A5107978579- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- MRI in cancer diagnosis
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Electron Spin Resonance Studies
- Spine and Intervertebral Disc Pathology
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Medical Imaging Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Glioma Diagnosis and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Magnetism in coordination complexes
- Bone and Joint Diseases
- Musculoskeletal pain and rehabilitation
- Atomic and Subatomic Physics Research
- Mechanical Circulatory Support Devices
- Neurosurgical Procedures and Complications
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Knee injuries and reconstruction techniques
- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Disease and Adiposity
LifeBridge Health
2023
Siemens Healthcare (Germany)
2014-2022
Berlin Heart (Germany)
2021
Siemens (Australia)
2015-2020
Siemens Healthcare (United States)
2020
Deutsches Herzzentrum München
2015-2019
Deutsches Herzzentrum der Charité
2019
German Centre for Cardiovascular Research
2019
Berlin-Brandenburger Centrum für Regenerative Therapien
2019
Heidelberg University
2011-2017
Purpose To compare a glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging method, which enables sampling of the water signal as function presaturation offset (z-spectrum) at 13 points in clinically feasible times, with sodium 23 (23Na) magnetic resonance (MR) patients after cartilage repair surgery (matrix-associated autologous chondrocyte transplantation and microfracture therapy). Materials Methods One female patient (67.3 years), 11 male (median age, 28.8 years;...
The aim of this study was to compare quantitative and semiquantitative parameters (signal-to-noise ratio [SNR], contrast-to-noise [CNR], image quality, diagnostic confidence) from a standard brain magnetic resonance imaging examination encompassing common neurological disorders such as demyelinating disease, gliomas, cerebrovascular epilepsy, with comparable sequence protocols acquisition times at 3 T 7 T.Ten healthy volunteers 4 subgroups 40 patients in total underwent diffusion-weighted...
Abstract Chemical exchange saturation transfer (CEST) imaging depends on the performance of radiofrequency during experiment. Scanner specifications, in particular limited pulse width and duty‐cycle, specific absorption rate guidelines restrict full exploitation CEST effects clinical MR systems. The purpose this study was to optimize techniques for effective train presaturation a whole‐body scanner. Theoretical analysis simulations spectral properties trains demonstrated significance τ P...
// Yan Bai 1,* , Yusong Lin 2,* Wei Zhang 3 Lingfei Kong 4 Lifu Wang Panli Zuo 5 Ignacio Vallines 6 Benjamin Schmitt 7 Jie Tian 8 Xiaolei Song 9 Jinyuan Zhou and Meiyun 1 Department of Radiology, Zhengzhou University People's Hospital & Henan Provincial Hospital, Zhengzhou, Henan, China 2 Cooperative Innovation Center Internet Healthcare School Software Applied Technology, University, Ren Ji Shanghai Jiao Tong Shanghai, Pathology, MR Collaborations NE Asia, Siemens China, Beijing, Imaging...
Accurate glioma classification affects patient management and is challenging on non- or low-enhancing gliomas. This study investigated the clinical value of different chemical exchange saturation transfer (CEST) metrics for assessed diagnostic effect presence abundant fluid in subpopulations.Forty-five treatment-naïve patients with known isocitrate dehydrogenase (IDH) mutation 1p/19q codeletion status received CEST MRI (B1rms = 2μT, Tsat 3.5 s) at 3 T. Magnetization ratio asymmetry (amides:...
To assess the clinical feasibility of a compressed sensing cine magnetic resonance imaging (MRI) sequence both high temporal and spatial resolution (CS_bSSFP) in comparison to balanced steady-state free precession (bSSFP) for reliable quantification left ventricular (LV) volumes mass.Segmented MRI images were acquired on 1.5T scanner 50 patients LV short-axis stack orientation using retrospectively gated conventional bSSFP (generalized autocalibrating partially parallel acquisition [GRAPPA]...
To evaluate the feasibility to detect and delineate malignant breast lesions in human patients by chemical exchange saturation transfer (CEST) as an MR imaging technique without need for contrast agent administration.Six female referred pre-surgical staging due histologically confirmed cancer were examined with at 3 T. The routine protocol included T (2w), STIR, (1w)-DCE contrast-enhanced (1w) SPAIR fat suppression. For CEST imaging, a 3D RF-spoiled gradient echo (GRE) sequence optimized...
To analyze age-dependency of glycosaminoglycan content using gagCEST (glycosaminoglycan chemical exchange saturation transfer) imaging in lumbar intervertebral discs healthy volunteers.In all, 70 volunteers without low back pain (mean age 44 ± 14 years, range: 21-69 years) were examined with T2 -weighted and a 3T MR scanner, approval the local Ethics Committee after written informed consent was obtained. Pfirrmann grading classification into bulging herniation, bulging, herniation performed....
Objective The aim of this study was to compare quantitative and semiquantitative parameters (signal-to-noise ratio [SNR] diagnostic confidence) from a standard knee magnetic resonance imaging (MRI) examination with comparable sequence protocols acquisition times at 3 T 7 T. Materials Methods Forty patients experiencing pain unknown etiology underwent MR turbo-spin echo short tau inversion recovery sequences the joint (5 sequences) For analysis, SNR determined using these 5 additional...
Evaluation of a new quantitative imaging technique in prospective study design.To assess glycosaminoglycan (GAG) content lumbar intervertebral discs (IVDs) healthy volunteers with chemical exchange saturation transfer (CEST).Biochemical alterations are present before the appearance morphological changes. GAG loss plays central role these degenerative processes.Lumbar controls (26 women, 22 men; mean age 31 ± 8 years; range: 21-49 years) without back pain were examined at 3 Tesla magnetic...
To assess glycosaminoglycan (GAG) content of lumbar intervertebral discs (IVD) in patients with spondyloarthritis (SpA) using chemical exchange saturation transfer (gagCEST).Ninety nine SpA and age-matched healthy controls (eight ankylosing spondylitis; one patient spondylitis related to inflammatory bowel disease; mean age: 44.1 ± 14.0 years; range: 27-72 years) were examined a 3T magnetic resonance imaging (MRI) scanner this prospective study. The MRI protocol included standard...
Purpose To mitigate inhomogeneity in quantitative CEST MRI at ultra‐high magnetic field strengths (B 0 ≥ 7 Tesla) using a parallel transmit system. Methods Multiple interleaved mode saturation employs interleaving of 2 complementary phase sets during the pulse train. Phase differences 45° (first mode) and 90° (second between adjacent transmitter coil channels are used. The influence new scheme on contrast was analyzed Bloch‐McConnell simulations. presented method verified phantom vivo...
Purpose To assess the performance, in presence of scanner instabilities, three dynamic correction methods which integrate ∆ B 0 mapping into chemical exchange saturation transfer (CEST) measurement and established static ‐correction approaches. Methods A homogeneous phantom five healthy volunteers were scanned with a CEST sequence at 7 T. The vivo measurements performed twice: first unaltered system frequency again applying shifts during acquisition. In all cases, retrospective voxel‐wise...