A5012978123- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury Research
- Thermal Regulation in Medicine
- Acute Ischemic Stroke Management
- Heart Rate Variability and Autonomic Control
- Atomic and Subatomic Physics Research
- Cardiovascular Health and Disease Prevention
Addenbrooke's Hospital
2023-2025
University of Cambridge
2023-2025
Abstract Objective:
Craniospinal compliance refers to the ability maintain stable intracranial pressure (ICP) given changes in volume. Craniospinal can be calculated directly as change volume over (ΔV/ΔICP). Considering distinct spectral components of ICP signal, it is pertinent explore whether dependent on frequency at which calculated. 
Approach:
Data from 92 hydrocephalus patients who underwent computerized infusion studies was retrospectively analyzed. recorded...
BACKGROUND AND OBJECTIVES: The priority for measuring and optimizing physiological metrics in brain injury care remains to be determined. Calculating targeting optimal cerebral perfusion pressure (CPP opt ) is an emerging treatment paradigm, but its association with other parameters outcome uncertain. A previous analysis of 22 patients found that tissue oxygenation (P bt O 2 peaked when CPP values were near . This study sought validate those findings using a distinct, larger cohort. It also...
Abstract Background Morphological analysis of intracranial pressure (ICP) pulse waveforms provides indirect information on cerebrospinal compliance, which might be reduced by space-occupying lesions but also hypertension and aging. This study investigates the impact age mean ICP shape amplitude waveform in traumatic brain injury (TBI). Additionally, it explores association between morphological parameters mortality after TBI. Methods recordings from 183 TBI patients (median age: 50 (30, 61)...
Different paradigms for neurocritical care of traumatic brain injury (TBI) have emerged in conjunction with advanced neuromonitoring technologies and derived metrics. The priority optimizing these metrics is not currently clear. goal this study was to determine whether achieving cerebral perfusion pressure (CPPopt) also improves other like oxygenation blood flow.
<title>Abstract</title> Purpose The amplitude of the intracranial pressure pulse waveform (AMP) has been a focal point current research. A pulsatile component with distinct morphology is also present in cerebral blood flow velocity (CBFV) signal. While CBFV (AmpCBFV) used indices like pulsatility index, relationship between AmpCBFV and AMP not established. This study aimed to investigate this via novel linear moving-window correlation index (RAMP) nonlinear joint symbolic analysis (JSA)....
Abstract Intracranial pressure (ICP), cerebral blood flow and volume are affected by craniospinal elasticity cerebrospinal fluid dynamics, interacting in complex, nonlinear ways. Traumatic brain injury (TBI) may significantly alter this relationship. This retrospective study investigated the relationship between vascular parenchymal intracranial compartments analysing two amplitudes: velocity (AmpCBFV) ICP (AMP) during hypocapnia manoeuvre TBI patients. Twenty-nine patients hospitalised at...
Abstract Background Traumatic brain injury (TBI) can significantly disrupt autonomic nervous system (ANS) regulation, increasing the risk for secondary complications, hemodynamic instability, and adverse outcome. This retrospective study evaluated windowed time-lagged cross-correlation (WTLCC) matrices describing cerebral hemodynamics–ANS interactions to predict outcome, enabling identifying high-risk patients who may benefit from enhanced monitoring prevent complications. Methods The first...
Disturbance in cerebrospinal fluid (CSF) circulation may overlap with abnormality of cerebral blood flow (CBF) hydrocephalus. Transcranial Doppler (TCD) ultrasonography is a non-invasive technique able to assess CBF velocity (CBFv) dynamics response controlled rise ICP during CSF infusion tests.Which TCD-derived hemodynamic parameters change ICP, and which direction?Infusion tests combined TCD monitoring arterial pressure (ABP) were conducted 65 hydrocephalic patients. TCD-based variables:...