A5043747326- Genetic Mapping and Diversity in Plants and Animals
- Plant Virus Research Studies
- GABA and Rice Research
- Agriculture, Soil, Plant Science
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ocean Acidification Effects and Responses
- Freshwater macroinvertebrate diversity and ecology
- Marine Bivalve and Aquaculture Studies
- Plant Stress Responses and Tolerance
- Retinal Development and Disorders
- Blood properties and coagulation
- Immune Response and Inflammation
- Fish biology, ecology, and behavior
- Environmental DNA in Biodiversity Studies
- Chromosomal and Genetic Variations
- Zebrafish Biomedical Research Applications
- Advanced Glycation End Products research
- CO2 Sequestration and Geologic Interactions
- Plant pathogens and resistance mechanisms
- HIV/AIDS oral health manifestations
- Immune cells in cancer
- Soil, Finite Element Methods
- Marine Invertebrate Physiology and Ecology
- Osteomyelitis and Bone Disorders Research
- Plant Molecular Biology Research
Waseda University
2025
Heidelberg University
2021-2024
Tokyo University of Agriculture and Technology
2023
Tokyo University of Pharmacy and Life Sciences
2023
Nagoya University
2013-2021
Okayama University
2018
Hokkaido University
2016
University of Tsukuba
2015
Shizuoka University
2004-2011
Showa University
1997
Inflammatory stimuli cause a state of emergency myelopoiesis leading to neutrophil-like monocyte expansion. However, their function, the committed precursors, or growth factors remain elusive. In this study we find that Ym1+Ly6Chi monocytes, an immunoregulatory entity arise from progenitors neutrophil 1 (proNeu1). Granulocyte-colony stimulating factor (G-CSF) favors production monocytes through previously unknown CD81+CX3CR1lo precursors. GFI1 promotes differentiation proNeu2 proNeu1 at cost...
Retinal organoids have become important models for studying development and disease, yet stochastic heterogeneity in the formation of cell types, tissues, phenotypes remains a major challenge. This limits our ability to precisely experimentally address early developmental trajectories towards these outcomes. Here, we utilize deep learning predict differentiation path resulting tissues retinal well before they visually discernible. Our approach effectively bypasses challenge organoid-related...
Hypoxic encephalopathy due to prolonged cardiopulmonary arrest is associated with poor neurological prognosis, often leading significant impairment in activities of daily living (ADL) and social reintegration. Rehabilitation for patients experiencing cardiac lasting over 15 minutes rarely successful. This case report describes a 29-year-old male patient hypoxic following 19-minute while sauna, who achieved substantial ADL recovery through intensive acute-phase rehabilitation. Cardiopulmonary...
ABSTRACT High mobility group box 1 (HMGB1) is a non-histone DNA-binding protein that secreted into the extracellular milieu in response to inflammatory stimuli. The HMGB1 mediates various diseases, including periodontitis; however, underlying mechanisms of HMGB1-induced periodontal inflammation are not completely understood. Here, we examined whether anti-HMGB1 neutralizing antibody inhibits progression and investigated molecular pathology vitro vivo. In analysis indicated HMGB1,...
Unraveling the relationship between genetic variation and phenotypic traits remains a fundamental challenge in biology. Mapping variants underlying complex while controlling for confounding environmental factors is often problematic. To address this, we establish vertebrate resource specifically to allow robust genotype-to-phenotype investigations. The teleost medaka (Oryzias latipes) an established model system with long history of research high tolerance inbreeding from wild.
Abstract Plants adopt optimal tolerance strategies depending on the intensity and duration of stress. Retaining water is a priority under short-term drought conditions, whereas maintaining growth reproduction processes takes precedence over survival conditions prolonged drought. However, mechanism underlying changes in stress response degree unclear. Here, we report that SNF1-related protein kinase 2 (SnRK2) substrate 1 (SNS1) involved this regulation SNS1 phosphorylated stabilized by SnRK2...
