A5055836529- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- S100 Proteins and Annexins
- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Immune cells in cancer
- Anesthesia and Neurotoxicity Research
- Bone and Joint Diseases
- Spinal Dysraphism and Malformations
- MRI in cancer diagnosis
- Head and Neck Surgical Oncology
- Pediatric Urology and Nephrology Studies
- Advanced Proteomics Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects and Toxicity Studies
Linköping University
2018-2024
Linköping University Hospital
2018-2023
Region Östergötland
2019
Uppsala University
2011-2013
Uppsala University Hospital
2010
OBJECTIVE Diffusion tensor imaging (DTI) along the perivascular space (ALPS) (DTI-ALPS)—by calculating ALPS index, a ratio accentuating water diffusion in space—has been proposed as noninvasive, indirect MRI method for assessing glymphatic function. The main aim of this study was to investigate whether DTI-ALPS would reveal dysfunction idiopathic normal pressure hydrocephalus (iNPH) and index associated with disease severity. METHODS Thirty iNPH patients (13 men; median age 77 years) 27...
Tsitsopoulos PP, Tobieson L, Enblad P, Marklund N. Clinical outcome following surgical treatment for bilateral cerebellar infarction.Acta Neurol Scand: 2011: 123: 345–351.© 2010 John Wiley & Sons A/S. Objectives – To analyze the initial clinical and radiological findings, treatment, decompression in patients with space-occupying infarction. Materials Methods Ten expansive infarction decreased level of consciousness were operated suboccipital craniectomy, removal infarcted tissue, placement...
The authors aimed to develop the first clinical grading scale for patients with surgically treated spontaneous supratentorial intracerebral hemorrhage (ICH).
One of the major goals neurointensive care is to prevent secondary injuries following aSAH. Bed rest and patient immobilization are practiced in order decrease risk DCI.To explore current practices place concerning management patients with aSAH, specifically, protocols habits regarding restrictions mobilization HOB positioning.A survey was designed, modified, approved by panel Trauma & Critical Care section EANS cover practice positioning aSAH.Twenty-nine physicians from 17 countries...
Abstract BACKGROUND We hypothesized that reduced cerebral blood flow (CBF) and/or energy metabolic disturbances exist in the tissue surrounding a surgically evacuated intracerebral hemorrhage (ICH). If present, such CBF impairments may contribute to ongoing injury and modest clinical efficacy of ICH surgery. OBJECTIVE To conduct an observational study state perihemorrhagic zone (PHZ) seemingly normal cortex (SNX) by microdialysis (MD) following surgical evacuation. METHODS evaluated 12...
Abstract The secondary injury cascades exacerbating the initial brain following intracerebral haemorrhage (ICH) are incompletely understood. We used dual microdialysis (MD) catheters placed in perihaemorrhagic zone (PHZ) and seemingly normal cortex (SNX) at time of surgical ICH evacuation ten patients (range 26–70 years). Routine interstitial MD markers (including glucose lactate/pyruvate ratio) were analysed remaining microdialysate was by two-dimensional gel electrophoresis (2-DE)...
Cerebral microdialysis (CMD) is a minimally invasive technique for sampling the interstitial fluid in human brain tissue. CMD allows monitoring metabolic state of tissue, as well macromolecules such proteins and peptides. Recovery or peptides can be hampered by their adsorption to membrane has been previously shown in-vitro, however, protein membranes not characterized following implantation tissue.In this paper, we describe pattern adsorbed compared that microdialysate cerebrospinal (CSF)....
Cranioplasty (CP) after decompressive craniectomy (DC) is a common neurosurgical procedure. Implementation of European Union (EU) directives recommending bacterial cultures before cryopreservation, lead to increased number autologous bone flaps being discarded due positive cultures. A new method for handling prior including the use pulsed lavage, was developed. The aim evaluate effect on proportion and surgical site infection (SSI) following CP surgery. Sixty-one from 53 consecutive DC...
To investigate long-term survival, neurologic outcome, and quality of life in patients with spontaneous supratentorial intracerebral hemorrhage (ICH) treated craniotomy hematoma evacuation. A nationwide multicenter retrospective analysis 341 who underwent evacuation ICH between January 1, 2011, December 31, 2015, was performed. Baseline characteristics associated 6-month mortality were investigated. Survivors received a questionnaire about their state health from which EuroQol 5D (EQ-5D)...
