A5100395250- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Helicobacter pylori-related gastroenterology studies
- Islamic Finance and Banking Studies
- Gastrointestinal disorders and treatments
- Gut microbiota and health
- Inflammatory mediators and NSAID effects
- Estrogen and related hormone effects
- Liver Disease and Transplantation
- Thyroid Disorders and Treatments
- Cleft Lip and Palate Research
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Diverticular Disease and Complications
- Monoclonal and Polyclonal Antibodies Research
- Congenital Heart Disease Studies
- Biochemical effects in animals
- Neonatal Health and Biochemistry
- Peroxisome Proliferator-Activated Receptors
- Biosensors and Analytical Detection
- Colorectal Cancer Screening and Detection
- Advanced biosensing and bioanalysis techniques
- Heart Rate Variability and Autonomic Control
Ontario Institute for Cancer Research
2021-2024
Wayne State University
2021-2024
Zagazig University
2019-2024
Cairo University
2023-2024
Assiut University
2023-2024
University of Toronto
2022-2024
Universiti Malaysia Perlis
2017-2024
University of Halabja
2024
University of Manchester
2023
Matrix Research (United States)
2023
Recent evidence indicates a link between gut pathology and microbiome with hypertension (HTN) in animal models. However, whether this association exists humans is unknown. Thus, our objectives the present study were to test hypotheses that high blood pressure (BP) patients have distinct microbiomes gut-epithelial barrier function markers composition could predict systolic BP (SBP). Fecal samples, analyzed by shotgun metagenomics, displayed taxonomic functional changes, including altered...
DCAF1 is a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP), plays critical physiological role in protein degradation, considered drug target for various cancers. Antagonists could be used toward the development therapeutics cancers viral treatments. We WDR domain to screen 114-billion-compound DNA encoded library (DEL) identified candidate compounds using similarity search machine learning. This led discovery compound (Z1391232269) with an SPR KD 11 μM. Structure-guided...
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Catha edulis (khat) is a plant grown commonly in the horn of Africa. The leaves khat are chewed by people for its stimulant action. Khat an evergreen shrub, which cultivated as bush or small tree. have aromatic odour. taste astringent and slightly sweet. seedless hardy, growing variety climates soils. Khat contains more than 40 alkaloids, glycosides, tannins, amino acids, vitamins minerals. Many different compounds found including terpenoids, flavonoids, sterols, phenylalkylamines...
In many countries, routine data relating to growth of infants are collected as a means tracking health and illness up school age. These have potential be used in research. For monitoring research, should accurate reliable. This study aimed determine the agreement between length/height weight measurements from infant records researcher-collected data. Methods Height/length at ages 6, 12 24 months longitudinal UK birth cohort (born Bradford; n=836–1280) were compared with by visitors within 2...
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic in United States and globally. The currently understood model of pathogenesis consists a 'multiple hit' hypothesis which environmental genetic factors contribute to hepatic inflammation injury.To examine expression NAFLD non-alcoholic steatohepatitis (NASH) tissue samples identify pathways that NASH pathogenesis.We employed Search Tag Analyze Resource for Gene Expression Omnibus platform search National Center Biotechnology...
The choice between nodulectomy and lobectomy for managing thyroid nodules is a subject of debate in the field surgery. present study aims to share experience single center solitary through from January 2023 October 2023. inclusion criteria encompassed symptomatic or suspicious medically necessitated cases. extracted data included patient demographics, medical history, symptoms, diagnostic details, surgery indication, procedure outcome histopathological findings. follow-up clinic visits phone...
Proteolysis-targeting chimeras (PROTACs) have been explored for the degradation of drug targets more than two decades. However, only a handful E3 ligase substrate receptors efficiently used. Downregulation and mutation these would reduce effectiveness such PROTACs. We recently developed potent ligands DCAF1, receptor EDVP CUL4 ligases. Here, we focus on DCAF1 toward development PROTACs WDR5, target in various cancers. report four DCAF1-based with endogenous exogenous WDR5 effects...
