A5026272910- Lung Cancer Treatments and Mutations
- Antifungal resistance and susceptibility
- Sarcoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Fungal Infections and Studies
- Occupational and environmental lung diseases
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Cancer Research and Treatments
- Infectious Diseases and Mycology
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Myasthenia Gravis and Thymoma
- Meningioma and schwannoma management
- Gastrointestinal Tumor Research and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Plant Pathogens and Fungal Diseases
- Radiomics and Machine Learning in Medical Imaging
Toho University
2016-2025
Toho University Omori Medical Center
2013-2025
National Cancer Centre Japan
2023
Asahi General Hospital
2012-2015
National Cancer Center Hospital East
2015
University of Pittsburgh Medical Center
2010-2013
National Cancer Center
2006-2013
Houston Methodist
2013
Methodist Hospital
2013
The University of Texas Health Science Center at Tyler
2013
Purpose The image noise and quality of a prototype ultra-high-resolution computed tomography (U-HRCT) scanner was evaluated compared with those conventional high-resolution CT (C-HRCT) scanners. Materials Methods This study approved by the institutional review board. A U-HRCT 0.25 mm x 4 rows operating at 120 mAs used. C-HRCT images were obtained using 0.5 16 or 64 detector-row 150 mAs. Images from both scanners reconstructed 0.1-mm intervals; slice thickness for For scanners, display field...
Abstract Pulmonary metastasis is the most significant prognostic determinant for osteosarcoma, but methods its prediction and treatment have not been established. Using oligonucleotide microarrays, we compared global gene expression of biopsy samples between seven osteosarcoma patients who developed pulmonary within 4 years after neoadjuvant chemotherapy curative resection, 12 did relapse. We identified argininosuccinate synthetase (ASS) as a differentially expressed with highest statistical...
Abstract Introduction Mechanical ventilation (MV) can provoke oxidative stress and an inflammatory response, subsequently cause ventilator-induced lung injury (VILI), a major of mortality morbidity patients in the intensive care unit. Inhaled hydrogen act as antioxidant may be useful novel therapeutic gas. We hypothesized that, owing to its anti-inflammatory properties, inhaled therapy could ameliorate VILI. Methods VILI was generated male C57BL6 mice by performing tracheostomy placing on...
Molecular testing of pulmonary adenocarcinomas for EGFR and KRAS mutations is becoming more common as tyrosine kinase inhibitor therapy used EGFR-mutated adenocarcinomas. Adenosquamous carcinomas represent a hybrid carcinoma, there no literature addressing the frequency in this subset lung Western populations. For study, 23 adenosquamous were microdissected with glandular squamous components analyzed amplification. In 3 cases (13%), mutations, 2 having identical mutation elements. both...
Histologic subtyping of non-small cell lung carcinoma (NSCLC) is important because the efficacy new treatments depends on tumor histologic features. We assessed diagnostic accuracy classification adenocarcinoma and squamous (SCC) cytologic biopsy specimens based cytomorphologic studies alone or in combination with ancillary compared resection specimens. Compared adenocarcinoma, diagnosis SCC was more often (139/185 [75.1%] vs 107/263 [40.7%]). Significantly increased use immunohistochemical...
Adipokines are bioactive hormones secreted by adipose tissues. Resistin, an adipokine, plays important roles in the regulation of insulin resistance and inflammation. Resistin levels known to be increased serum synovial fluid rheumatoid arthritis (RA) patients. However, pathogenic role resistin RA has not yet been elucidated.The expression adenylate cyclase-associated protein 1 (CAP1), a receptor for resistin, was examined immunohistochemically tissue. CAP1 vitro cultured fibroblast-like...
We aimed to identify novel prognostic biomarkers for Ewing's sarcoma by investigating the global protein expression profile of patients.We examined proteomic eight biopsy samples from patients using two-dimensional difference gel electrophoresis. Three were alive and continuously disease-free over 3 years after initial diagnosis (good prognosis group) five had died disease within 2 (poor group).The profiles produced electrophoresis consisted 2,364 spots, among which we identified 66 spots...
Whole transcriptome analyses have revealed a large number of novel transcripts including long and short noncoding RNAs (ncRNAs). Currently, there is great interest in characterizing the functions different classes ncRNAs their relevance to cellular processes. In particular, nuclear may be involved controlling various aspects biological regulation, such as stress responses. By combination bioinformatic experimental approaches, we identified 25 from 6,088,565 full-length human cDNA sequences....