Medaka fish (Oryzias latipes) is a powerful model to study genetics underlying the developmental and functional traits of vertebrate visual system. We established simple high-throughput optomotor response (OMR) assay utilizing medaka larvae functions including acuity contrast sensitivity. Our presents multiple adjustable stripes in motion individual linear arena. For that OMR employs tablet display Fish Stripes software adjust speed, width, color, stripes. results demonstrated responses were...
Type 4 P-type ATPases (P4-ATPases) function as phospholipid flippases, which translocate phospholipids from the exoplasmic leaflet to cytoplasmic of lipid bilayer, generate and maintain asymmetric distribution at plasma membrane endosomal/Golgi membranes. The budding yeast Saccharomyces cerevisiae has four heteromeric flippases (Drs2p, Dnf1p, Dnf2p, Dnf3p), associated with Cdc50p family noncatalytic subunit, one monomeric flippase, Neo1p. They have been suggested in vesicle formation...
Abstract Background The teleost medaka ( Oryzias latipes ) is a well-established vertebrate model system, with long history of genetic research, and multiple high-quality reference genomes available for several inbred strains. Medaka has high tolerance to inbreeding from the wild, thus allowing one establish lines wild founder individuals. Results We exploit this feature create an panel resource: Inbred Kiyosu-Karlsruhe (MIKK) panel. This 80 near-isogenic contains large amount variation...
Abstract Tea plants (Camellia sinensis L.) were hydroponically cultured for 9 d in a solution containing ammonium as sole nitrogen source (0 (control), 50, 100, or 200 mg N L-1 ), and harvested after 0 1,3,6, of treatments to investigate the effect on content metabolism oxalate tea plants. Total water-soluble contents young leaves roots treated with decreased proportion amount applied, levels significantly lower than those without application. In old leaves, both total showed constant values...
The Japanese species of the genus Paramerina Fittkau, 1962 are reviewed based on studies type material and specimens collected recently. Three species, P. kurobekogata Sasa et Okazawa, tokararesea Suzuki Krenopelopia amaminova Sasa, treated as synonyms, four yunouresia (Sasa), okigenga okimaculata togavicea (Sasa Okazawa), recognized valid. adults, males females, first two last pupa redescribed. pupae larvae larva described for time in this paper. Based examination holotype, morphological...
Abstract The teleost medaka ( Oryzias latipes ) is a well-established vertebrate model system, with long history of genetic research, and multiple high-quality reference genomes available for several inbred strains HdrR , HNI HSOK ). Medaka has high tolerance to inbreeding from the wild, thus allowing one establish lines wild founder individuals. We have exploited this feature create an panel resource: Inbred Kiyosu-Karlsruhe (MIKK) panel. This 80 near-isogenic contains large amount...
Abstract Medaka fish ( Oryzias latipes ) is a powerful model to study genetics underlying the developmental and functional traits of vertebrate visual system. We established simple high-throughput optomotor response (OMR) assay utilizing medaka larvae functions including acuity contrast sensitivity. Our presents multiple adjustable stripes in motion individual linear arena. For that OMR employs tablet display Fish Stripes software adjust speed, width, color, stripes. results demonstrated...
ABSTRACT At the last stage of blood coagulation cascade, thrombin plays a central role in processing fibrinogen for polymerization and additional activation Factor XIII stable cross-linking fibrin. In addition, carries out possible multiple roles via or interaction with various functional proteins. Several studies conducted order to elucidate physiological significance are ongoing. To clarify further establish an associated disease model, we characterized orthologue gene medaka (Oryzias...
Abstract Unraveling the relationship between genetic variation and phenotypic traits remains a fundamental challenge in biology. Mapping variants underlying complex while controlling for confounding environmental factors is often problematic. To address this, we have established vertebrate resource specifically to allow robust genotype-to-phenotype investigations. The teleost medaka ( Oryzias latipes ) an model system with long history of research high tolerance inbreeding from wild. Here...