Supratentorial intracerebral haemorrhage (ICH) carries an excessive mortality and morbidity. Although surgical ICH treatment can be life-saving, the indications for surgery in larger cohorts of patients are controversial not well defined. We hypothesised that vary substantially among neurosurgical centres Sweden. In this nation-wide retrospective observational study, differences strategies all departments Sweden were evaluated. Patient records, neuroimaging clinical outcome focused on 30-day...
Abstract Spontaneous intracerebral hemorrhage (ICH) is the most devastating form of stroke. To refine treatments, improved understanding secondary injury processes needed. We compared energy metabolic, amyloid and neuroaxonal biomarkers in extracellular fluid (ECF) from perihemorrhagic zone (PHZ) non-injured (NCX) brain tissue, cerebrospinal (CSF) plasma. Patients (n = 11; age 61 ± 10 years) undergoing ICH surgery received two microdialysis (MD) catheters, one PHZ, NCX. ECF was analysed at...
Abstract Background Treatment options for spontaneous intracerebral hemorrhage (ICH) are limited. A possible inflammatory response in the brain tissue surrounding an ICH may exacerbate initial injury and could be a target treatment of subsequent secondary injury. The study objective was to compare levels mediators interstitial fluid perihemorrhagic zone (PHZ) seemingly normal cortex (SNX) acute phase after surgical evacuation ICH, with hypothesis being that difference demonstrated between...
Introduction Endoscopic third ventriculostomy (ETV) is becoming an increasingly widespread treatment for hydrocephalus, but research primarily based on paediatric populations. In 2009, Kulkarni et al created the ETV Success score to predict outcome of in children. The purpose this study create a prognostic model success adult patients with hydrocephalus. ability who will benefit from allow better primary patient selection both and shunting. This would reduce additional second procedures due...
Abstract BACKGROUND Traumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the mortality rates might have improved. OBJECTIVE To evaluate postoperative (30-d) younger vs (≥70 yr) patients ASDH. Comparing patients, secondary objectives patterns care 6 mo outcome according to Glasgow scale (GOS). Finally, traumatic ASDH, we aim provide prognostic variables. METHODS This is a...
Introduction Cerebrovascular reactivity imaging (CVR) is a diagnostic method for assessment of alterations in cerebral blood flow response to controlled vascular stimulus. The principal utility the capacity evaluate cerebrovascular reserve, thereby elucidating autoregulatory functioning. In CVR, CO 2 gas challenge most prevalent method, which elicits by inspired concentrations. While several systems have been proposed literature, only limited number devised operate tandem with mechanical...
ABSTRACT Cerebrovascular Reactivity Imaging (CVR) is a diagnostic method for assessment of alterations in cerebral blood flow response to controlled vascular stimulus. The principal utility the capacity evaluate cerebrovascular reserve, thereby elucidating autoregulatory functioning. Over past decade, CVR has accumulated large interest, emerging as an expanding research field and application diverse spectrum patient populations. In CVR, CO 2 gas challenge most prevalent method, which elicits...
Abstract Background Recently, Gong et al. (Gong 2022) showed, in nine heathy subjects, that plasma clearance of high doses iohexol given as contrast enhanced computed tomography (CT) could be used for determination glomerular filtration rate (GFR). We utilized from angiographic or other CT to critical ill patients calculation GFR and compared these data with standard low dose determinations. Method Patients at intensive care units (ICUs) Southeast Sweden intended radiographic investigations...
Abstract Background: Cerebral microdialysis (CMD) is a minimally invasive technique for sampling the interstitial fluid in human brain tissue. CMD allows monitoring metabolic state of tissue, as well macromolecules such proteins and peptides. Recovery or peptides can be hampered by their adsorption to membrane has been previously shown in-vitro , however, protein membranes not characterized following implantation Methods: In this paper, we describe pattern adsorbed compared that...
Abstract Background: Cerebral microdialysis (CMD) is a minimally invasive technique for sampling the interstitial fluid in human brain tissue. CMD allows monitoring metabolic state of tissue, as well macromolecules such proteins and peptides. Recovery or peptides can be hampered by their adsorption to membrane has been previously shown in-vitro, however, protein membranes not characterized following implantation Methods: In this paper, we describe pattern adsorbed compared that...