A5075628883- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Glioma Diagnosis and Treatment
- Cervical and Thoracic Myelopathy
- Spinal Hematomas and Complications
- Cerebrospinal fluid and hydrocephalus
- Musculoskeletal pain and rehabilitation
- Vascular Malformations Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Head and Neck Surgical Oncology
- Case Reports on Hematomas
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Medical Imaging and Analysis
- Sarcoma Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Pelvic and Acetabular Injuries
- Neurosurgical Procedures and Complications
- Anesthesia and Pain Management
- Bone Tumor Diagnosis and Treatments
- Hip and Femur Fractures
- EEG and Brain-Computer Interfaces
- Ophthalmology and Eye Disorders
- Transcranial Magnetic Stimulation Studies
- Medical Imaging and Pathology Studies
King's College Hospital NHS Foundation Trust
2020-2025
King's College Hospital
2018-2024
King's College London
2020-2022
National Health Service
2021
King's College - North Carolina
2020
University Hospital Dubrava
2007-2018
Northwestern University
2015-2018
Lurie Children's Hospital
2015-2018
National Hospital for Neurology and Neurosurgery
2017
University College London
2017
Diabetic nephropathy is currently the most common cause of end-stage renal disease (ESRD) in western world. A mouse model for diabetic that encompasses salient features this kidney not available. Here, we report CD1 mice, contrast to inbred C57BL/6 and 129Sv strains, develop ESRD associated with prominent tubulointerstitial nephritis fibrosis within 3 months die because complications by 6-7 after a single injection streptozotocin. Histopathologic lesions observed these mice mimic human...
A prospective cohort study.To evaluate whether an annular closure device could be implanted safely to reduce same-level recurrent disk herniation, or attenuate height loss and improve the outcome after lumbar discectomy.Same-level loss, progressive degeneration are common complications sequelae discectomy. Techniques these consequences may outcomes.Forty-six consecutive patients undergoing discectomy for single-level herniated at 2 institutions were followed prospectively with clinical...
Cauda equina syndrome (CES) results from nerve root compression in the lumbosacral spine, usually due to a prolapsed intervertebral disc. Evidence for management of CES is limited by its infrequent occurrence and lack standardised clinical definitions outcome measures. This prospective multi-centre observational cohort study adults with UK. We assessed presentation, investigation, management, all Core Outcome Set domains up one year post-operatively using clinician participant reporting....
Abstract Introduction and objectives The novel severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic has had drastic effects on global healthcare with the UK amongst countries most severely impacted. aim of this study was to examine how COVID-19 challenged neurosurgical delivery care in a busy tertiary unit serving socio-economically diverse population. Methods A prospective single-centre cohort including all patients referred service or subspecialty multidisciplinary teams...
OBJECTIVE Foot drop is characterized by weakness in ankle dorsiflexion, primarily due to failure of activation dorsiflexor muscles secondary neural compromise. The aim this study was evaluate surgical outcomes for unilateral painful foot lumbar disc herniation, specifically excluding cases with cauda equina syndrome. METHODS This retrospective spanned 7 centers, focusing on adult patients who underwent discectomies from September 2011 2022 (Medical Research Council [MRC] grade ≤ 3). Clinical...
Chiari I malformation has been a well-recognized clinical entity; however, its occurrence among infants and toddlers is unusual. Their presentations may be different from other age groups due to their lack of effective verbal communication. The authors analyze personal series patients focusing on symptomatology MRI characteristics. Treatment methods, results, outcome are analyzed in order identify appropriate surgical management with malformation. retrospectively reviewed 16 who were...
Cerebellopontine angle (CPA) and cerebellomedullary fissure (CMF) tumors are rare in children information is scarce the literature. This retrospective study reports their histological distribution tumor origin, describes surgical resections post-operative outcome based upon authors' consecutive personal series.Clinical data of infants 16 years old or younger age treated from 2001 to 2012 by a single surgeon was retrospectively reviewed. All had histologically verified CPA/CMF underwent...
