Tomas Tamošuitis
A5060292036- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- S100 Proteins and Annexins
- Acute Ischemic Stroke Management
- Optical Imaging and Spectroscopy Techniques
- Emergency and Acute Care Studies
- Palliative Care and End-of-Life Issues
- Head and Neck Surgical Oncology
- Radiation Dose and Imaging
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- Thermal Regulation in Medicine
- Anesthesia and Pain Management
- Bacterial Infections and Vaccines
- Cerebral Venous Sinus Thrombosis
- Spinal Fractures and Fixation Techniques
- Hip and Femur Fractures
Lithuanian University of Health Sciences
2014-2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2021-2022
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
2014-2022
University of Groningen
2022
RWTH Aachen University
2022
Sheffield Teaching Hospitals NHS Foundation Trust
2022
KU Leuven
2022
Assistance Publique – Hôpitaux de Paris
2022
Innsbruck Medical University
2020-2021
Universität Innsbruck
2020-2021
CPPopt denotes a Cerebral Perfusion Pressure (CPP) value at which the Pressure-Reactivity index, reflecting global state of Autoregulation, is best preserved. has been investigated as potential dynamically individualised CPP target in traumatic brain injury patients admitted intensive care unit. The prospective bedside use concept requires ensured safety and reliability recommended targets based on automatically-generated CPPopt. We aimed to: Increase stability automated algorithm by...
A previous retrospective single-centre study suggested that the percentage of time spent with cerebral perfusion pressure (CPP) below individual lower limit reactivity (LLR) is associated mortality in traumatic brain injury (TBI) patients. We aim to validate this a large multicentre cohort.Recordings from 171 TBI patients high-resolution cohort CENTER-TBI were processed ICM+ software. derived LLR as trend CPP at level for which index (PRx) indicates impaired cerebrovascular low CPP. The...
Cerebral autoregulation, as measured using the pressure reactivity index (PRx), has been related to global patient outcome in adult patients with traumatic brain injury (TBI). To date, this documented without accounting for standard baseline admission characteristics and intracranial (ICP). We evaluated association, adjusting ICP, a multi-center, prospective cohort. derived PRx correlation between ICP mean arterial prospectively collected multi-center data from High-Resolution Intensive Care...
It has been postulated previously that individualized cerebral perfusion pressure (CPP) targets can be derived from cerebrovascular reactivity indices. Differences between real CPP and target (named generically optimal CPP) linked to global outcome in adult traumatic brain injury (TBI). Different vascular indices utilized the determination. The goal of this study is evaluate CPPopt parameters, three intracranial (ICP)–derived indices, determine which one superior for 6- 12-month prediction....
Decompressive craniectomy (DC) in traumatic brain injury (TBI) has been suggested to influence cerebrovascular reactivity. We aimed determine if the statistical properties of vascular reactivity metrics and slow-wave relationships were impacted after DC, as such information would allow us comment on whether monitoring remains reliable craniectomy. Using CENTER-TBI High Resolution Intensive Care Unit (ICU) Sub-Study cohort, we selected those secondary DC patients with high-frequency...
Treatment and prevention of elevated intracranial pressure (ICP) is crucial in patients with severe traumatic brain injury (TBI). Elevated ICP associated secondary injury, both intensity duration an episode hypertension, often referred to as "ICP dose," are worse outcomes. Prediction such harmful episodes dose could allow for a more proactive preventive management TBI, potential implications on patients' The goal this study was develop validate machine-learning (ML) model predict potentially...
Abstract Background Morphological analysis of intracranial pressure (ICP) pulse waveforms provides indirect information on cerebrospinal compliance, which might be reduced by space-occupying lesions but also hypertension and aging. This study investigates the impact age mean ICP shape amplitude waveform in traumatic brain injury (TBI). Additionally, it explores association between morphological parameters mortality after TBI. Methods recordings from 183 TBI patients (median age: 50 (30, 61)...
Pressure reactivity index (PRx) and brain tissue oxygen (PbtO
Abstract Background After traumatic brain injury (TBI), fever is frequent. Brain temperature (BT), which directly linked to body temperature, may influence physiology. Increased and/or BT cause secondary damage, with deleterious effects on intracranial pressure (ICP), cerebral perfusion (CPP), and outcome. Methods Collaborative European NeuroTrauma Effectiveness Research in Traumatic Injury (CENTER-TBI), a prospective multicenter longitudinal study TBI Europe Israel, includes high resolution...
OBJECTIVE Intracranial pressure (ICP) pulse waveform analysis may provide valuable information about cerebrospinal pressure-volume compensation in patients with traumatic brain injury (TBI). The authors applied spectral methods to analyze ICP waveforms terms of the amplitude (AMP), high frequency centroid (HFC), and higher harmonics (HHC) also used a morphological classification approach assess changes shape using index (PSI). METHODS included 184 from Collaborative European NeuroTrauma...