Gangliocytic paraganglioma (GP) is an extremely rare benign tumor that commonly arises from the second part of duodenum. Since GP exhibit neither prominent mitotic activity nor Ki-67 immunoreactivity, this often misdiagnosed as neuroendocrine (NET) G1 (carcinoid tumor). However, patients with may have a better prognosis than NET G1. This fact emphasizes importance differentiating G1, but few studies reported epidemiology and histopathology because its rarity. To differentiate ease, we...
Stent-induced ductal change is a complication of endoscopic treatment the main pancreatic duct in chronic pancreatitis. Most previous reports have been based on morphological changes observed via pancreatography. Here, we describe case stent-induced which course mucosal was through peroral pancreatoscopy with videoscopy. The patient presented alcoholic Main stenosis head identified and 10-Fr plastic stent inserted. Follow-up pancreatography revealed focally elevated approximately 4.5 mm at...
Abstract Context.—The lung is the most common site of metastasis during natural history malignant tumors. Breast carcinoma has a propensity for distant metastasis, and pleura are among metastatic sites. Although it often difficult to make clear-cut differential diagnosis between two, distinguishing primary from breast important because treatment modalities different. Objective.—To elucidate utility mammaglobin gross cystic disease fluid protein 15 (GCDFP-15), which known be breast-specific...
Context.—The diagnosis of sarcomatoid neoplasms the lung and pleura can be challenging. Homozygous deletion 9p21, locus harboring p16 gene, has been reported as most common genetic alteration in malignant mesotheliomas that is potential diagnostic prognostic significance.Objectives.—To evaluate frequency 9p21 by fluorescence situ hybridization primary to determine its utility.Design.—Ninety-two (32 mesotheliomas, 15 carcinomas, 32 solitary fibrous tumors, 13 high-grade sarcomas) were...
Long non‑coding RNAs (lncRNAs) have been reported to be involved in the physiological and pathological processes of tumor pathogenesis, including epithelial‑mesenchymal transition (EMT). However, epidermal growth factor receptor (EGFR)‑tyrosine kinase inhibitor (TKI) resistance is a major challenge treatment advanced recurrent EGFR‑mutant lung adenocarcinoma. An increased understanding underlying mechanisms would aid development effective therapeutic strategies against EGFR‑TKI resistance,...
Hepatoid carcinoma of the ovary is an ovarian that has phenotypic properties in common with hepatocellular carcinomas. However, extent tumor cells' similarity to and their difference from hepatocytes largely unknown. In addition, precursor cell origin for hepatoid not been identified. Three cases alpha-fetoprotein-producing were admixed adenocarcinoma surface epithelial type are reported. The carcinomas had a trabecular architecture canaliculi detected by polyclonal (but monoclonal)...
We aimed to identify novel chemotherapy responsiveness biomarkers for osteosarcoma (OS) by investigating the global protein expression profile of 12 biopsy samples from OS patients.Six patients were classified as good responders and six poor responders, according Huvos grading system. The profiles obtained 2-D DIGE consisted 2250 spots.Among them, we identified 55 spots whose intensity was significantly different (Bonferroni adjusted p-value<0.01) between two patient groups. Mass...
This study aims to investigate the usefulness of (18)F-FDG PET/CT for distinguishing between primary thyroid lymphoma (PTL) and chronic thyroiditis.We retrospectively reviewed data 196 patients with diffuse uptake gland enrolled who were diagnosed as having PTL or thyroiditis based on medical records, pathological findings, laboratory data. The comprised 10 (M/F = 4:6) 51 8:43). Images had been acquired a scanner at 100 minutes after intravenous injection (18)F-FDG.The group consisted 7...
Abstract Background Programmed death ligand 1 (PD‐L1) inhibitor has been approved as one of the standard therapies for various cancers. Some reports have shown that serum PD‐L1 level is associated with advanced tumor stages and poor prognosis; however, corresponding pathological information in esophageal cancer patients lacking. Therefore, we evaluated clinicopathological prognostic impact levels surgically treated cancer. Methods A total 150 who underwent radical resection were included...
The clinical course of gastrointestinal stromal tumor (GIST) spans a wide spectrum from curable disorder to highly malignant disease that leads metastasis and death. To develop prognostic modalities for GIST patients, we developed mouse monoclonal antibody against pfetin, the value which has been previously reported. reactivity pfetin was examined by western blotting immunohistochemistry. Western demonstrated specific pfetin. immunohistochemical study 5-year disease-free survival rate 93.2%...