Developing new clinical measures for degenerative cervical myelopathy (DCM) is an AO Spine RECODE-DCM Research, international and multi-stakeholder partnership, priority. Difficulties in detecting DCM its changes cause diagnostic treatment delays settings heightened costs trials due to elevated recruitment targets. Digital outcome can tackle these challenges their ability measure disease remotely, repeatedly, more economically.
<b>Objective</b> Same-level recurrent disc herniation is a well-defined complication following lumbar discectomy. Reherniation results in increased morbidity and health care costs. Techniques to reduce these consequences may improve outcomes cost after In prospective cohort study, we set out evaluate the associated with surgical management of recurrent, same-level primary <b>Methods</b> Forty-six consecutive European patients undergoing discectomy for single-level herniated at two...
Pilocytic astrocytomas (PAs) are the most common pediatric central nervous system neoplasms. In majority of cases these tumors benign and receive favorable prognosis following gross total surgical resection. patients with progressive or symptomatic tumors, aggressive resection is generally not feasible, thus radiation chemotherapy accepted initial adjuvant interventions. Due to serious long-lasting side-effects, limited in young children; therefore, widely practiced as an treatment for...
<b>Objective</b> To assess the potential benefits of disk reherniation reduction and height maintenance in limited diskectomy combined with implantation anular closure device. <b>Summary Background Data</b> Postoperative loss is apparent most patients undergoing lumbar for herniated nucleus pulposus. Less favorable patient outcomes are associated significant that can occur after aggressive tissue removal. More conservative removals, however, often burdened by increased risk recurrent...
Abstract BACKGROUND Type II odontoid fractures are a common cervical fracture in older people. Lower osseous-union rates reported those treated conservatively compared to surgically; however, the clinical relevance of nonunion is unknown. OBJECTIVE To compare pain, disability, and quality life people following conservative management type demonstrating nonunion. METHODS Electronic records were searched from 2008 2018 for adults ≥65 yr with fracture, managed semi-rigid collar. Clinical...
Primary diffuse meningeal melanomatosis can clinically mimic a wide variety of other conditions, including lymphoma, leukemia, neurosarcoidosis, metastatic carcinoma, acute disseminated encephalomyelitis, subacute meningitis, viral encephalitis, and idiopathic hypertrophic cranial pachymeningitis. We report on young patient with primary who presented papilledema, flaccid paraparesis, cognitive impairment. The importance imaging the whole central nervous system, cerebrospinal fluid analysis,...
<sec> <title>BACKGROUND</title> Developing new clinical measures for degenerative cervical myelopathy (DCM) is an AO Spine RECODE-DCM Research, international and multi-stakeholder partnership, priority. Difficulties in detecting DCM its changes cause diagnostic treatment delays settings heightened costs trials due to elevated recruitment targets. Digital outcome can tackle these challenges their ability measure disease remotely, repeatedly, more economically. </sec> <title>OBJECTIVE</title>...
Our aim was to investigate the effectiveness of navigated transcranial magnetic stimulation (nTMS) brain mapping characterise preoperative motor impairment caused by an intradural extramedullary (IDEM) tumour and postoperative cortical functional reorganisation. Preoperative 1-year follow-up clinical, radiological nTMS data from a case thoracic spinal meningioma that underwent surgical resection lesion were collected compared. A 67-year-old patient presented with severe progressive...
Case report.The nontraumatic cranial epidural hematoma is an extremely rare clinical entity and it commonly occurs in the presence of infectious diseases as complication sinusitis, coagulopathy, vascular malformation dura, hemorrhagic tumor, patients with sickle cell disease, systemic lupus erythematosus, after open heart surgery, on hemodialysis.We reported a case spontaneous that occurred herniated disc surgery. There was no history preceding head trauma patient medical unremarkable. To...