A5007184940- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Cerebrospinal fluid and hydrocephalus
- Anesthesia and Pain Management
- Spinal Dysraphism and Malformations
- Management of metastatic bone disease
- Scoliosis diagnosis and treatment
- Cervical and Thoracic Myelopathy
- Fetal and Pediatric Neurological Disorders
- Neurofibromatosis and Schwannoma Cases
- Pelvic and Acetabular Injuries
- S100 Proteins and Annexins
- Delphi Technique in Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve Injury and Rehabilitation
- Acute Ischemic Stroke Management
- Medical Imaging and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Anorectal Disease Treatments and Outcomes
- Neurosurgical Procedures and Complications
- Atherosclerosis and Cardiovascular Diseases
- Spinal Hematomas and Complications
- Electromagnetic Simulation and Numerical Methods
Walton Centre
2011-2024
University of Liverpool
2011-2024
Queen Elizabeth University Hospital
2022
Salford Royal Hospital
2007-2012
Royal Adelaide Hospital
2012
University of Manchester
2005-2012
<h3>Background</h3> The mechanism of development delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) is poorly understood. Inflammatory processes are implicated in the ischemic stroke and may also predispose to DCI following SAH. objective this study was test whether concentrations circulating inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6) interleukin 1 receptor antagonist (IL-1Ra)) were predictive for Secondary analyses considered white cell...
The proinflammatory cytokine interleukin (IL)-1 mediates several forms of experimentally induced acute brain injury and has been implicated in chronic neurodegenerative disorders. IL-1 receptor antagonist, IL-1RA, protects rodents against ischaemic injury, but its molecular mass (17 kDa) potentially limits the penetration peripherally administered IL-1RA. We therefore sought to identify whether therapeutically effective concentrations IL-1RA rat were also achieved patients with subarachnoid...
As many as 40% of shunts fail in the first year, mainly due to proximal obstruction. The role catheter position on failure rates has not been clearly demonstrated. authors conducted a prospective cohort study navigated shunt placement compared with standard blind at 3 European centers assess effect rates.All adult and pediatric patients undergoing de novo ventriculoperitoneal were included (patients slit ventricles excluded). underwent using anatomical landmarks. All subsequently adopted...
Endoscopic third ventriculostomy (ETV) is the treatment of choice for hydrocephalus, but outcome dependent on cause this disorder, and procedure remains principally preserve pediatric neurosurgeons. The role ETV in adult patients with hydrocephalus was therefore investigated.One hundred ninety underwent hydrocephalus. Cases were defined as primary (newly diagnosed, without a previously placed shunt) secondary (performed shunt malfunctions due to infection or mechanical blockage). Causes...
Study Design Retrospective study of a prospectively maintained database. Objective Our aim was to retrospectively review management and outcomes patients with low-grade hangman's fractures, specifically looking at differences in between collars halo immobilization. We also studied fracture patterns their treatment outcomes. Methods Forty-one fractures were identified from 105 axis 2007 2013. Typical defined as traumatic spondylolisthesis the causing bilateral pars interarticularis fracture....
The optimal invasive treatment for sciatica secondary to herniated lumbar disc remains controversial, with a paucity of evidence use non-surgical treatments such as transforaminal epidural steroid injection (TFESI) over surgical microdiscectomy. We aimed investigate the clinical and cost-effectiveness these options management radicular pain disc.We did pragmatic, multicentre, phase 3, open-label, randomised controlled trial at 11 spinal units across UK. Eligible patients were aged 16-65...
Cauda equina syndrome (CES) results from nerve root compression in the lumbosacral spine, usually due to a prolapsed intervertebral disc. Evidence for management of CES is limited by its infrequent occurrence and lack standardised clinical definitions outcome measures. This prospective multi-centre observational cohort study adults with UK. We assessed presentation, investigation, management, all Core Outcome Set domains up one year post-operatively using clinician participant reporting....
We analyzed retrospectively whether early surgery for cauda equina syndrome (CES) within 24, 48, or 72 hours of onset autonomic symptoms made any difference to bladder function at initial outpatient follow-up.CES potentially causes loss control including dysfunction, resulting in significant disability. There is debate regarding appropriate timing surgery.We conducted a retrospective cohort study 200 patients between 2000 and 2011 who underwent decompressive CES regional neurosurgical...
An improved understanding of Field Reversed Configuration (FRC) merging and stability in high acceleration compression magnetic fields is needed to speed up the development pulsed fusion concept developed at Helion Energy. All previous theoretical simulation work on FRC was performed using 2D MHD models. The results novel hybrid simulations (fluid electrons full-orbit kinetic ions) are presented. Results simulations, computed HYM code, compared analyzed. In cases without axial compression,...
