A5017776580- Quinazolinone synthesis and applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Ionic liquids properties and applications
- Liver Disease Diagnosis and Treatment
- Multicomponent Synthesis of Heterocycles
- Synthesis and bioactivity of alkaloids
- Chemical synthesis and pharmacological studies
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Natural Antidiabetic Agents Studies
- Synthesis of heterocyclic compounds
- Chemical Synthesis and Reactions
- Peptidase Inhibition and Analysis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Cannabis and Cannabinoid Research
- Cytokine Signaling Pathways and Interactions
- Diet, Metabolism, and Disease
- Oxidative Organic Chemistry Reactions
- Synthesis and biological activity
- Biochemical and Molecular Research
- Diverse Scientific Research Studies
- Synthesis and Biological Evaluation
- Tuberculosis Research and Epidemiology
Ganpat University
2021-2023
Piramal (India)
2023
Maharaja Sayajirao University of Baroda
2012
DCAF1 is a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP), plays critical physiological role in protein degradation, considered drug target for various cancers. Antagonists could be used toward the development therapeutics cancers viral treatments. We WDR domain to screen 114-billion-compound DNA encoded library (DEL) identified candidate compounds using similarity search machine learning. This led discovery compound (Z1391232269) with an SPR KD 11 μM. Structure-guided...
In an effort to develop potent antithrombotic agents, a series of novel 2-aminobenzamide derivatives were synthesized and screened for their in vivo activity. Among the 23 compounds tested, compound (8g) showed most promising activity, which was comparable with clinically used aspirin or warfarin, but at variance these standard drugs, 8g did not exhibit increased bleeding time, suggesting its potential as agent.
Aim: A series of novel quinazolinone derivates was synthesized and assessed for their ability to inhibitory action on pancreatic lipase. The cyclization quinazolinone-4(3H)-one derivatives achieved, whereas carbon-carbon cross coupling reactions were carried out cyclized quinazolinone-4(3H)-one. This synthesis method afforded corresponding 2, 3 6 substituted quinazolin-4(3H)-ones (3a 3m) with moderate high yields.
 Methods: Benzamide (1a-1b) from anthranilic acid using acid-amine...
Diabetes mellitus is a metabolic condition characterised by chronic hyperglycaemia, and type II diabetes the most common type, accounting for 90% of cases globally. Hyperglycaemia major complication mellitus. Postprandial hyperglycaemia distinctive diabetes. Inhibition carbohydrate hydrolysing enzymes including amylase glucosidase may be useful method lowering postprandial blood sugar levels. Alpha inhibitors are approaching targets in development lead compounds treatment management This...
Aim: Novel quinazolin-4(3H)-one heterocycles were synthesized and assessed for their anti-diabetic activity. Non-enzymatic glycosylation of haemoglobin assay was carried out to identify potential as anti-diabetic. The cyclization quinazolinone-4(3H)-one achieved, whereas carbon-carbon cross coupling reactions using Sonogashira Suzuki-Miyaura reaction conditions characterized with analysis. This synthesis method afforded corresponding 2, 3 6 substituted quinazolin-4(3H)-ones (3a 3m) excellent...
Abstract The synthesis of biologically interesting title compounds with different ring size is best achieved by a reaction appropriate diamines BrCN in mixture DMSO and an ionic liquid.