A5080697841- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Cardiac Arrest and Resuscitation
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Spinal Fractures and Fixation Techniques
- Cerebrovascular and Carotid Artery Diseases
- Spine and Intervertebral Disc Pathology
- Moyamoya disease diagnosis and treatment
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- EEG and Brain-Computer Interfaces
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Healthcare Systems and Technology
- Intraoperative Neuromonitoring and Anesthetic Effects
- Spinal Hematomas and Complications
- Respiratory Support and Mechanisms
- Autopsy Techniques and Outcomes
- Aortic aneurysm repair treatments
King's College Hospital NHS Foundation Trust
2016-2025
King's College London
2009-2025
King's College Hospital
2013-2024
Ain Shams University
2023
University of Groningen
2022
University of Sussex
2021-2022
Hospital de Cruces
2020-2022
University Hospitals Sussex NHS Foundation Trust
2022
University Hospital Heidelberg
2021
Innsbruck Medical University
2020-2021
The term cortical spreading depolarization (CSD) describes a wave of mass neuronal associated with net influx cations and water. Clusters prolonged CSDs were measured time-locked to progressive ischaemic damage in human cortex. CSD induces tone alterations resistance vessels, causing either transient hyperperfusion (physiological haemodynamic response) healthy tissue; or hypoperfusion [inverse response = ischaemia (CSI)] tissue at risk for damage, which has so far only been shown...
Object. The effect of normobaric hyperoxia (fraction inspired O 2 [FIO ] concentration 100%) in the treatment patients with traumatic brain injury (TBI) remains controversial. aim this study was to investigate effects on five cerebral metabolic indices, which have putative prognostic significance following TBI humans. Methods. At two independent neurointensive care units, authors performed a prospective 52 severe who were treated for 24 hours 100% FIO , starting within 6 admission. Data...
<h3>Importance</h3> Trials often assess primary outcomes of traumatic brain injury at 6 months. Longer-term data are needed to for patients receiving surgical vs medical treatment intracranial hypertension. <h3>Objective</h3> To evaluate 24-month with hypertension treated decompressive craniectomy or standard care. <h3>Design, Setting, and Participants</h3> Prespecified secondary analysis the Randomized Evaluation Surgery With Craniectomy Uncontrollable Elevation Intracranial Pressure...
Background Flow-diverting stents have demonstrated great promise for the treatment of cerebral aneurysms; however, clinical experience with devices remains very preliminary. We present two cases spontaneous delayed complications—one fatal aneurysm rupture and one symptomatic increase in volume—following intradural aneurysms Pipeline Embolization Device (PED). Presentation/intervention Two patients unruptured, carotid artery underwent uneventful PED (eV3, Irvine, California, USA). One...
Mass lesions from traumatic brain injury (TBI) often require surgical evacuation as a life-saving measure and to improve outcomes, but optimal timing technique, including decompressive craniectomy, have not been fully defined. The authors compared neurosurgical approaches in the treatment of TBI at 2 academic medical centers document variations real-world practice evaluate efficacies different on postsurgical course long-term outcome.Patients 18 years age or older who required lesion...
Spreading depolarizations occur spontaneously and frequently in injured human brain. They propagate slowly through tissue often cycling around a local area of damage. Tissue recovery after an spreading depolarization requires greatly augmented energy utilisation to normalise ionic gradients from virtually complete loss membrane potential. In the brain, this is difficult because blood flow low unreactive. study, we use new variant microdialysis, continuous on-line observe effects on brain...
Abstract Introduction and objectives The novel severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic has had drastic effects on global healthcare with the UK amongst countries most severely impacted. aim of this study was to examine how COVID-19 challenged neurosurgical delivery care in a busy tertiary unit serving socio-economically diverse population. Methods A prospective single-centre cohort including all patients referred service or subspecialty multidisciplinary teams...
Glioblastoma (GB) is an aggressive type of tumour for which therapeutic options and biomarkers are limited. GB diagnosis mostly relies on symptomatic presentation the and, in turn, brain imaging invasive biopsy that can delay its diagnosis. Description easily accessible effective present biofluids would thus prove invaluable Extracellular vesicles (EVs) derived from both stromal cells essential to intercellular crosstalk bulk, circulating EVs have been described as a potential reservoir...
This paper focuses on a role for ATP neurotransmission and gliotransmission in the pathophysiology of epileptic seizures. along with gap junctions propagates glial calcium wave, which is an extraneuronal signalling pathway central nervous system. Recently astrocyte intercellular waves have been shown to underlie seizures, conventional antiepileptic drugs attenuate these waves. Blocking ATP-mediated gliotransmission, therefore, represents potential target drugs. Furthermore, while knowledge...
The increasing utilisation of decompressive craniectomy for traumatic brain injury and stroke has led to an increase in the number cranioplasties undertaken. Cranioplasty is also undertaken following excision tumours originating from or invading skull vault, removal bone flaps due post-operative infection, management rarer causes oedema and/or refractory intracranial hypertension. existing literature which mainly consists single-centre, retrospective studies, shows a significant variation...
Importance The optimal timing for fixation of extremity fractures after traumatic brain injury (TBI) remains controversial. Objective To investigate whether patients who underwent within 24 hours TBI experienced worse outcomes than those had the procedure or more TBI. Design, Setting, and Participants This cohort study used data from Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Patients 16 years older with internal met inclusion...
Intracranial aneurysms and aneurysmal subarachnoid hemorrhage may occur more frequently in sickle-cell disease (SCD), this could be related to the sickle genotype moyamoya syndrome seen SCD.Records from a total of 1002 patients with SCD attending 2 specialized adult hematologic services were retrospectively reviewed. We analyzed data cohort 767 1 clinic between 2002 2013 235 other who have had neurovascular imaging 2007 2014.We identified 4 an during 9063 patient-years. The highest incidence...
There are many questions that remain unanswered regarding outcomes following cranioplasty including the timing of craniectomy as well material used.To establish and evaluate 30-d for all cranial reconstruction procedures in United Kingdom (UK) Ireland through a prospective multicenter cohort study.Patients undergoing insertion or revision between June 1, 2019 November 30, 25 neurosurgical units were included. Data collected include demographics, date indication, date, outcome.In total, 313...
Introduction Unruptured intracranial aneurysms (UIA) are common in the adult population, but only a relatively small proportion will rupture. It is therefore essential to have accurate estimates of rupture risk target treatment towards those who stand benefit and avoid exposing patients risks unnecessary treatment. The best available UIA natural history data PHASES study. However, this has never been validated given known heterogeneity populations, methods biases constituent studies, there...
The recently introduced Pipeline Flex Embolization Device with Shield Technology (Pipeline Shield) is the third generation of flow-diverter devices. It has a new stent-surface modification, which reduces thrombogenicity. We aimed to evaluate clinical and radiographic (safety efficacy) outcomes Shield.The 30-day 1-year mortality morbidity rates 6- 18-month aneurysm occlusion for procedures performed between March 2016 January 2018 were analyzed. 3D-TOF-MRA was used follow-up.Forty-four...