A5017218111- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Coronary Artery Anomalies
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Viral Infections and Immunology Research
- Cardiac pacing and defibrillation studies
- Organ Transplantation Techniques and Outcomes
- Vascular Anomalies and Treatments
- Cardiovascular Effects of Exercise
- Cardiovascular and Diving-Related Complications
- Vascular anomalies and interventions
- Neonatal Respiratory Health Research
- Hemodynamic Monitoring and Therapy
- Heart Rate Variability and Autonomic Control
- Nitric Oxide and Endothelin Effects
- Cardiomyopathy and Myosin Studies
Klinikum Stuttgart
2023-2025
University Children's Hospital Tübingen
2009-2025
Olgahospital
2022-2025
Deutsches Herzzentrum München
2015-2024
Technical University of Munich
2017-2023
Justus-Liebig-Universität Gießen
2012-2022
University Hospital Frankfurt
2021
Goethe University Frankfurt
2021
Cnopf´sche Kinderklinik
2021
München Klinik
2021
<h3></h3> The European Paediatric Pulmonary Vascular Disease (PVD) Network is a registered, non-profit organisation that strives to define and develop effective, innovative diagnostic methods treatment options in all forms of paediatric pulmonary hypertensive vascular disease, including specific such as arterial hypertension (PAH)-congenital heart (PH) associated with bronchopulmonary dysplasia, persistent PH the newborn, related cardiac dysfunction. <h3>Methods</h3> writing group members...
Childhood pulmonary hypertension (PH) is a heterogenous disease associated with considerable morbidity and mortality. Invasive assessment of haemodynamics crucial for accurate diagnosis guidance medical therapy. However, adequate imaging increasingly important in children PH to evaluate the right heart vasculature. Cardiac MR (CMR) computed tomography (CT) represent non-invasive modalities that may enable comprehensive ventricular (RV) function haemodynamics. Here, we present graded...
Different patterns of late gadolinium enhancement (LGE) including mid-wall fibrosis using cardiovascular magnetic resonance (CMR) have been reported in adult patients presenting with non-ischemic dilated cardiomyopathy (DCM). In these studies, LGE was associated pronounced LV remodelling and predicted adverse cardiac outcomes. Accordingly, the purpose our study to determine presence children adolescents DCM. Patients <18 years age severe congestive heart failure who were admitted for...
Residual right ventricular outflow tract (RVOT) obstruction (RVOTO) is considered beneficial in patients after repair of tetralogy Fallot (TOF) although underlying mechanisms are unknown. We sought to elucidate differences myocardial strain and dyssynchrony parameters TOF with without residual RVOTO using cardiovascular magnetic resonance (CMR) feature-tracking (CMR-FT) analysis. Fifty-four (mean age 16.4 ± 8.4 years) were assessed by CMR 14.2 7.3 years TOF. on echocardiography was defined...
Background Aortopulmonary collaterals (APCs) are frequently found in patients with a single-ventricle (SV) circulation. However, knowledge about the clinical significance of systemic-to-pulmonary shunt flow after modified Fontan procedure and its potential causes is limited. Accordingly, aim our study was to detect quantify APC using cardiovascular magnetic resonance (CMR) assess impact on SV volume function as well evaluate role size pulmonary arteries regard development APCs. Methods 60...
<h3>Background</h3> Restrictive right ventricular (RV) physiology is a phenomenon considered potentially beneficial when detected in children and adolescents with repaired tetralogy of Fallot (ToF). It typically characterised by antegrade flow the pulmonary artery late diastole at time atrial contraction. However, little known about impact restrictive on intrinsic diastolic RV function or lusitropy. <h3>Methods</h3> Diastolic was prospectively assessed baseline level during dobutamine...
Objectives We report our experience with a transcatheter technique to bypass the lung and thus improve single‐ventricle preload reduce venous congestion in Fontan patients. Background In absence of dedicated power source serve pulmonary circulation significantly elevated transpulmonary pressure gradient, fenestration is an option hemodynamics patients by relieving excessive systemic pressure. Methods Results From 2005 2011, 22 fenestrations were performed without any major complications 19...
Background Right ventricular outflow tract (RVOT) stenosis after repair of tetralogy Fallot has been linked with favorable right remodeling but adverse outcomes. The aim our study was to assess the hemodynamic impact and prognostic relevance pressure load in this population. Methods Results A total 296 patients repaired (mean age, 17.8±7.9 years) were included a prospective cardiovascular magnetic resonance multicenter study. Myocardial strain quantified by feature tracking technique at...
In patients with anomalous left coronary artery from the pulmonary (ALCAPA) ventricular (LV) dilatation and dysfunction evolves due to diminished myocardial perfusion caused by steal phenomenon. Using late gadolinium enhanced cardiovascular magnetic resonance (LGE-CMR) imaging, scarring has been shown in ALCAPA after repair, however incidence of before surgery its impact on postoperative course surgical repair remained unknown.
Objective Norwood and hybrid procedure are two options available for initial palliation of patients with hypoplastic left heart syndrome (HLHS). Our study aimed to assess potential differences in right ventricular (RV) function pulmonary artery dimensions using cardiac magnetic resonance (CMR) survivors HLHS. Methods 42 (mean age 2.4±0.8) 44 2.0±1.0 years) were evaluated by CMR after stage II prior planned Fontan completion. Initial I was performed a modified Blalock-Taussig shunt, while the...
Aims To quantitatively evaluate the basic pathophysiological process involved in creation of Eisenmenger syndrome pediatric pulmonary arterial hypertension (PAH) patients by either atrial septostomy (AS) or Potts shunt as well to predict effects AS future PAH patients. Methods The multi-scale lumped parameter CircAdapt model cardiovascular system was used investigate and on hemodynamics mechanics, oxygen distribution moderate severe PAH. reference simulation, with cardiac output set 2.1...
Pulmonary hypertension (PH) is frequently associated with an increase in sympathetic tone. This may adversely affect cardiac autonomic control. Knowledge about the clinical impact of dysfunction patients PH limited. We aimed to assess whether parameters heart rate variability (HRV) are related disease severity children PH.Parameters HRV [SDNN, standard deviation normal-to-normal intervals and SDANN, mean values for over 5 min] were determined from Holter electrocardiograms 17 without active...