachycardia-induced cardiomyopathy (TIC) is caused by prolonged tachycardia, leading to left ventricular dilatation and systolic dysfunction with heart failure. Although TIC more common in adults, it rare early infancy. Methods: Clinical testing was performed as part of medical evaluation management. Next-generation sequencing (NGS) conducted for a patient TIC. A literature review on also conducted. Results: The case involved 5-month-old infant referred the hospital due symptoms...
Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. However, some patients with DCM improve when experiencing left reverse remodeling (LVRR). Currently, the detailed association between genotypes clinical outcomes, including LVRR, particularly among children, remains uncertain. Pediatric from multiple Japanese institutions recorded 2014 2023 were enrolled. We identified their DCM-related genes explored gene...
Abstract Background Left ventricular noncompaction cardiomyopathy (LVNC) is characterized by prominent trabeculations on cardiovascular imaging. Acquired reversible LVNC has not been reported in pediatrics without a genetic background. Case presentation A 9-year-old girl with ventriculoperitoneal (VP) shunt for neonatal posthemorrhagic hydrocephalus was referred due to exacerbation of caused VP dysfunction. Transthoracic echocardiography (TTE) revealed depressed left (LV) systolic function...
【背景】心筋緻密化障害は未だ臨床像，管理方法，予後など不明な点が多い．
(1) Background: The optimal heart rate, at which the E-wave and A-wave stand adjacent without any overlaps in Doppler transmitral flow echocardiography, is associated with maximum cardiac output favorable clinical outcomes adult patients systolic failure. However, implication of echocardiographic overlap length Fontan circulation remains unknown. We investigated relationship between rate (HR) hemodynamics surgery beta-blockers. (2) Methods Results: A total 26 (median age 1.8 years, 13 males)...
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