Arminas Ragauskas
A5053723088- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Glaucoma and retinal disorders
- Optical Imaging and Spectroscopy Techniques
- Sepsis Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Hemodynamic Monitoring and Therapy
- S100 Proteins and Annexins
- Ophthalmology and Eye Disorders
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Radiation Dose and Imaging
- Retinal Diseases and Treatments
- Healthcare Technology and Patient Monitoring
- Machine Learning in Healthcare
- Corneal surgery and disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Intensive Care Unit Cognitive Disorders
- Dementia and Cognitive Impairment Research
Kaunas University of Technology
2016-2025
Vilnius University
2015-2025
University Hospital of North Norway
2024
University of Groningen
2022
Medical University of Vienna
2022
Assistance Publique – Hôpitaux de Paris
2022
Sheffield Teaching Hospitals NHS Foundation Trust
2022
KU Leuven
2022
Radboud University Nijmegen
2020-2021
Radboud University Medical Center
2020-2021
CPPopt denotes a Cerebral Perfusion Pressure (CPP) value at which the Pressure-Reactivity index, reflecting global state of Autoregulation, is best preserved. has been investigated as potential dynamically individualised CPP target in traumatic brain injury patients admitted intensive care unit. The prospective bedside use concept requires ensured safety and reliability recommended targets based on automatically-generated CPPopt. We aimed to: Increase stability automated algorithm by...
A previous retrospective single-centre study suggested that the percentage of time spent with cerebral perfusion pressure (CPP) below individual lower limit reactivity (LLR) is associated mortality in traumatic brain injury (TBI) patients. We aim to validate this a large multicentre cohort.Recordings from 171 TBI patients high-resolution cohort CENTER-TBI were processed ICM+ software. derived LLR as trend CPP at level for which index (PRx) indicates impaired cerebrovascular low CPP. The...
To compare the diagnostic reliability of optic nerve sheath diameter (ONSD) ultrasonography with a transcranial Doppler (TCD)-based absolute intracranial pressure (ICP) value measurement method for detection elevated ICP in neurological patients. The ONSD has been only tested previously on neurosurgical patients.A prospective clinical study non-invasive estimation based correlation and an two-depth TCD technology recruited 108 Ninety-two these patients have enrolled final analysis 85 using...
Cerebral autoregulation, as measured using the pressure reactivity index (PRx), has been related to global patient outcome in adult patients with traumatic brain injury (TBI). To date, this documented without accounting for standard baseline admission characteristics and intracranial (ICP). We evaluated association, adjusting ICP, a multi-center, prospective cohort. derived PRx correlation between ICP mean arterial prospectively collected multi-center data from High-Resolution Intensive Care...
It has been postulated previously that individualized cerebral perfusion pressure (CPP) targets can be derived from cerebrovascular reactivity indices. Differences between real CPP and target (named generically optimal CPP) linked to global outcome in adult traumatic brain injury (TBI). Different vascular indices utilized the determination. The goal of this study is evaluate CPPopt parameters, three intracranial (ICP)–derived indices, determine which one superior for 6- 12-month prediction....
Purpose . To assess differences in translaminar pressure gradient (TPG) and neuroretinal rim area (NRA) patients with normal tension glaucoma (NTG), high (HTG), healthy controls. Methods 27 NTG, HTG, controls were included the prospective pilot study (each group consisted of 9 patients). Intraocular (IOP), intracranial (ICP), confocal laser scanning tomography assessed. TPG was calculated as difference IOP minus ICP. ICP measured using noninvasive two-depth transcranial Doppler device. The...
Decompressive craniectomy (DC) in traumatic brain injury (TBI) has been suggested to influence cerebrovascular reactivity. We aimed determine if the statistical properties of vascular reactivity metrics and slow-wave relationships were impacted after DC, as such information would allow us comment on whether monitoring remains reliable craniectomy. Using CENTER-TBI High Resolution Intensive Care Unit (ICU) Sub-Study cohort, we selected those secondary DC patients with high-frequency...
Treatment and prevention of elevated intracranial pressure (ICP) is crucial in patients with severe traumatic brain injury (TBI). Elevated ICP associated secondary injury, both intensity duration an episode hypertension, often referred to as "ICP dose," are worse outcomes. Prediction such harmful episodes dose could allow for a more proactive preventive management TBI, potential implications on patients' The goal this study was develop validate machine-learning (ML) model predict potentially...
