Saulius Ročka
A5009636552- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Sepsis Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Optical Imaging and Spectroscopy Techniques
- Spinal Fractures and Fixation Techniques
- S100 Proteins and Annexins
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Radiation Dose and Imaging
- Molecular Biology Techniques and Applications
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Epilepsy research and treatment
- Vagus Nerve Stimulation Research
- RNA Research and Splicing
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebral Venous Sinus Thrombosis
- Advanced MRI Techniques and Applications
- Hip and Femur Fractures
- Cardiovascular Health and Disease Prevention
Kaunas University of Technology
2015-2025
Vilnius University
2016-2025
Vilnius University Hospital Santariskiu Klinikos
2016-2024
Klinikum Aschaffenburg
2024
University of Groningen
2022
Medical University of Vienna
2022
Assistance Publique – Hôpitaux de Paris
2022
Radboud University Nijmegen
2020-2021
Radboud University Medical Center
2020-2021
University Hospital Heidelberg
2021
<h3>Objective</h3> Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart. <h3>Methods</h3> Sixteen European centers retrospectively identified cohorts of children adults who underwent epilepsy the period 1997 to 1998 (n = 562) or 2012 2013 736). Data collected included patient (sex, age) disease (duration, localization...
CPPopt denotes a Cerebral Perfusion Pressure (CPP) value at which the Pressure-Reactivity index, reflecting global state of Autoregulation, is best preserved. has been investigated as potential dynamically individualised CPP target in traumatic brain injury patients admitted intensive care unit. The prospective bedside use concept requires ensured safety and reliability recommended targets based on automatically-generated CPPopt. We aimed to: Increase stability automated algorithm by...
A previous retrospective single-centre study suggested that the percentage of time spent with cerebral perfusion pressure (CPP) below individual lower limit reactivity (LLR) is associated mortality in traumatic brain injury (TBI) patients. We aim to validate this a large multicentre cohort.Recordings from 171 TBI patients high-resolution cohort CENTER-TBI were processed ICM+ software. derived LLR as trend CPP at level for which index (PRx) indicates impaired cerebrovascular low CPP. The...
Abstract Background Morphological analysis of intracranial pressure (ICP) pulse waveforms provides indirect information on cerebrospinal compliance, which might be reduced by space-occupying lesions but also hypertension and aging. This study investigates the impact age mean ICP shape amplitude waveform in traumatic brain injury (TBI). Additionally, it explores association between morphological parameters mortality after TBI. Methods recordings from 183 TBI patients (median age: 50 (30, 61)...
Cerebral autoregulation, as measured using the pressure reactivity index (PRx), has been related to global patient outcome in adult patients with traumatic brain injury (TBI). To date, this documented without accounting for standard baseline admission characteristics and intracranial (ICP). We evaluated association, adjusting ICP, a multi-center, prospective cohort. derived PRx correlation between ICP mean arterial prospectively collected multi-center data from High-Resolution Intensive Care...
It has been postulated previously that individualized cerebral perfusion pressure (CPP) targets can be derived from cerebrovascular reactivity indices. Differences between real CPP and target (named generically optimal CPP) linked to global outcome in adult traumatic brain injury (TBI). Different vascular indices utilized the determination. The goal of this study is evaluate CPPopt parameters, three intracranial (ICP)–derived indices, determine which one superior for 6- 12-month prediction....
Decompressive craniectomy (DC) in traumatic brain injury (TBI) has been suggested to influence cerebrovascular reactivity. We aimed determine if the statistical properties of vascular reactivity metrics and slow-wave relationships were impacted after DC, as such information would allow us comment on whether monitoring remains reliable craniectomy. Using CENTER-TBI High Resolution Intensive Care Unit (ICU) Sub-Study cohort, we selected those secondary DC patients with high-frequency...
Treatment and prevention of elevated intracranial pressure (ICP) is crucial in patients with severe traumatic brain injury (TBI). Elevated ICP associated secondary injury, both intensity duration an episode hypertension, often referred to as "ICP dose," are worse outcomes. Prediction such harmful episodes dose could allow for a more proactive preventive management TBI, potential implications on patients' The goal this study was develop validate machine-learning (ML) model predict potentially...
The clinical significance of vertebral artery (VA) hypoplasia is under discussion. aim this retrospective study to evaluate a hypothesis possible causal link between VA (VAH) and the incidence posterior circulation stroke (PCS) or TIA depending on degree VAH vascular risk factors. A total 367 symptomatic (PCS TIA) 742 asymptomatic subjects, were selected participate in study. extracranial arteries examined by ultrasound. was defined as diameter entire course <3 mm, although different degrees...
