A5027973116- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular and Diving-Related Complications
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Tissue Engineering and Regenerative Medicine
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
- Cardiovascular Conditions and Treatments
- Cardiac and Coronary Surgery Techniques
- Electrospun Nanofibers in Biomedical Applications
- Tracheal and airway disorders
- Atrial Fibrillation Management and Outcomes
- Cardiac tumors and thrombi
- Anesthesia and Neurotoxicity Research
- Central Venous Catheters and Hemodialysis
- Coronary Artery Anomalies
- Pulmonary Hypertension Research and Treatments
- Cardiac electrophysiology and arrhythmias
- Neonatal and fetal brain pathology
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Cardiomyopathy and Myosin Studies
Universitätsmedizin Göttingen
2011-2025
University of Göttingen
2015-2024
Technical University of Munich
2022
Deutsches Herzzentrum München
2009-2022
Center for Environmental Health
2022
Helmholtz Zentrum München
2022
University Medical Center
2022
University Hospital and Clinics
2022
Leipzig University
2022
Leipzig Heart Institute
2022
Introduction: Cryoenergy has evolved as a safe and effective alternative for ablation of arrhythmia substrates in adult patients. Due to two specific features, cryomapping cryoadhesion, this technique appears very attractive pediatric patients minimizing complications fluoroscopy time. The aim the study was investigate efficacy safety cryoenergy supraventricular tachycardia (SVT) Patients Methods: Thirty‐two (mean age: 10.1 ± 3.5 years) with SVT (accessory pathways: n = 19; atrioventricular...
This study examined the hypothesis that core temperature (T°) during cardiopulmonary bypass (CPB) influences perioperative systemic inflammatory response and post-operative organ damage. Twenty-four pigs were assigned to a T° regimen CPB: normothermia (T° 37°C; n = 8), moderate hypothermia 28°C; or deep 20°C; 8). Perioperative leukocyte activation, endotoxin release, production of tumor necrosis factor-α (TNFα) interleukin-10 (IL10) with regard damage, which was scored at histological...
Abstract New developments in stent technology led to the first biodegradable magnesium stents. To overcome fundamental restrictions of conventional implantation, these new stents may improve interventional therapy, also small children. What remains after complete degradation a is particular interest and concern. At autopsy, 2 months projected time 3.0 × 10 mm stent, no solid compounds were detected, vessel diameter had increased slightly 3.7 mm. Histological preparation revealed an amorphous...
Despite their clinical introduction 10 years ago, no human series on the healing response to Amplatzer and Starflex devices in humans have been reported yet. We sought investigate biocompatibility of Cardioseal/Starflex septal occluder compare findings results experimental animals.The (n = 12, follow-up periods from 5 days 4 years) animals 32, 1 year) was studied using a uniform work up protocol. Histological sections paraffin-wax-embedded or methacrylate-embedded specimen scanning electron...
We sought to evaluate tissue reactions within and at the surface of devices for interventional therapy septal defects identify antigen characteristics neotissues.Atrial or ventricular defect-occlusion (Amplatzer, n=7; Cardioseal/Starflex, n=3) were processed using a uniform protocol after surgical removal from humans (implantation time, 5 days 4 years). Devices fixed in formalin embedded methylmethacrylate. Serial sections obtained by sectioning with diamond cutter grinding, thus saving...
<b><i>Background/Aims:</i></b> In adults, plasma exchange (PE) has been shown to be an efficient treatment for severe relapses of acute inflammatory CNS demyelinating diseases. The aim this study was evaluate the safety and efficacy in pediatric patients. <b><i>Methods:</i></b> We retrospectively analyzed a single-center cohort patients with disorders who underwent apheresis between 2007 2011. <b><i>Results:</i></b> Ten...
The objective was to implant a stented decellularised tissue-engineered heart valve (sdTEHV) percutaneously in an animal model, assess its vivo functionality and examine the repopulation remodelling of valvular matrix by recipient's autologous cells.Prototypes sdTEHV were cultured vitro, implanted into pulmonary position 15 sheep. Functionality assessed monthly intracardiac echocardiography (ICE). Valves explanted after eight, 16 or 24 weeks analysed macroscopically, histologically electron...