The aim of this study was to evaluate the side effect Carbamazepine on histological structure thetestis in white mouse males.A total 24 male Swiss mice were divided into three groups, treated with Drugfor (30) days. Within each treatment period, animals assigned subgroups eight mice;control vehicle and others 200, 300mg/kg Carbamazepine, requireddose drug dosed orally for all once per day one month (30 days) two concentrations.At end treatments, sacrificed; Testes removed weighed then kept...
Failure to thrive (FTT) causes significant morbidity, often without clear etiologies. Six individuals of a large consanguineous family presented in the neonatal period with recurrent vomiting and diarrhea, leading severe FTT. Standard diagnostic work up did not ascertain an etiology. Autozygosity mapping whole exome sequencing identified homozygosity for novel genetic variant long chain fatty acyl-CoA synthetase 5 (ACSL5) shared among affected (NM_203379.1:c.1358C>A:p.(Thr453Lys)). Autosomal...
This study was carried out to determine and compare the phytochemical, anti-nutrients, proximate composition effects of Brassica oleracea varieties on hepatic erythropoietic parameters such as liver enzymes packed cell volume (PCV) respectively.Fresh samples different namely: oleracearepa(Chinese cabbage), oleracearupetris(red cabbage) oleraceapeviridis(green were collected from Kasa in Plateau state, Nigeria, identified.After authentication these samples, effect gastric inturbation (oral...
Background Blood pressure (BP) measurement is increasingly carried out through home or ambulatory monitoring, yet existing cardiovascular risk scores were developed for use with measurements obtained in clinics. Aim To describe differences estimates using BP instead of clinic readings. Design and setting Secondary analysis data from adults aged 25–84 years the UK Netherlands without prior history disease (CVD) two monitoring studies: Pressure different Ethnic groups (BP-Eth) study Home...
Background: From February April 2020, the COVID-19 pandemic has swept through more than 200 countries and infected 100 million individuals globally, posing an unprecedented threat to human health. There are currently no specific antiviral treatments for vaccination programs, whilst promising, remain in their infancy. A key restricting is ability minimize human-human transmission predict infection status of population face emerging SARS-CoV-2 variants. Success this area dependent on rapid...
Zinc oxide (ZnO) thin films this device to used for many application like chemical sensor, biosensor, solar energy, etc but my project use bioactivity(biosensor). have been grown using sol-gel technique. Characterization was done Scanning Electron Microscope (SEM), Energy Dispersive X-ray(EDX) and Electrical Measurement(I-V). ZnO film successfully synthesized low cost spin coating method. The coupling of DNA probe supports modified with carboxylic acid (COOH) is certainly the best practical...
The autosomal recessive cerebellar ataxias (ARCA) affect both the central and peripheral nervous systems. They are also characterized by a relatively high level of genetic heterogeneity with well over 40 genes already implicated. present study aimed to identify gene mutation responsible for complex phenotype comprising ataxia intellectual disability segregating in an Omani consanguineous family. Homozygosity-guided exome data analysis identified novel frameshift (c.2319_2322del) within...
Introduction: Anti Nuclear Antibodies are one of the auto antibodies which involved in screening, diagnosis and pathology some non autoimmune drug induced diseases including Lupus Erythrymatosus. Objectives: The aim this study is to investigate, if there any correlation between tamoxifen side effects blood levels as a consequence drug-induced lupus erythematosus. Methods: Twenty-eight breast cancer patients under therapy were compared 11 newly diagnosed who did not receive therapy. 5 mls...
Objectives The presence of postinstrumentation back pain in patients after undergoing spinal surgery is a well established phenomenon. So too the infection, both overt and subclinical which can be source pain. accurate assessment infection with implants situ no radiological or biochemical abnormalities frequently presents diagnostic challenge. We present our experience spanning 5 years using 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (18F FDG PET)-computed (CT) scans to aid...