Pressure reactivity index (PRx) and brain tissue oxygen (PbtO
Abstract Background After traumatic brain injury (TBI), fever is frequent. Brain temperature (BT), which directly linked to body temperature, may influence physiology. Increased and/or BT cause secondary damage, with deleterious effects on intracranial pressure (ICP), cerebral perfusion (CPP), and outcome. Methods Collaborative European NeuroTrauma Effectiveness Research in Traumatic Injury (CENTER-TBI), a prospective multicenter longitudinal study TBI Europe Israel, includes high resolution...
OBJECTIVE Intracranial pressure (ICP) pulse waveform analysis may provide valuable information about cerebrospinal pressure-volume compensation in patients with traumatic brain injury (TBI). The authors applied spectral methods to analyze ICP waveforms terms of the amplitude (AMP), high frequency centroid (HFC), and higher harmonics (HHC) also used a morphological classification approach assess changes shape using index (PSI). METHODS included 184 from Collaborative European NeuroTrauma...
Glial cells are fundamental for the pathophysiology of all neurological disorders. Astrocytes, primary homeostatic central nervous system (CNS), exhibit species-specific characteristics, with human astrocytes specifically displaying unique structural and functional features. It is thus essential to investigate human-specific astrocytic responses neuropathology using human-relevant models. Varicose projection (VP) astrocytes, traditionally considered specific humans apes, were suggested...
Identification of individual therapy targets is critical for traumatic brain injury (TBI) patients. Clinical outcomes depend on cerebrovascular autoregulation (CA) impairment. Here, we compare the effectiveness optimal cerebral perfusion pressure (CPPopt)-targeted in younger (<45 years age) and elderly (≥45 TBI Single-center multi-modal invasive arterial blood pressure(t), intracranial (ICP)(t), CPP(t), CPPopt(t) monitoring (n = 81) was performed. ICM+ software used continuous status...
Importance The optimal timing for fixation of extremity fractures after traumatic brain injury (TBI) remains controversial. Objective To investigate whether patients who underwent within 24 hours TBI experienced worse outcomes than those had the procedure or more TBI. Design, Setting, and Participants This cohort study used data from Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Patients 16 years older with internal met inclusion...
Cerebrovascular autoregulation (CA) is an important hemodynamic mechanism that protects the brain against inappropriate fluctuations in cerebral blood flow face of changing perfusion pressure. Temporal CA failure associated with worse outcomes various acute neurological diseases. An integrative approach presently used according to existing paradigm for association series temporal impairments patients traumatic injury (TBI).To explore influence duration impairment events on severe TBI patient...
Midline shift and mass lesions may occur with traumatic brain injury (TBI) are associated higher mortality morbidity. The shape of intracranial pressure (ICP) pulse waveform reflects the state cerebrospinal pressure-volume compensation which be disturbed by injury. We aimed to investigate link between ICP pathological computed tomography (CT) features.ICP recordings CT scans from 130 TBI patients CENTER-TBI high-resolution sub-study were analyzed retrospectively. shift, lesion volume,...
Brain tissue oxygen (PbtO2) monitoring in traumatic brain injury (TBI) has demonstrated strong associations with global outcome. Additionally, PbtO2 signals have been used to derive indices thought be associated cerebrovascular reactivity TBI. However, their true relationship slow-wave vasogenic fluctuations cerebral autoregulation remains unclear. The goal of this study was investigate the between intracranial pressure (ICP), mean arterial (MAP) and over time. Using Collaborative European...
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal this study was to further explore these associations using prospective multi-center Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) high-resolution intensive care unit (HR ICU) data set. Using CENTER-TBI HR ICU sub-study cohort, we evaluated those...
The aim of this study was to explore the association cerebrovascular autoregulation (CA) and optimal cerebral perfusion pressure (CPP) managing conditions with outcome traumatic brain injury (TBI) patients including additional information about patients' age grade diffuse axonal (DAI).The CA monitoring 28 TBI performed by using ICM+ software (Cambridge, UK). status estimating reactivity indexes (PRx) CPP data were processed in order obtain on patient-specific treatment calculating CPP.There...
Failure of cerebral autoregulation has been linked to unfavorable outcome after traumatic brain injury (TBI). Preliminary evidence from a small, retrospective, single-center analysis suggests that autoregulatory dysfunction may be associated with lesion expansion, particularly for pericontusional edema. The goal this study was further explore these associations using prospective, multi-center data the Collaborative European Neurotrauma Effectiveness Research in TBI (CENTER-TBI) and...