A5036767918- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurology and Historical Studies
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Brain Metastases and Treatment
- Advanced MRI Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Head and Neck Surgical Oncology
- Spinal Fractures and Fixation Techniques
- History of Medical Practice
- Cerebral Venous Sinus Thrombosis
- Bone Tumor Diagnosis and Treatments
- S100 Proteins and Annexins
- Surgical Simulation and Training
- Acute Ischemic Stroke Management
- Trigeminal Neuralgia and Treatments
- Advanced Neuroimaging Techniques and Applications
- Moyamoya disease diagnosis and treatment
National Hospital for Neurology and Neurosurgery
2015-2024
University College London
2015-2024
Queen Square Radiosurgery Centre
2019-2024
University College London Hospitals NHS Foundation Trust
2017-2024
Royal London Hospital
2021-2023
Victor (Japan)
2005-2022
James Cook University Hospital
2017-2020
King's College Hospital NHS Foundation Trust
2017-2020
University Hospital Southampton NHS Foundation Trust
2017-2020
Royal Marsden Hospital
2018
Background: IDH-wildtype glioblastoma is the most common malignant primary brain tumour in adults. As there limited information on prognostic factors outside of clinical trials; thus, we conducted a retrospective study to characterise population at our centre. Methods: Demographic, molecular profiles, treatment, and survival data were collated for patients diagnosed with centre between July 2011 December 2015. We used multivariate proportional hazard model associations survival. Results: 490...
This prospective study was conducted to quantify brain shifts during open cranial surgery, determine correlations between these and image characteristics, assess the impact of postimaging distortion on neuronavigation.During 48 operations, movements cortex opening, deep tumor margin, at completion were measured relative preoperative position with aid an image-guidance system. Bone surface offset used system accuracy correct for registration errors. Preoperative images examined presence edema...
An automatic method for the accurate registration of computed tomography (CT) data with two camera‐calibrated radiographs is presented. The based on skull as visualized both in plain and digitally reconstructed from CT. A reference coordinate system established radiographic projection parameters obtained using an angiographic stereotactic localizer. CT‐derived are aligned iteratively at multiple resolutions until a best match found by adjusting position orientation CT set relative to system....
Visual inspection and volumetric analysis of MRIs allow mesial temporal sclerosis (MTS) to be reliably identified in patients with lobe epilepsy. The presence unilateral MTS ipsilateral the side habitual seizure onset is an indicator for prognosis good outcome after resection. There evidence suggest that widespread pathology, leading atrophy, may associated such abnormal tissue play important role epileptogenesis. We have analysed quantitatively volumes lateral substructures from 62...
The international guidelines for the diagnosis of normal pressure hydrocephalus (NPH) define ventricular enlargement as Evans' index greater than 0.3.To establish whether there is a correlation between and volume (VV) in NPH choosing different planes measurements could produce significantly results.Pre-shunt insertion, thin-section CT scans brains 10 patients with shunt-responsive were reviewed retrospectively, measuring index, frontal horn VV, total intracranial (ICV)....
Object Hemangiopericytomas are rare tumors that behave aggressively with a high rate of local recurrence and distant metastases. With the aim determining outcome response to various treatment modalities, series 39 patients who underwent microsurgical resection for primary meningeal hemangiopericytoma over 24-year period is presented. Methods Patients were identified from histopathology records their medical analyzed retrospectively by 2 independent reviewers collect data on surgical...
Automatic segmentation of vestibular schwannomas (VSs) from MRI could significantly improve clinical workflow and assist in patient management. Accurate tumor volumetric measurements provide the best indicators to detect subtle VS growth, but current techniques are labor intensive dedicated software is not readily available within setting. The authors aim develop a novel artificial intelligence (AI) framework be embedded routine for automatic delineation volumetry VS.
Automatic segmentation of vestibular schwannomas (VS) from magnetic resonance imaging (MRI) could significantly improve clinical workflow and assist patient management. We have previously developed a novel artificial intelligence framework based on 2.5D convolutional neural network achieving excellent results equivalent to those achieved by an independent human annotator. Here, we provide the first publicly-available annotated dataset VS releasing data annotations used in our prior work....
<h3>Importance</h3> Trials often assess primary outcomes of traumatic brain injury at 6 months. Longer-term data are needed to for patients receiving surgical vs medical treatment intracranial hypertension. <h3>Objective</h3> To evaluate 24-month with hypertension treated decompressive craniectomy or standard care. <h3>Design, Setting, and Participants</h3> Prespecified secondary analysis the Randomized Evaluation Surgery With Craniectomy Uncontrollable Elevation Intracranial Pressure...
