A5069033132- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Infectious Encephalopathies and Encephalitis
- Neurology and Historical Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Glioma Diagnosis and Treatment
- Genomics and Rare Diseases
- Neurological and metabolic disorders
- Genetics and Neurodevelopmental Disorders
- Pharmaceutical studies and practices
- Mitochondrial Function and Pathology
- Cerebrospinal fluid and hydrocephalus
- Autoimmune Neurological Disorders and Treatments
- Drug Transport and Resistance Mechanisms
- EEG and Brain-Computer Interfaces
- Hemoglobinopathies and Related Disorders
- Historical Psychiatry and Medical Practices
- Glycogen Storage Diseases and Myoclonus
University College London
2013-2024
National Hospital for Neurology and Neurosurgery
2012-2024
Bridge University
2019
University of Cambridge
1981-2019
Paracelsus Medical University
2013-2016
University of Verona
2016
UCL Biomedical Research Centre
2013-2016
Transnational Press London
2014
University of London
1993-2013
Epilepsy Society
1996-2013
The most common temporal lobe pathology is Ammons Horn sclerosis (AHS), and several different imaging techniques have been utilized to detect this with varying success We describe the clinical application of magnetic resonance (MRI) using a three-dimensional volume technique which allows total hippocampal be measured symmetry evaluated. Hippocampal surface area was calculated in sequential 1.5 mm thick contiguous images, GE IC workstation. Total volumes areas were calculated. cross-sectional...
Summary: Purpose : To evaluate the efficacy and tolerability of levetiracetam (LEV, Keppra) as add‐on therapy in patients with refractory partial seizures. Methods In this European multicenter, double‐blind, randomized, placebo‐controlled trial, LEV (500 or 1,000 mg twice daily) was compared placebo 324 uncontrolled simple complex seizures, both, without secondary generalization. After enrollment, three parallel groups were assessed during a baseline period 8 12 weeks, followed by 4‐week...
The objective of the current article was to review literature and discuss degree evidence for various treatment strategies status epilepticus (SE) in adults. We searched MEDLINE EMBASE relevant from 1966 January 2005 updated version all pertinent publications 2009. Furthermore, Cochrane Central Register Controlled Trials (CENTRAL) sought. Recommendations are based on this our judgement relevance references subject. were reached by informative consensus approach. Where there a lack but clear,...
Phenytoin and carbamazepine are effective inexpensive anti-epileptic drugs (AEDs). As with many AEDs, a broad range of doses is used, the final “maintenance” dose normally determined by trial error. Although genes could influence response to these medicines, there obvious candidates. Both target α-subunit sodium channel, encoded SCN family genes. principally metabolized CYP2C9, both probable substrates drug transporter P-glycoprotein. We therefore assessed whether variation in associates...
It has long been known that the response to treatment in newly diagnosed epilepsy is better than chronic epilepsy. However, past 15 years, 8 major new antiepileptic drugs have licensed, and effect of this wider range options on prognosis not fully assessed. The aim study was quantify adding a previously unused drug regimen adults with uncontrolled had resistant previous treatment.A total 265 additions were studied 155 adult patients (defined as active at least 5 years after initiation...
Three phase III studies (304 [ClinicalTrials.gov identifier: NCT00699972], 305 [NCT00699582], 306 [NCT00700310]) evaluated perampanel, an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, as adjunctive therapy for refractory partial seizures. We report post hoc analyses of pooled study data by randomized dose.Patients with seizures despite receiving 1-3 antiepileptic drugs were to once-daily placebo, perampanel 8 or 12 mg (studies 304, 305), 2, 4, (study 306)....
People with epilepsy have an increased risk of premature death. The is highest soon after onset seizures. We report the findings a long-term follow-up population-based study people regards to mortality. National General Practice Study Epilepsy prospective flagged at Health Service Information Centre in UK. Over 1000 new seizures were followed from mid 1980s until April 2009. Of these, 564 classified 6 months as having definite epileptic seizures, 228 possible and 220 febrile remainder...
OBJECTIVE--To record non-invasively ictal cardiorespiratory variables. METHODS--Techniques employed in polysomnography were used patients with epilepsy undergoing EEG-video recording at a telemetry unit. RESULTS--Apnoea (> 10, range > 10-63, mean 24 s) was seen 20 of 47 clinical seizures (three secondary generalised, 16 complex partial, and one tonic) 10 17 patients. Apnoea central patients, but obstructive apnoea also recorded three 10. Oxyhaemoglobin saturation (SpO2) dropped to less...
The United Kingdom National General Practice Study of Epilepsy is a prospective, population-based study newly diagnosed epilepsy. A cohort 792 patients has now been followed for up to 14 years (median follow-up [25th, 75th percentiles] 11.8 years, range 10.6-11.7 years), total 11,400 person-years. These data are sufficient detailed analysis mortality in this early phase Over 70% have developed lasting remission from seizures, although the rate long term was still twice that general...
A total of 110 patients underwent diagnostic evaluation for attacks uncertain origin by means video-EEG telemetry and had a diagnosis pseudoseizures confirmed. Eighty-six (78%) were female, mean age onset 25 years, duration was 3 years. Many the erroneously been thought to be suffering from epilepsy. The could divided into two broad categories: collapse (one-third) with prominent motor activity (two-thirds). In some patients, associated incontinence injury. differential clinical features are...
The differentiation of frontal lobe epilepsy (FLE) and temporal (TLE) is a clinical problem major theoretical practical importance. Current electroclinical classification based on retrospective studies highly selected patients. When applied to the presurgical evaluation patients, it has poor specificity. current study adopts different prospective approach analysis ictal manifestations their value in differentiating FLE TLE. Two hundred fifty-two patients with partial were according criteria...
Sudden death, often seizure related, may occur in patients with epilepsy. Population-based incidence is probably on the order of 1:1,000/year. The much higher selected groups, however. We wished to establish sudden unexpected death (SUD) a young cohort severe epilepsy and learning difficulties. study included 310 pupils enrolled at special residential school between April 1970 1993. follow-up period totaling 4,135 person-years residence as well time after leaving. Age sex standardized...