A5102834189- Hydrogen's biological and therapeutic effects
- Lung Cancer Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Myasthenia Gravis and Thymoma
- Anesthesia and Neurotoxicity Research
- Cancer Cells and Metastasis
- Organ Transplantation Techniques and Outcomes
- Cardiac tumors and thrombi
- Lung Cancer Treatments and Mutations
- Cardiac Ischemia and Reperfusion
- Cancer, Hypoxia, and Metabolism
- Peripheral Neuropathies and Disorders
- Cardiac Arrest and Resuscitation
- Thin-Film Transistor Technologies
- Silicon Nanostructures and Photoluminescence
- Silicon and Solar Cell Technologies
- Tracheal and airway disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Metastasis and carcinoma case studies
- Chronic Kidney Disease and Diabetes
- Effects of Vibration on Health
- Visual perception and processing mechanisms
- Respiratory Support and Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
Nobuhara Hospital
2017-2025
Osaka City General Hospital
2020-2023
Osaka Prefectural Medical Center
2020-2023
Ashiya University
2023
University College London
2023
Chiba University
2022
Saitama Medical University Hospital
2020
Osaka University
2010-2019
Nagoya Institute of Technology
2016-2018
Iwate University
2017-2018
Hyperoxic lung injury is a major concern in critically ill patients who receive high concentrations of oxygen to treat diseases. Successful abrogation hyperoxic would have huge impact on respiratory and critical care medicine. Hydrogen can be administered as therapeutic medical gas. We recently demonstrated that inhaled hydrogen reduced transplant-induced induced heme oxygenase (HO)-1. To determine whether could reduce investigate the underlying mechanisms, we randomly assigned rats four...
Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects are believed to be associated with increased oxidative stress inflammation due the generation reactive oxygen species during radiotherapy. Hydrogen can administered as a therapeutic medical gas, has antioxidant properties, reduces in tissues. This study examined whether hydrogen treatment, form hydrogen-supplemented water, improved QOL A randomized, placebo-controlled was...
Transplantation is published monthly and the most cited influential journal in field, with more than 25,000 citations per year. The celebrated its 50th year 2016. has been trusted source for extensive timely coverage of important advances transplantation. Editors Editorial Board are an international group research clinical leaders that includes many pioneers representing a diverse range areas expertise. This capable editorial team provides thoughtful thorough peer review, delivers rapid,...
Abstract Introduction Mechanical ventilation (MV) can provoke oxidative stress and an inflammatory response, subsequently cause ventilator-induced lung injury (VILI), a major of mortality morbidity patients in the intensive care unit. Inhaled hydrogen act as antioxidant may be useful novel therapeutic gas. We hypothesized that, owing to its anti-inflammatory properties, inhaled therapy could ameliorate VILI. Methods VILI was generated male C57BL6 mice by performing tracheostomy placing on...
Salt-inducible kinase 3 (SIK3), an AMP-activated protein kinase-related kinase, is induced in the murine liver after consumption of a diet rich fat, sucrose, and cholesterol. To examine whether SIK3 can modulate glucose lipid metabolism liver, we analyzed phenotypes SIK3-deficent mice. Sik3−/− mice have malnourished phenotype (i.e., lipodystrophy, hypolipidemia, hypoglycemia, hyper-insulin sensitivity) accompanied by cholestasis cholelithiasis. The hypoglycemic hyper-insulin-sensitive may be...
Background. Inhaled hydrogen gas exerts antioxidant and anti-inflammatory effects in rat intestinal transplantation. Here, we investigated whether ex vivo donor organ treatment with dissolved would prevent graft injury. Methods. Isogeneic transplantation was performed Lewis rats vascular flush, luminal preservation, cold storage nitrogen-bubbled (SITxN2) or hydrogen-bubbled (SITxH2) preservation solution. Lactated Ringer's solution 3-hr ischemia time were used for mechanistic investigations,...
AimsArterialized vein grafts often fail due to intimal hyperplasia. Hydrogen potently protects organs and cells from many insults via its anti-inflammatory antioxidant properties. We investigated the efficacy of oral administration hydrogen-rich water (HW) for prevention
Alterations to the tumor stromal microenvironment induced by chemotherapy could influence behavior of cancer cells. In microenvironment, cancer-associated fibroblasts (CAFs) play an important role. Because receptor tyrosine kinase Axl and its ligand Gas6 be involved in promoting non-small cell lung (NSCLC), we investigated role secreted CAFs during NSCLC. a murine model, found that expression was upregulated following cisplatin treatment. might influenced intratumoral hypoperfusion...
A 60-year-old male patient with metastasis from sigmoid colon cancer in the pancreatic uncinate process who received chemotherapy was treated edoxaban (EDO) because of deep vein thrombosis. The appeared to shrink, but had repeated acute pancreatitis. An upper gastrointestinal endoscopy performed determine cause. Bleeding major papilla and minor detected, he diagnosed hemosuccus pancreaticus. Pancreatic duct stenting conducted papilla. pancreatitis then improved EDO dosage reduced. stent fell...
Background Lung transplantation has been established as the definitive treatment option for patients with advanced lymphangioleiomyomatosis (LAM). However, prognosis after registration and circumstances of lung sirolimus therapy have never reported. Methods In this national survey, we analyzed data from 98 LAM registered in Japan Organ Transplantation Network. Results was performed 57 March 2014. Survival rate 86.7% at 1 year, 82.5% 3 years, 73.7% 5 10 years. Of patients, 21 had an inactive...
Size-dependent homogeneous linewidth of Z3 exciton absorption spectra in CuCl microcrystals was measured at 2 K by the pump-and-probe spectroscopy. Observation hole burning gave us linewidth. The size-dependent part is inversely proportional to square radius microcrystals. This dependence explained a simple model that generated dephases through scattering irregular surface
Epithelial–mesenchymal transition ( EMT ) plays an important role in the progression of lung carcinoma. Podocalyxin PODXL ), which belongs to CD 34 family and regulates cell morphology, has been linked cancer, overexpression is associated with poor prognosis several different classes cancers. The aim this study was clarify determine prognostic value tumors from cancer patients. marker expression, migration invasion abilities engineered A549 ‐knockdown KD or ‐overexpression OE adenocarcinoma...