Several factors are known to increase the risk of subarachnoid hemorrhage (SAH) and spontaneous intracerebral hematoma. However, information on roles these same in formation multiple aneurysms is less well defined. The purpose this study was examine associated with an increased aneurysm formation.A retrospective review medical records all patients a diagnosis SAH intracranial who were admitted single institution between 1985 1997 undertaken. authors examined associations (patient age sex,...
Dysembryoplastic neuroepithelial tumour (DNT) is a newly recognized brain mass lesion with distinctive pathological features and favourable prognosis. We reviewed the clinical, electroencephalographic, neuroimaging of 16 patients DNT who underwent surgery; only one patient did not have epilepsy. Mean age at seizure onset was 9.5 years (range: 1 week to 30 years) surgery 17 7 months 37 years). The mean verbal IQ 94.6 79-110) performance 105 79-130) (n = 10). EEG abnormal in all cases 13):...
✓ The authors present the results of accuracy measurements, obtained in both laboratory phantom studies and an vivo assessment, for a technique frameless stereotaxy. An instrument holder was developed to facilitate stereotactic guidance enable introduction methods traditional frame-based procedures. stereotaxy assessed images acquired using 0.5-tesla or 1.5-tesla magnetic resonance (MR) imaging 2-mm axial, 3-mm helical computerized tomography (CT) scanning. A clinical series is reported...
We performed conventional T2-weighted brain MRI examinations in six patients with multiple sclerosis (MS) and trigeminal neuralgia. In all brainstem lesions positions expected to involve fibers, particularly the entry zone of sensory were demonstrated. Compression nerve by ectatic vessels, a recognized cause idiopathic neuralgia, was not observed. conclude that MS neuralgia is usually caused demyelinating affecting pontine pathways.
This study was undertaken to assess the reliability of aspect ratio (AR) (i.e., aneurysm depth neck) in predicting rupture. It has been shown that AR is a key factor intraaneurysmal blood flow and rupture.Seventy-five patients with subarachnoid hemorrhage multiple aneurysms were studied. The sizes their ARs determined by examining angiographic films. By comparing difference between ruptured unruptured same individual, each patient effect served as his or her own control. Each confirmed...
Abstract Despite meticulous preoperative assessment, about 30% of patients with refractory partial epilepsy due to hippocampal sclerosis fail become seizure free after appropriate temporal lobe surgery. Perioperative complications, remnants, and bitemporal disease do not account for all failures; extrahippocampal epileptogenic tissue must persist in some patients. Such dual pathology is detected on routine visual inspection magnetic resonance images 15% sclerosis, but most such are excluded...
Free-hand insertion of an external ventricular drain (EVD) is a common emergency neurosurgical procedure, mostly performed for critically ill patients. Although EVD complications have been studied thoroughly, the accuracy positioning has audited only occasionally.Post-EVD computed tomographic scans in our unit over 2-year period were analyzed tip location and intracranial catheter length.A total 183 post-EVD reviewed. Of those, 73 tips (39.9%) ipsilateral frontal horn lateral ventricle (the...
Traumatic brain injury causes diffuse axonal and loss of cortical neurons. These features are well recognized histologically, but their in vivo monitoring remains challenging. In microdialysis samples the extracellular fluid adjacent to neurons axons. Here, we describe a novel neuronal proteolytic pathway demonstrate exclusive neuro-axonal expression Pavlov's enterokinase. Enterokinase is membrane bound cleaves neurofilament heavy chain at positions 476 986. Using 100 kDa cut-off two...
As inspired oxygen availability falls with ascent to altitude, some individuals develop high-altitude headache (HAH). We postulated that HAH results when hypoxia-associated increases in cerebral blood flow occur the context of restricted venous drainage, and is worsened compliance reduced. explored this hypothesis 3 studies.In studies, retinal distension (RVD) was ophthalmoscopically assessed 24 subjects (6 female) sea-level cranial magnetic resonance imaging performed 12 ascending 5,300m....
OBJECTIVE Although interactive image guidance has been determined to be an increasingly important and reliable tool in contemporary neurosurgery, the clinical results cost-effectiveness of use these systems, compared with conventional techniques, remain understudied. The aim this study was investigate possible benefits image-guided craniotomies treat meningiomas, terms hospital stays, surgical complications, and, consequently, cost-effectiveness, standard surgery (SS). METHODS During a...