A5059561987- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Spinal Cord Injury Research
- Cervical and Thoracic Myelopathy
- Anesthesia and Pain Management
- Spondyloarthritis Studies and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Scoliosis diagnosis and treatment
- Surgical Simulation and Training
- Parkinson's Disease and Spinal Disorders
- Shoulder Injury and Treatment
- Trauma Management and Diagnosis
- Pelvic and Acetabular Injuries
- Social Media in Health Education
- Colorectal Cancer Surgical Treatments
- Botulinum Toxin and Related Neurological Disorders
- Meta-analysis and systematic reviews
- Cerebral Palsy and Movement Disorders
- Religion, Spirituality, and Psychology
- Hip and Femur Fractures
- Shoulder and Clavicle Injuries
- Trauma and Emergency Care Studies
- Prenatal Substance Exposure Effects
Mater Misericordiae University Hospital
2021-2024
St. Vincent's University Hospital
2022-2024
University College Dublin
2023-2024
Cappagh National Orthopaedic Hospital
2023-2024
Royal Victoria Hospital
2022-2023
University of Ulster
2022-2023
China Classification Society
2022
Royal Hospital for Children
2020
Cauda equina syndrome (CES) results from nerve root compression in the lumbosacral spine, usually due to a prolapsed intervertebral disc. Evidence for management of CES is limited by its infrequent occurrence and lack standardised clinical definitions outcome measures. This prospective multi-centre observational cohort study adults with UK. We assessed presentation, investigation, management, all Core Outcome Set domains up one year post-operatively using clinician participant reporting....
A significant hurdle for potential cell-based therapies is the subsequent survival and regenerative capacity of implanted cells. While many exciting developments have demonstrated promise preclinically, intervertebral disc (IVD) degeneration fail to translate equivalent clinical efficacy.This work aims ascertain relevance both a small large animal model by experimentally investigating comparing these models human from perspective anatomical scale their cellular metabolic potential.First,...
Cauda equina syndrome (CES) has significant medical, social, and legal consequences. Understanding the number of people presenting with CES their demographic features is essential for planning healthcare services to ensure timely appropriate management. We aimed establish incidence in a single country stratify by age, gender, socioeconomic status. As no consensus clinical definition exists, we compared using different diagnostic criteria.All patients radiological compression cauda due...
Ankylosing Spondylitis (AS) patients with acute spinal fractures represent a challenge for practicing spine surgeons due to difficult operative anatomy and susceptibility complications.
Abstract Background While growth factors have the potential to halt degeneration and decrease inflammation in animal models, literature investigating effect of dosage on human cells is lacking. Moreover, despite completion clinical trials using differentiation factor‐5 (GDF‐5), no results been publicly released. Aims The overall objective was quantitatively assess three clinically relevant concentrations GDF‐5 (0.25, 1, 2 mg) as a therapeutic for disc regeneration. Materials methods Firstly,...
Marland, Harry MB, BCh, BAO; Barve, Arnav McDonnell, Jake M. MRCSI; Wilson, Kielan V. MSc; Darwish, Stacey MD; Butler, Joseph S. PhD Author Information
Background: The elderly population have high rates of morbidity and mortality following traumatic spinal cord injuries (SCIs) but are also at increased risk intraoperative postoperative complications. This makes treatment decision-making less clear more challenging in this cohort compared to younger patients with similar injuries. Methods: A retrospective review was carried out our centre from 2016–2020 identify geriatric (≥65 years old) presenting a SCI, managed surgically. Cohorts were...
Background: Vertebral artery injuries (VAIs) can occur due to cervical trauma. VAI prove a serious complication and potentially compromise vascular supply the posterior aspect of brain. Currently, there is paucity evidence with regards incidence, management outcomes for these patients. The purpose this study investigate incidence associated trauma at our institution, their respective outcomes. Methods: A retrospective review was conducted national tertiary referral centre, from 2012–2021...
Background: An anterior cervical discectomy and fusion (ACDF) is commonly performed with cage plate constructs to provide stability the diseased or injured segment. Anchored stand-alone spacers represent a novel form of instrumentation conventional constructs. However, little known regarding their collective comparative evidence versus cages plates. The objective this study elucidate if anchored have improved operative characteristics postoperative outcomes in ACDF cohorts when compared...
Background: Lumbar disc disease can prove a debilitating injury. Typically, it is believed to be multifactorial process inclusive of aging, obesity and abnormal biomechanical loading patterns in the spine. Nevertheless, traditional theories pathophysiology may not hold true for younger populations. That serves premise this study, investigate comparative risk factors lumbar herniation (LDH) pre- post-menopausal female cohorts. Methods: A retrospective review was conducted at our institution,...