Importance The optimal timing for fixation of extremity fractures after traumatic brain injury (TBI) remains controversial. Objective To investigate whether patients who underwent within 24 hours TBI experienced worse outcomes than those had the procedure or more TBI. Design, Setting, and Participants This cohort study used data from Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Patients 16 years older with internal met inclusion...
Midline shift and mass lesions may occur with traumatic brain injury (TBI) are associated higher mortality morbidity. The shape of intracranial pressure (ICP) pulse waveform reflects the state cerebrospinal pressure-volume compensation which be disturbed by injury. We aimed to investigate link between ICP pathological computed tomography (CT) features.ICP recordings CT scans from 130 TBI patients CENTER-TBI high-resolution sub-study were analyzed retrospectively. shift, lesion volume,...
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal this study was to further explore these associations using prospective multi-center Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) high-resolution intensive care unit (HR ICU) data set. Using CENTER-TBI HR ICU sub-study cohort, we evaluated those...
Brain tissue oxygen (PbtO2) monitoring in traumatic brain injury (TBI) has demonstrated strong associations with global outcome. Additionally, PbtO2 signals have been used to derive indices thought be associated cerebrovascular reactivity TBI. However, their true relationship slow-wave vasogenic fluctuations cerebral autoregulation remains unclear. The goal of this study was investigate the between intracranial pressure (ICP), mean arterial (MAP) and over time. Using Collaborative European...
Failure of cerebral autoregulation has been linked to unfavorable outcome after traumatic brain injury (TBI). Preliminary evidence from a small, retrospective, single-center analysis suggests that autoregulatory dysfunction may be associated with lesion expansion, particularly for pericontusional edema. The goal this study was further explore these associations using prospective, multi-center data the Collaborative European Neurotrauma Effectiveness Research in TBI (CENTER-TBI) and...
BACKGROUND Coagulopathy (CP) is a modifiable factor linked with secondary brain damage and poor outcome of traumatic injury (TBI). A shift towards goal-directed coagulation management has been observed recently. We investigated whether rotational thromboelastometry (ROTEM) based could be successfully implemented in TBI patients improve outcomes. MATERIAL AND METHODS prospective, case-control study was performed. Adult isolated requiring craniotomy were included this study. All underwent...
Abstract Background Traumatic brain injury (TBI) is an extremely heterogeneous and complex pathology that requires the integration of different physiological measurements for optimal understanding clinical management patients. Information derived from intracranial pressure (ICP) monitoring can be coupled with information obtained heart rate (HR) to assess interplay between heart. The goal our study investigate events simultaneous increases in HR ICP their relationship patient mortality.....
Abstract Background Monitoring intracranial pressure (ICP) and cerebral perfusion (CPP) is crucial in the management of patient with severe traumatic brain injury (TBI). In several institutions ICP CPP are summarized hourly entered manually on bedside charts; these data have been used large observational interventional trials. However, may change rapidly frequently, so recorded medical charts might underestimate actual shifts. The aim this study was to evaluate accuracy manual annotation for...
The conjunctival microcirculation has potential as a window to cerebral perfusion due related blood supply, close anatomical proximity and easy accessibility for microcirculatory imaging technique, such sidestream dark field (SDF) imaging. Our study aims evaluate sublingual in brain dead patients compare it with healthy volunteers two diametrically opposed conditions: full stop versus normal arterial supply the brain. In prospective observational we analyzed using SDF after reaching systemic...
The role of extra-cranial injury burden and systemic response on cerebrovascular in traumatic brain (TBI) is poorly documented. This study preliminarily assesses the association between admission features reactivity. Using Collaborative European Neurotrauma Effectiveness Research TBI High-Resolution ICU (HR ICU) sub-study cohort, we evaluated those patients with both archived high-frequency digital intra-parenchymal intra-cranial pressure monitoring data a minimum 6 h duration, presence copy...
The study presents data on the anti-inflammatory effects of a combination sodium dichloroacetate and valproate (DCA–VPA) expression inflammation- immune response-related genes in T lymphocytes SARS-CoV-2 patients. aimed to assess DCA–VPA cytokine activity, chemokine-mediated signaling, neutrophil chemotaxis, lymphocyte T-cell regulation proliferation pathways. included 21 patients with infection pneumonia: 9 male mean age 68.44 ± 15.32 years 12 female 65.42 15.74 years. They were...
Background and objectives: Organ shortage is considered to be a major limitation for increasing transplantation rates. Brain-dead donors (DBDs) are an important source of organs, but up 50% potential DBDs might not identified. An active brain-dead donor search could potentially increase deceased pool. The aim this study was evaluate the effectiveness DBD identification program one year impact on organ pool in Lithuania‘s biggest medical institution. Materials Methods: coordinator service...
Fever may aggravate secondary brain injury after traumatic (TBI). The aim of this study was to identify episodes temperature increases through visual plot analysis and algorithm supported detection, describe associated patterns changes in on tissue oxygen tension (PbtO2). Data derive from the high-resolution cohort multicenter prospective Collaborative European NeuroTrauma Effectiveness Research TBI (CENTER-TBI) study. Temperature (≥0.5°C) were visually identified 33 patients within first 11...