A5067837325- 3D Printing in Biomedical Research
- Peroxisome Proliferator-Activated Receptors
- Metabolism and Genetic Disorders
- Additive Manufacturing and 3D Printing Technologies
- Pluripotent Stem Cells Research
- Plant biochemistry and biosynthesis
- Advanced biosensing and bioanalysis techniques
- Nonlinear Optical Materials Studies
- Microbial Metabolic Engineering and Bioproduction
- Tissue Engineering and Regenerative Medicine
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet and metabolism studies
- Cellular Mechanics and Interactions
- Lipid metabolism and biosynthesis
- Photochromic and Fluorescence Chemistry
- Bone Tissue Engineering Materials
- Retinal Development and Disorders
- Ocular Oncology and Treatments
Heidelberg University
2019-2024
Institute of Molecular Functional Materials
2024
University Hospital Heidelberg
2020
Retinal organoids have become important models for studying development and disease, yet stochastic heterogeneity in the formation of cell types, tissues, phenotypes remains a major challenge. This limits our ability to precisely experimentally address early developmental trajectories towards these outcomes. Here, we utilize deep learning predict differentiation path resulting tissues retinal well before they visually discernible. Our approach effectively bypasses challenge organoid-related...
Lipid droplets (LDs) are ubiquitous and highly dynamic subcellular organelles required for the storage of neutral lipids. LD number size distribution key parameters affected not only by nutrient supply but also lipotoxic stress metabolic regulation. Current methods quantification lack general applicability either based on time consuming manual evaluation or show limitations if LDs high in numbers closely clustered. Here, we present an ImageJ-based approach detection stained lipid dyes images...
Multi-photon 3D laser printing has gathered much attention in recent years as a means of manufacturing biocompatible scaffolds that can modify and guide cellular behavior vitro. However, vivo tissue engineering efforts have been limited so far to the implantation beforehand printed bioprinting constructs from bioinks containing cells, biomolecules, printable hydrogel formulations. Thus, comprehensive platform for situ microimplants raised synthetic polymer-based inks is currently missing....
Abstract Multi-photon 3D laser printing has gathered much attention in recent years as a means of manufacturing biocompatible scaffolds that can modify and guide cellular behavior vitro . However, vivo tissue engineering efforts have been limited so far to the implantation beforehand printed bioprinting constructs from bioinks containing cells, biomolecules, printable hydrogel formulations. Thus, comprehensive platform for situ microimplants raised synthetic polymer-based inks is currently...
Failure to thrive (FTT) causes significant morbidity, often without clear etiologies. Six individuals of a large consanguineous family presented in the neonatal period with recurrent vomiting and diarrhea, leading severe FTT. Standard diagnostic work up did not ascertain an etiology. Autozygosity mapping whole exome sequencing identified homozygosity for novel genetic variant long chain fatty acyl-CoA synthetase 5 (ACSL5) shared among affected (NM_203379.1:c.1358C>A:p.(Thr453Lys)). Autosomal...
Abstract Organoids have proven to be powerful in vitro model systems that mimic features of the corresponding tissue vivo . However, across types and species, organoids still often fail reach full maturity function, because biochemical cues cannot provided from within organoid guide their development. The establishment such tools has been identified as a major goal field. Here, we introduce DNA microbeads novel tool for implementing spatio-temporally controlled morphogen gradients inside at...