Abstract Background Morphological analysis of intracranial pressure (ICP) pulse waveforms provides indirect information on cerebrospinal compliance, which might be reduced by space-occupying lesions but also hypertension and aging. This study investigates the impact age mean ICP shape amplitude waveform in traumatic brain injury (TBI). Additionally, it explores association between morphological parameters mortality after TBI. Methods recordings from 183 TBI patients (median age: 50 (30, 61)...
Background and Objectives: Normal-tension glaucoma (NTG) is a subtype of primary open-angle characterized by progressive optic nerve damage despite intraocular pressure (IOP) remaining within the normal range. The underlying pathophysiology NTG remains incompletely understood, its diagnosis often delayed due to lack definitive screening tool. This study aimed evaluate differences in intracranial pulse wave amplitude recorded from closed eyelids between patients control subjects using novel...
Pressure reactivity index (PRx) and brain tissue oxygen (PbtO
Abstract Background After traumatic brain injury (TBI), fever is frequent. Brain temperature (BT), which directly linked to body temperature, may influence physiology. Increased and/or BT cause secondary damage, with deleterious effects on intracranial pressure (ICP), cerebral perfusion (CPP), and outcome. Methods Collaborative European NeuroTrauma Effectiveness Research in Traumatic Injury (CENTER-TBI), a prospective multicenter longitudinal study TBI Europe Israel, includes high resolution...
OBJECTIVE Intracranial pressure (ICP) pulse waveform analysis may provide valuable information about cerebrospinal pressure-volume compensation in patients with traumatic brain injury (TBI). The authors applied spectral methods to analyze ICP waveforms terms of the amplitude (AMP), high frequency centroid (HFC), and higher harmonics (HHC) also used a morphological classification approach assess changes shape using index (PSI). METHODS included 184 from Collaborative European NeuroTrauma...
Identification of individual therapy targets is critical for traumatic brain injury (TBI) patients. Clinical outcomes depend on cerebrovascular autoregulation (CA) impairment. Here, we compare the effectiveness optimal cerebral perfusion pressure (CPPopt)-targeted in younger (<45 years age) and elderly (≥45 TBI Single-center multi-modal invasive arterial blood pressure(t), intracranial (ICP)(t), CPP(t), CPPopt(t) monitoring (n = 81) was performed. ICM+ software used continuous status...
Midline shift and mass lesions may occur with traumatic brain injury (TBI) are associated higher mortality morbidity. The shape of intracranial pressure (ICP) pulse waveform reflects the state cerebrospinal pressure-volume compensation which be disturbed by injury. We aimed to investigate link between ICP pathological computed tomography (CT) features.ICP recordings CT scans from 130 TBI patients CENTER-TBI high-resolution sub-study were analyzed retrospectively. shift, lesion volume,...
Importance The optimal timing for fixation of extremity fractures after traumatic brain injury (TBI) remains controversial. Objective To investigate whether patients who underwent within 24 hours TBI experienced worse outcomes than those had the procedure or more TBI. Design, Setting, and Participants This cohort study used data from Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Patients 16 years older with internal met inclusion...
OBJECTIVE The aim of this study was to evaluate the robustness and zero-drift an intracranial pressure sensor, Neurovent-P (Raumedic AG, Münchberg, Germany), when used in clinical environment. METHODS A prospective multicenter trial, conforming International Organization for Standardization 14155 Standard, conducted 6 European BrainIT centers between July 2005 December 2006. Ninety-nine catheters were used. observational, followed by a centralized sensor bench test after catheter removal....
Cerebrovascular autoregulation (CA) is an important hemodynamic mechanism that protects the brain against inappropriate fluctuations in cerebral blood flow face of changing perfusion pressure. Temporal CA failure associated with worse outcomes various acute neurological diseases. An integrative approach presently used according to existing paradigm for association series temporal impairments patients traumatic injury (TBI).To explore influence duration impairment events on severe TBI patient...
Postoperative cognitive dysfunction (POCD) occurs in approximately 33-83% of patients after cardiac surgery with cardiopulmonary bypass (CPB). Recent clinical data suggest that real-time, intraoperative monitoring patient-specific cerebrovascular autoregulation (CA) may help to prevent POCD by detecting individual critical limits for mean arterial pressure (MAP) outside which CA is impaired. Objectives the study were detect episodes impaired during CPB, and investigate association between...