A5089953709- Cardiac Valve Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Venous Thromboembolism Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Acute Myocardial Infarction Research
- Cardiomyopathy and Myosin Studies
- Aortic Disease and Treatment Approaches
- Cardiovascular Health and Disease Prevention
- Elasticity and Material Modeling
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
Deutsches Herzzentrum der Charité
2013-2018
Charité - Universitätsmedizin Berlin
2018
German Centre for Cardiovascular Research
2018
Deutsches Herzzentrum München
2014-2015
Computational modeling–inspired heart valve designs guide tissue remodeling and ensure long-term functionality in tissue-engineered valves sheep.
The objective was to implant a stented decellularised tissue-engineered heart valve (sdTEHV) percutaneously in an animal model, assess its vivo functionality and examine the repopulation remodelling of valvular matrix by recipient's autologous cells.Prototypes sdTEHV were cultured vitro, implanted into pulmonary position 15 sheep. Functionality assessed monthly intracardiac echocardiography (ICE). Valves explanted after eight, 16 or 24 weeks analysed macroscopically, histologically electron...
Aims There are significant variations in the published normal values of two‐dimensional speckle tracking–derived strain and rate. These occur even when authors use same software. To measure strain, operator creates a region interest ( ROI ) to define myocardium be analyzed. The purpose this study was test hypothesis that measurements vary significantly with chosen width. Methods Results In 20 healthy subjects (11 males, mean age 17.6 ± 6.18 years) an apical four‐chamber view (4 CH...
Many congenital heart defects and degenerative valve diseases require replacement of valves in children young adults. Transcatheter xenografts degenerate over time. Tissue engineering might help to overcome this limitation by providing with ability for self-repair. A transcatheter decellularized tissue-engineered (dTEHV) was developed using a polyglycolic acid (PGA) scaffold. first prototype showed progressive regurgitation after 6 months in-vivo due suboptimal design misguided remodeling...
Background: Ovine models are widely used in cardiovascular research because of their comparability to the human system. Sheep well available, easy handle, mostly indulgent and anesthesia is similar comparison with humans. Nevertheless, differences known concerning composition blood constituents rheological properties as oral administration resorption some drugs. Amongst those, platelet inhibitors, vitamin K antagonists low molecular weight heparin (LMWH) exhibit different pharmacodynamics....
Background: Transcatheter valve prostheses degenerate over time. Tissue engineering might overcome this limitation by providing valves with abilities for self-repair. In a European consortium, transcatheter decellularized tissue-engineered heart (dTEHV) was developed. A first prototype showed progressive regurgitation in vivo due to suboptimal design. Currently an optimized second generation is under investigation.
Introduction: In the scope of LifeValve-project, a new delivery system for transvenous pulmonary valve implantation was developed. Both decellularized tissue-engineered (n = 35) or pericardial valves 13) sewn into self-expandable Nitinol-stents were used. Sheep anatomy required jugular access these valves.
Introduction: To implement speckle tracking-derived global longitudinal and circumferential strain (GSL, GSC) in daily clinical practice, it is crucial to identify factors which are influencing the reliability of measurements. obtain GSL GSC, a region interest (ROI) has be created. The operator selects width include whole LV myocardium while excluding pericardium. purpose this study test hypothesis that ROI has, itself, significant influence on measured values.
Objectives: Many congenital heart defects and degenerative valve diseases require replacement of valves in children young adults. Transcatheter xenografts degenerate over time. Tissue engineering might overcome this limitation by providing with ability for self-repair. In a European consortium, transcatheter decellularized tissue-engineered (dTEHV) was developed. A first prototype showed progressive regurgitation after 6 months vivo due to suboptimal design. Here we present the second...