A5001013964- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Renal Transplantation Outcomes and Treatments
- Cardiac Structural Anomalies and Repair
- Organ and Tissue Transplantation Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Polyomavirus and related diseases
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Xenotransplantation and immune response
- RNA Interference and Gene Delivery
- Cardiac Ischemia and Reperfusion
- Cardiac Valve Diseases and Treatments
- Cytomegalovirus and herpesvirus research
- Cardiac Arrest and Resuscitation
- T-cell and B-cell Immunology
- Cardiac and Coronary Surgery Techniques
- Neonatal Respiratory Health Research
- Congenital Heart Disease Studies
- Medical Imaging and Pathology Studies
University Hospital Schleswig-Holstein
2024-2025
University of Lübeck
2024-2025
University Hospital Heidelberg
2020-2024
Heidelberg University
2021-2024
German Centre for Cardiovascular Research
2020-2024
Kiel University
2024
Medizinische Hochschule Hannover
2014-2023
German Center for Lung Research
2014-2023
Chirurgische Universitätsklinik Heidelberg
2022
Methodist Hospital
2021
The use of extracorporeal membrane oxygenation (ECMO) in patients who are awake and spontaneously breathing may represent a novel bridging strategy toward lung transplantation (LuTx).To evaluate the outcomes treated with "awake ECMO" concept as bridge to transplantation.We performed retrospective, single-center, intention-to-treat analysis consecutive LuTx candidates terminal respiratory or cardiopulmonary failure receiving ECMO support. were compared historical control group conventional...
Abstract In recent years, SGLT2 inhibitors have become an integral part of heart failure therapy, and several mechanisms contributing to cardiorenal protection been identified. this study, we place special emphasis on the atria investigate acute electrophysiological effects dapagliflozin assess antiarrhythmic potential inhibitors. Direct were investigated in patch clamp experiments isolated atrial cardiomyocytes. Acute treatment with elevated-dose caused a significant reduction action...
We describe a novel technique of pumpless extracorporeal life support in four patients with cardiogenic shock due to end-stage pulmonary hypertension (PH) including veno-occlusive disease (PVOD) using lung assist device (LAD). The was connected via the arterial main trunk and left atrium, thereby creating septostomy-like shunt unique addition gas exchange abilities parallel lung. Using this approach, all were successfully bridged bilateral transplantation combined heart-lung transplantation,...
Bilateral lung transplantation (BLTx) is an established treatment for end-stage pulmonary hypertension (PH). Ventilator weaning failure and death are more common as in BLTx other indications. We hypothesized that left ventricular (LV) dysfunction the main cause of early postoperative morbidity or mortality investigated a strategy using awake venoarterial extracorporeal membrane oxygenation (ECMO).In 23 severe PH, ECMO used during was continued minimum 5 days (BLTx-ECMO group)....
<h3></h3> The European Paediatric Pulmonary Vascular Disease (PVD) Network is a registered, non-profit organisation that strives to define and develop effective, innovative diagnostic methods treatment options in all forms of paediatric pulmonary hypertensive vascular disease, including specific such as arterial hypertension (PAH)-congenital heart (PH) associated with bronchopulmonary dysplasia, persistent PH the newborn, related cardiac dysfunction. <h3>Methods</h3> writing group members...
(1) Objective: Bacterial resistance to conventional antibiotic therapy is an increasingly significant worldwide challenge human health. The objective evaluate whether bacteriophage could complement or be a viable alternative in critical cases of bacterial infection related cardiothoracic surgery. (2) Methods: Since September 2015, eight patients with multi-drug resistant especially recalcitrant Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Klebsiella pneumoniae, and...
Previous studies have demonstrated substantial genetic diversification of Pseudomonas aeruginosa across sub-compartments in cystic fibrosis (CF) lungs. Here, we isolate P. from five different sampling areas the upper and lower airways an explanted CF lung, analyze ex vivo transcriptional profiles by RNA-seq, use colony re-sequencing deep population sequencing to determine diversity within various sub-compartments. We find that, despite variation, populations inhabiting regions lung are...
ObjectiveTo clarify the relationship between use of extracorporeal life support during lung transplantation and severe primary graft dysfunction (PGD), we developed analyzed a novel multicenter international registry.MethodsThe Extracorporeal Life Support in Lung Transplantation Registry includes double-lung transplants performed at 8 high-volume centers (>40/year). Multiorgan were excluded. We defined PGD as grade 3 (PGD3) observed 48 or 72 hours after reperfusion. Modes no (off-pump),...
Chronic lung allograft dysfunction (CLAD) remains the leading cause of mortality in transplant recipients after first year. Treatment limited and unpredictable. Existing data suggests extracorporeal photopheresis (ECP) may be beneficial. This study aimed to identify factors predicting treatment response prognostic implications. A single center retrospective analysis all patients commencing ECP for CLAD between November 1, 2007 September 2011 was performed. In total 65 were included, 64 whom...
Short-term posttransplantation survival and health-related quality of life (HRQoL) is exceptionally high for all patients after organ transplantation; however, predictors the HRQoL outcome are not well understood. Trajectories patients' perceived benefit/burden ratio associated with transplant procedure may differ when taking type transplantation into account.A prospective, single-center cohort study assessed trajectories 354 kidney (n=165), liver (n=53), heart (n=24), lung (n=112) at 2, 6,...
Patients with respiratory failure may benefit from veno-venous and veno-arterial extracorporeal membrane oxygenation (ECMO) support. We report on our initial experience of veno-veno-arterial (v-v-a) ECMO in patients failure.Between January 2012 February 2014, 406 required support at institution. Here, we retrospectively analysed the characteristics outcomes commenced either or due to failure, then switched v-v-a ECMO.Ten (2%) proceeded ECMO. The underlying conditions were acute distress...
Acute pulmonary hypertension (PH) complicates the course of several cardiovascular, and other systemic diseases in children. An acute rise RV afterload, either as exacerbating chronic PH different aetiologies (eg, idiopathic arterial (PAH), lung or congenital heart disease), hypertensive crisis after corrective surgery for disease, may lead to severe circulatory compromise. Only few clinical studies provide evidence on how best treat children with decompensated function, that is, failure....