A5042480948- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Salivary Gland Tumors Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Tracheal and airway disorders
- Mycobacterium research and diagnosis
- Lung Cancer Research Studies
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Soft tissue tumor case studies
- Tuberculosis Research and Epidemiology
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Nuclear physics research studies
- Myasthenia Gravis and Thymoma
- Cancer and Skin Lesions
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Quantum Chromodynamics and Particle Interactions
- Cholangiocarcinoma and Gallbladder Cancer Studies
Kobe University
2020-2025
Osaka University
1958-2023
Himeji Medical Center
2023
Osaka Prefectural Medical Center
2012-2022
Tohoku University
2019-2021
Massachusetts General Hospital
2018
Università Cattolica del Sacro Cuore
2018
Virginia Commonwealth University
2018
John Wiley & Sons (United States)
2018
Hudson Institute
2018
BACKGROUND Homozygous deletion of 9p21 detected by fluorescence in situ hybridization (FISH) and loss BRCA1‐associated protein 1 (BAP1) expression immunohistochemistry (IHC) are useful for the differentiation between malignant pleural mesothelioma (MPM) reactive mesothelial hyperplasia. The authors previously described that IHC product methylthioadenosine phosphorylase ( MTAP ) gene, which is localized chromosomal region, was correlated with status FISH MPM tissues. In current study,...
Differentiation of malignant pleural mesothelioma (MPM) from benign mesothelial proliferation remains problematic. Loss nuclear staining BRCA1‐associated protein 1 (BAP1; detected using immunohistochemistry (IHC)) and homozygous deletion (HD) p16 (detected fluorescence in situ hybridization (FISH)) are useful for differentiation MPM reactive hyperplasia (RMH), but the correlation between BAP1 expression loss HD has not been fully described. We performed IHC ‐specific FISH 40 20 RMH cases,...
Data of the statistical radius 〈 S2 〉1 / 2 and second virial coefficient A2 were obtained for sharp fractions polychloroprene (PCP) in methyl ethyl ketone (MEK), n-butyl acetate, carbon tetrachloride at 25°C trans-decalin temperatures ranging from 1° to 50°C. MEK 2°C found be theta solvents PCP. From these data two dimensionless quantities defined by αs2 = 〉 S2〉0and Ψ A2M1/2[4π3/2NA( M3 2]−1 calculated all combinations molecular weight M, solvent species, temperature, where 〉0 is value under...
A 67-year-old man who was on medication for hypertension and unstable angina pectoris developed mild left hemiparesis day X-1. He made an emergency call at 4 am X due to persistent symptoms. Brain magnetic resonance imaging performing following admission showed multiple acute cerebral infarcts, resulting in the initiation of treatment by continuous intravenous heparin started. One hour later, after initial heparinization, he generalized seizure stopped breathing echocardiography. Emergency...
BACKGROUND In malignant pleural mesothelioma (MPM), most patients first present with effusion; thus, cytologic analysis is the primary diagnostic approach. However, distinction between MPM and reactive mesothelial cells (RMCs) in effusions can be extremely difficult due to lack of both well‐established immunocytochemical markers definite cytological criteria for MPM. Moreover, existence RMCs from same patient makes differentiation even more challenging. Homozygous deletion 9p21 locus, site...
Measurements of [η] were made for seven fractions polychloroprene (PCP) in methyl ethyl ketone, n-butyl acetate, and carbon tetrachloride at 25°C three PCP trans-decalin a number temperatures ranging from 0.05° to 65°C. On log–log graph paper, the values αη3( = [η]/[η]θ) calculated these data formed composite curve when plotted against αs3( 〈S2〉3/2/〈S2〉03/2) obtained light-scattering experiments under same conditions. This is characterized by relatively marked upward curvature vicinity...
Background/Aim: This study aimed to compare the efficacies of cryobiopsy and forceps biopsy for peripheral lung cancer detection. Patients Methods: A retrospective review cases between December 2017 April 2019 was conducted. Forceps performed followed by using a guide sheath (GS). Diagnostic yields were compared biopsy. Results: total 53 lesions evaluated. The diagnostic 86.8% 81.1%, respectively. Univariate multivariate analyses indicated that with GS significantly associated increased...
Background/Aim: The present study aimed to prospectively examine the usefulness of interferon-gamma (IFN-γ) release (IGR) as a biomarker in non-small-cell lung cancer patients receiving immune checkpoint inhibitor treatment (ICI-Tx). Patients and Methods: IGR was measured using enzyme-linked immunosorbent assay at four time points: within 14 days before ICI-Tx (T1), 8±3 (T2), 22±7 (T3), 43±7 (T4) after ICI-Tx. Results: Twenty-nine were divided into three groups based on IFN-γ levels...
Differentiating malignant pleural mesothelioma (MPM) cells morphologically from reactive mesothelial hyperplasia is problematic. Homozygous deletion (HD) of p16 ( CDKN2A ), detected by FISH, a good marker malignancy and useful to differentiate between these cells. However, the correlation status effusion smears that underlying MPM tissues has not been investigated. We used ‐specific FISH investigate 20 cases which both cytologic histologic specimens were available. In five cases, included an...
The classification of lung carcinoma is based on small biopsies and/or cytology in 80% patients with non-small cell carcinoma. However, there no widely accepted system for respiratory cytology. Japan Lung Cancer Society (JLCS) and Japanese Clinical Cytology (JSCC) have proposed a new four-tiered reporting the following categories: (1) "negative malignancy," (2) "atypical cells," (3) "suspicious (4) "malignancy."The aim this work was to perform an interobserver reproducibility study confirm...
Abstract We report the first case of a pathological complete response for plasmacytoid urothelial carcinoma bladder. A 76‐year‐old man was diagnosed with (T4, N0, M0) by microscopically appearance specimen from transurethral resection. Immunohistochemical studies were positive epithelial markers and negative lymphoid markers. Two cycles systemic chemotherapy performed methotrexate, etoposide, vinblastine, cisplatin, followed radical cystectomy. The examination revealed no residual cancer...
Aims Peritoneal malignant mesothelioma (PMM) is an uncommon tumour, accounting for only 7–9% of all mesotheliomas in Japan. Differential diagnosis between PMM and primary peritoneal serous carcinoma (PPSC), a high-grade carcinoma, may be difficult, separating reactive mesothelial hyperplasia (RMH) from can even more challenging. Methods To help differentiate PPSC RMH, we used immunohistochemistry to examine mesothelial-associated markers (calretinin, AE1/AE3, CK5/6, CAM5.2, D2-40, WT-1,...
Cutaneous T-Cell lymphoma (CTCL) is a non-Hodgkin's of unknown pathogenesis. Mycosis fungoides (MF) clinically determined subset CTCL with intensive infiltration cells into the epidermis. To determine whether Epstein-Barr virus (EBV) associated these cells, we performed mRNA in situ hybridization 5 cases and 7 MF using an RNA probe transcribed from BamHI W fragment EBV genome. These transcripts were detected majority all examined. We also signals on epidermal squamous contiguous to strong...
Abstract The tyrosine kinase c-Src is upregulated in various human cancers, although the precise regulatory mechanism underlying this upregulation unclear. We previously reported that a transmembrane adaptor Csk-binding protein (Cbp; PAG1) plays an important role controlling cell transformation induced by activation of c-Src. To elucidate vivo Cbp, we examined function Cbp lung cancer lines and tissues. In study, found was markedly downregulated non–small (NSCLC) cells. ectopic expression...