A5010586930- Respiratory Support and Mechanisms
- CRISPR and Genetic Engineering
- High Altitude and Hypoxia
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Heme Oxygenase-1 and Carbon Monoxide
- Biotechnology and Related Fields
- Chromosomal and Genetic Variations
- Traumatic Brain Injury and Neurovascular Disturbances
- Biomedical Ethics and Regulation
- Neuroscience of respiration and sleep
- Genomics and Rare Diseases
University College London
2012-2016
University of Oxford
2014-2016
St Peter's Hospital
2016
Queen Mary University of London
2014
As inspired oxygen availability falls with ascent to altitude, some individuals develop high-altitude headache (HAH). We postulated that HAH results when hypoxia-associated increases in cerebral blood flow occur the context of restricted venous drainage, and is worsened compliance reduced. explored this hypothesis 3 studies.In studies, retinal distension (RVD) was ophthalmoscopically assessed 24 subjects (6 female) sea-level cranial magnetic resonance imaging performed 12 ascending 5,300m....
We hypothesised that the airway resistance during tidal breathing would correlate with a particular pattern of increasing obesity, particularly when supine, and differ between participants without ventilatory failure.In our cross-sectional cohort study, 72 morbidly obese patients (40 males, 32 females, mean body mass index (BMI) 47.2) had measurements both airways (by impulse oscillometry (IOS)) adiposity dual-energy X-ray absorptiometry (DXA)).All measures increased in supine position:...
The 2014 Varsity Medical Ethics debate convened upon the motion: "This house believes that genetic information should not be commoditised". This annual between students from Universities of Oxford and Cambridge, now in its sixth year, provided starting point for arguments on subject. present article brings together extends many put forward during debate. We explore circumstances under which material considered patentable, possible effects this research development novel therapeutics, need...
<b>Introduction:</b> We hypothesized that airway resistance differs in obese subjects with or without ventilatory failure <b>Methods:</b> 73 morbidly had measurements of both airways and adiposity <b>Results:</b> All measures increased the supine position: R5 (total resistance) by 37% (<i>p</i><0.0005), R20 (large 29% (<i>p</i><0.0005) R5-R20 (small 52% (<i>p</i><0.0005). . <b>Conclusion:</b> Our study identifies a considerable detrimental effect posture on tidal breathing subjects,...