A5019836672- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- S100 Proteins and Annexins
- Trauma and Emergency Care Studies
- Neurosurgical Procedures and Complications
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma Management and Diagnosis
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Fractures and Fixation Techniques
- Hip and Femur Fractures
- Ethics in medical practice
- Cerebrospinal fluid and hydrocephalus
- Ethics in Clinical Research
- Advanced Neuroimaging Techniques and Applications
- Craniofacial Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Healthcare cost, quality, practices
- Spinal Cord Injury Research
- Blood disorders and treatments
University of Cambridge
2020-2025
Turku University Hospital
2018-2025
Addenbrooke's Hospital
2020-2025
University of Turku
2015-2024
Karolinska Institutet
2023
Uppsala University
2023
Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) are promising biomarkers of traumatic brain injury (TBI).We investigated the relation GFAP UCH-L1 levels to severity TBI during first week after injury.Plasma were measured from 324 consecutive patients with acute 81 control subject enrolled in a 2-center prospective study. The baseline measures included initial Glasgow Coma Scale (GCS), head computed tomographic (CT) scan at admission, blood samples for...
Abstract Background Due to the lack of high-quality evidence which has hindered development evidence-based guidelines, there is a need provide general guidance on cranioplasty (CP) following traumatic brain injury (TBI), as well identify areas ongoing uncertainty via consensus-based approach. Methods The international consensus meeting post-traumatic CP was held during International Conference Recent Advances in Neurotraumatology (ICRAN), Naples, Italy, June 2018. This endorsed by...
<h3>Importance</h3> Trials often assess primary outcomes of traumatic brain injury at 6 months. Longer-term data are needed to for patients receiving surgical vs medical treatment intracranial hypertension. <h3>Objective</h3> To evaluate 24-month with hypertension treated decompressive craniectomy or standard care. <h3>Design, Setting, and Participants</h3> Prespecified secondary analysis the Randomized Evaluation Surgery With Craniectomy Uncontrollable Elevation Intracranial Pressure...
Abstract Background The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data available to provide optimal care in this scenario and worldwide variability clinical practice has been documented recent studies. Methods A multidisciplinary consensus panel physicians selected for their established scientific expertise the acute tSCI different specializations was established. World Society Emergency Surgery (WSES) European Association...
Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) have been studied as potential biomarkers of mild traumatic brain injury (mTBI). We report the levels GFAP UCH-L1 in patients with acute orthopedic injuries without central nervous system involvement, relate them to type extracranial injury, head magnetic resonance imaging (MRI) findings, CT-negative mTBI. Serum were longitudinally measured from 73 on arrival days 1, 2, 3, 7 after admission, follow-up visit...
The aim of the study was to examine ability eight protein biomarkers and their combinations in discriminating computed tomography (CT)-negative CT-positive patients with traumatic brain injury (TBI), utilizing highly sensitive immunoassays a well-characterized cohort. Blood samples were obtained from 160 acute TBI within 24 h admission. Levels β-amyloid isoforms 1-40 (Aβ40) 1-42 (Aβ42), glial fibrillary acidic (GFAP), heart fatty-acid binding (H-FABP), interleukin 10 (IL-10), neurofilament...
The purpose of this study was to correlate the early levels glial fibrillary acidic protein (GFAP) and neurofilament light (NF-L) with outcome in patients mild traumatic brain injury (mTBI). A total 107 mTBI (Glasgow Coma Scale ≥13) who had blood samples for GFAP NF-L available within 24 h arrival were included. Patients divided into computed tomography (CT)-positive CT-negative groups. Glasgow Outcome Scale-Extended (GOSE) used assess outcome. Outcomes defined as complete (GOSE 8) versus...
Blood biomarkers have been studied to improve the clinical assessment and prognostication of patients with moderate-severe traumatic brain injury (mo/sTBI). To assess their usability, one needs know potential factors that might cause outlier values affect decision making. In a prospective study, we recruited mo/sTBI (
Background: Patients with traumatic brain injury (TBI) exhibit a variable and unpredictable outcome. The proteins interleukin 10 (IL-10) heart fatty acid-binding protein (H-FABP) have shown predictive values for the presence of intracranial lesions. Aim: To evaluate individual combined outcome prediction ability IL-10 H-FABP, to compare them more studied S100β, glial fibrillary acidic (GFAP), neurofilament light (NF-L), both without clinical predictors. Methods: Blood samples from patients...
Abstract Background It is known that blood levels of neurofilament light (NF-L) and diffusion-weighted magnetic resonance imaging (DW-MRI) are both associated with outcome patients mild traumatic brain injury (mTBI). Here, we sought to examine the association between admission plasma NF-L white matter (WM) integrity in post-acute stage DW-MRI mTBI. Methods Ninety-three mTBI (GCS ≥ 13), sample for within 24 h admission, 90 days post-injury (median = 229) were included. Mean fractional...
There is substantial interest in blood biomarkers as fast and objective diagnostic tools for traumatic brain injury (TBI) the acute setting.Adult patients (≥18) with TBI of any severity indications CT scanning orthopaedic controls were prospectively recruited during 2011-2013 at Turku University Hospital, Finland. The was classified GCS: GCS 13-15 mild (mTBI); 9-12 moderate (moTBI) 3-8 severe (sTBI). Serum samples collected within 24 hours admission biomarker levels analysed high-performance...
Background: The purpose of this study was to investigate if admission levels total tau (T-tau) and β-amyloid isoforms 1-40 (Aβ40) 1-42 (Aβ42) could predict clinical outcome in patients with mild traumatic brain injury (mTBI). Methods: A 105 mTBI [Glasgow Coma Scale (GCS) ≥ 13] recruited Turku University Hospital, Turku, Finland were included study. Blood samples drawn within 24 h for analysis plasma T-tau, Aβ40, Aβ42. Patients divided into computed tomography (CT)-positive CT-negative...
One of the major goals neurointensive care is to prevent secondary injuries following aSAH. Bed rest and patient immobilization are practiced in order decrease risk DCI.To explore current practices place concerning management patients with aSAH, specifically, protocols habits regarding restrictions mobilization HOB positioning.A survey was designed, modified, approved by panel Trauma & Critical Care section EANS cover practice positioning aSAH.Twenty-nine physicians from 17 countries...
Background: Blood biomarkers may enhance outcome prediction performance of head computed tomography scores in traumatic brain injury (TBI). Objective: To investigate whether admission levels eight different protein can improve the Helsinki score (HCTS) without clinical covariates TBI. Materials and methods: Eighty-two patients with positive TBIs were included this study. Plasma β-amyloid isoforms 1-40 (Aβ40) 1-42 (Aβ42), glial fibrillary acidic protein, heart fatty acid-binding interleukin...
Neurofilament light (NF-L) is an axonal protein that has shown promise as a traumatic brain injury (TBI) biomarker. Serum NF-L shows rather slow rise after injury, peaking 1-2 weeks, although some studies suggest it may remain elevated for months TBI. The aim of this study was to examine if plasma levels several the correlate with functional outcome in patients who have sustained TBIs variable initial severity. In prospective 178 TBI and 40 orthopedic controls, we measured blood samples...
<title>Abstract</title> <bold>Background</bold> Cortical contusions are common in moderate-severe traumatic brain injury (TBI). often expand, potentially causing neuro-worsening several hours to days post-trauma. While contusion expansion (CE) may affect outcome, potential clinical and radiological markers that can predict CE have been insufficiently explored. In the present single-center retrospective observational cohort study, we evaluated outcome by Glasgow Outcome Scale extended (GOSE)...