Background. The optimal management of odontoid fractures in the elderly population is unclear and this group patients complicated by multiple co-morbidities. This study aimed to determine outcomes after conservative strategies were applied patient group. Methods. We carried out retrospective prospective analyses all with axial cervical spine injuries, at a single centre. included aged over 60 years type II III fractures. Information was gathered on demographics, ASA grading-associated...
Since surgical fusion of the spine was first described in 1911, multiple methods have been used to assess it. Although open exploration remains standard care for determination fusion, it is impractical most clinical situations. Static radiographs long as a practical method assessment, but they tend significantly overestimate presence solid fusion. Dynamic improve accuracy limitations include measurement reliability, disagreement on allowable motion, and two-dimensional nature radiographs....
What is already known about this subject? The naturally occurring interlukin-1 receptor antagonist (IL-1RA) markedly protects rodents against ischaemic, excitotoxic and traumatic brain injury, suggesting it may be of therapeutic value. When administered intravenously to patients soon after stroke, IL-1RA safe reduces the peripheral inflammatory response. However, a large protein (17 kDa), which limit penetration, thereby limiting its potential utility in injury. study adds. purpose these...
The aim of this study was to prospectively evaluate the use noninvasive electromagnetic neuronavigation in children, particular its complex hydrocephalus and slit ventricle syndrome.Prospective data collected from all pediatric patients undergoing insertion ventriculoperitoneal shunts using frameless January 2006 November 2007.Twenty-three fulfilled criteria. All ventricles were cannulated on first pass. There no immediate or early postprocedural complications. but 1 patient had resolution...
Object Image-guided neuroendoscopy is being increasingly used in an attempt to reduce the morbidity associated with surgery and make navigation easier. It has a particularly useful application pediatric population for treatment of conditions such as complex hydrocephalus arachnoid cysts. However, its use been limited by requirement rigid head fixation, which may be difficult infants because immaturity skull. In addition there can line-of-sight issues, problem optical-based systems....
Since surgical fusion of the spine was first described in 1911, multiple methods have been used to assess it. Although open exploration remains standard care for determination fusion, it is impractical most clinical situations. Static radiographs long as a practical method assessment, but they tend significantly overestimate presence solid fusion. Dynamic improve accuracy limitations include measurement reliability, disagreement on allowable motion, and two-dimensional nature radiographs....
Background Cauda Equina Syndrome (CES) is an emergency condition that requires acute intervention and can lead to permanent neurological deficit in working age adults. A Core Outcome Set (COS) the minimum set of outcomes should be reported by a research study within specific disease area. There significant heterogeneity outcome reporting for CES, which does not allow data synthesis between studies. The hypothesis COS CES developed future studies using patients healthcare professionals (HCPs)...
Aim: The choice between anterior cervical discectomy & fusion (ACD) or posterior foraminotomy (PCF) for the treatment of brachialgia is controversial. This study aimes to compare clinical outcomes these two operative inteventions brachialgia. Methods:Retrospective review prospectively collected data was performed. Patients receiving a primary ACD PCF treat brachialgia, in single tertiary neurosurgical unit were included. Surgical details, and patient reported (COMI-Neck questionnaire)...
The ultrasonic bone curette (Bone Scalpel) is a novel technique in neurosurgery for bony dissection. This study aimed to evaluate its use against conventional techniques primary lumbar decompression.This was retrospective cohort comparison, using Spine Tango Registry data. All patients undergoing procedure decompression secondary degenerative disease during 2-year period (2014-2016) were identified, split into age and gender matched cohorts utilising either scalpel or...
Sciatica is a common condition reported to affect over 3% of the UK population at any time and often caused by prolapsed intervertebral disc (PID). Although duration severity symptoms can vary, pain persisting beyond 6 weeks unlikely recover spontaneously may require investigation treatment. Currently, there no specific care pathway for sciatica in National Health Service (NHS), direct comparison exists between surgical microdiscectomy transforaminal epidural steroid injection (TFESI). The...
Cauda equina syndrome (CES) is a serious neurological condition most commonly due to compression of the lumbosacral nerve roots, which can result in significant disability. The evidence for acute intervention CES mainly from retrospective studies. There heterogeneity outcomes chosen analysis these studies, makes it difficult synthesise data across This study will develop core outcome set use future studies CES, engaging with key stakeholders and using transparent methodology. help ensure...