In the search for a biodegradable device that leaves nothing but tissue of patient after complete endotheliazation and absorption, BioSTAR® was introduced in 2007 (CE Mark European community HPB Canada) ASD PFO closure. It consists metal framework covered by membrane generated from layer porcine collagen is broken down absorbed over time. sheep model, results were promising, showing closure defect with degradation approximately 90% implanted material two years.We report retrospective...
Current materials for closure of cardiac defects such as ventricular septal (VSDs) are associated with compliance mismatch and a chronic inflammatory response. Bacterial nanocellulose (BNC) is non-degradable biomaterial promising properties high mechanical strength, favourable elasticity negligible reaction. The aim this study was the evaluation BNC patch VSD investigation its in vivo biocompatibility pig model. Young's modulus tensile strength patches were determined before after blood...
Background Right ventricular outflow tract (RVOT) stenosis after repair of tetralogy Fallot has been linked with favorable right remodeling but adverse outcomes. The aim our study was to assess the hemodynamic impact and prognostic relevance pressure load in this population. Methods Results A total 296 patients repaired (mean age, 17.8±7.9 years) were included a prospective cardiovascular magnetic resonance multicenter study. Myocardial strain quantified by feature tracking technique at...
Aims:The aim of this study was to evaluate local biological responses the partially bioresorbable nonmetal frame Carag septal occluder system in an experimental setting. Methods and results:A Good Laboratory Practices (GLP) performed with implantation device into interatrial septum 24 German Landrace pigs follow-up periods 3, 5, 8 15 months (six animals each group).One non-implant-related death occurred one month after implantation.Histology obtained by sawing grinding hard-resin embedded...
Transcatheter treatment of aortic coarctation (CoA) via stent implantation has become an established option depending on the patient's age and CoA type.The Osypka BabyStent(®) is a low-profiled, balloon-expandable cobalt-chrome to treat in infants, which breakable permit unrestricted growth. We hereby evaluated our initial clinical experience demonstrate feasibility efficacy this new nonlicensed device, we have occasionally implanted critically ill patients or when redo-surgery would entail...
Creation of a systemic-to-pulmonary shunt is still the firstline treatment in neonates with duct-dependent pulmonary circulation, or patients hypoplastic left heart syndrome as part first stage Norwood sequence. Acute complications after such surgery, stenosis, thrombosis, kinking, are potentially lifethreatening. These require immediate revision exchange shunt. In this report, we discuss interventional an alternative to surgery 5 acute stenosis complete occlusion The age ranged from 12 62...
Background: Animal studies and clinical observations have demonstrated that radiofrequency current application at growing myocardium may result in coronary artery obstruction. Recently, cryoenergy has emerged as an effective alternative to ablation of arrhythmogenic substrates pediatric patients. Up now, there been a lack experimental data concerning the effects myocardium. Methods: During general anesthesia, selective angiography right left was performed 10 piglets (age: 6 weeks, body...
Different types of patch materials are used for aortic valve repair in children with congenital disease to avoid early replacement. CardioCel© (Admedus, Toowong, QLD, Australia) consists bovine pericardium treated the ADAPT method (Admedus' proprietary tissue engineering process).Our goal was describe reactions 12 explanted leaflet specimens (augmented or replaced CardioCel material) (11 surgically, 1 autopsy). Explantation performed during reoperation after repair, necessitated by stenosis...
Head development is a surrogate for brain in infants and related to neurocognitive outcome. There only limited knowledge on early extra-uterine head shape size assessment very preterm infants. Here, 26 with mean gestational age of 29.1 ± 2.2 weeks birth weight 1273.8 427.7 g underwent serial stereophotogrammetric 3D imaging weekly intervals from term-equivalent age. The main outcome was the longitudinal 'physiological' cephalometric (head circumference, cranial volume) parameters (cranial...