A5030999846- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Sepsis Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Social Media and Politics
- Neuroinflammation and Neurodegeneration Mechanisms
- Education, Sociology, Communication Studies
- Metabolomics and Mass Spectrometry Studies
- Social and Educational Sciences
- Mechanisms of cancer metastasis
- COVID-19 and Mental Health
- Advanced Proteomics Techniques and Applications
- Trauma and Emergency Care Studies
- Mass Spectrometry Techniques and Applications
- Redox biology and oxidative stress
- Brain Metastases and Treatment
- Cardiac Arrest and Resuscitation
- Media, Religion, Digital Communication
University of Geneva
2017-2021
The aim of the study was to examine ability eight protein biomarkers and their combinations in discriminating computed tomography (CT)-negative CT-positive patients with traumatic brain injury (TBI), utilizing highly sensitive immunoassays a well-characterized cohort. Blood samples were obtained from 160 acute TBI within 24 h admission. Levels β-amyloid isoforms 1-40 (Aβ40) 1-42 (Aβ42), glial fibrillary acidic (GFAP), heart fatty-acid binding (H-FABP), interleukin 10 (IL-10), neurofilament...
The majority of patients with mild traumatic brain injury (mTBI) will have normal Glasgow coma scale (GCS) 15. Furthermore, only 5%-8% them be CT-positive for an mTBI. Having a useful biomarker would help clinicians evaluate patient's risk developing intracranial lesions. S100B protein is currently the most studied and promising this purpose. Heart fatty-acid binding (H-FABP) has been highlighted in models investigated as stroke severe TBI, example. Here, we performances H-FABP...
The purpose of this study was to correlate the early levels glial fibrillary acidic protein (GFAP) and neurofilament light (NF-L) with outcome in patients mild traumatic brain injury (mTBI). A total 107 mTBI (Glasgow Coma Scale ≥13) who had blood samples for GFAP NF-L available within 24 h arrival were included. Patients divided into computed tomography (CT)-positive CT-negative groups. Glasgow Outcome Scale-Extended (GOSE) used assess outcome. Outcomes defined as complete (GOSE 8) versus...
Inflammation is known to worsen cerebral damage at the acute phase of stroke. In this setting, cell adhesion molecules (CAMs) play a crucial role mediating migration immune cells into infarcted area. However, their value in long-term outcome prediction for patients with cerebrovascular diseases (CVD) less described.Levels four CAMs (E-selectin, P-selectin glycoprotein ligand-1, intercellular molecule-1, and vascular molecule-1 (VCAM-1)) six other biomarkers (C-reactive protein (CRP),...
Mild traumatic brain injury (mTBI) patients may have trauma-induced lesions detectable using CT scans. However, most will be CT-negative. There is thus a need for an additional tool to detect at risk. Single blood biomarkers, such as S100B and GFAP, been widely studied in mTBI patients, but date, none seems perform well enough. In many different diseases, combining several biomarkers into panels has become increasingly interesting diagnoses enhance classification performance. The present...
Traumatic brain injury is a common event where 70%–90% will be classified as mild TBI (mTBI). Among these, only 10% have lesion visible via CT scan. A triage biomarker would help clinicians to identify patients with mTBI who are at risk of developing and require The cells damaged by the shearing, tearing stretching set off inflammation cascades. These cause altered concentrations high number both pro-inflammatory anti-inflammatory proteins. This study aimed discover novel diagnostic...
Abstract Accurately determining time-of-onset of cerebral infarction is important to clearly identify patients who could benefit from reperfusion therapies. We assessed the kinetics peroxiredoxin 1 (PRDX1), a protein involved in oxidative stress during acute phase ischemia, and its ability determine stroke onset population with known less than 24 hours control group. Median PRDX1 levels were significantly higher compared controls. also blood samples withdrawn before vs. after 3 following...
Background: Patients with traumatic brain injury (TBI) exhibit a variable and unpredictable outcome. The proteins interleukin 10 (IL-10) heart fatty acid-binding protein (H-FABP) have shown predictive values for the presence of intracranial lesions. Aim: To evaluate individual combined outcome prediction ability IL-10 H-FABP, to compare them more studied S100β, glial fibrillary acidic (GFAP), neurofilament light (NF-L), both without clinical predictors. Methods: Blood samples from patients...
There is substantial interest in blood biomarkers as fast and objective diagnostic tools for traumatic brain injury (TBI) the acute setting.Adult patients (≥18) with TBI of any severity indications CT scanning orthopaedic controls were prospectively recruited during 2011-2013 at Turku University Hospital, Finland. The was classified GCS: GCS 13-15 mild (mTBI); 9-12 moderate (moTBI) 3-8 severe (sTBI). Serum samples collected within 24 hours admission biomarker levels analysed high-performance...
Background: Blood biomarkers may enhance outcome prediction performance of head computed tomography scores in traumatic brain injury (TBI). Objective: To investigate whether admission levels eight different protein can improve the Helsinki score (HCTS) without clinical covariates TBI. Materials and methods: Eighty-two patients with positive TBIs were included this study. Plasma β-amyloid isoforms 1-40 (Aβ40) 1-42 (Aβ42), glial fibrillary acidic protein, heart fatty acid-binding interleukin...
Aims: Computer tomography scan (CT) is used for the detection of cerebral lesions after mild traumatic brain injury (mTBI, Glasgow Coma Score 13-15). However, CT scans are expensive associated with radiation and may not detect such as diffuse axonal injury. Despite several years research on blood biomarkers, no alternative to yet available. The most promising biomarker remains S100b specificity around 30% sensitivity close 100%. In models, proteins GSTP1 (GSTP1 glutathione S-transferase pi...