A5089800890- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Anesthesia and Pain Management
- Cervical and Thoracic Myelopathy
- Neurosurgical Procedures and Complications
- Nerve injury and regeneration
- Spinal Hematomas and Complications
- Nerve Injury and Rehabilitation
- Pelvic and Acetabular Injuries
- Management of metastatic bone disease
- Medical Imaging and Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Scoliosis diagnosis and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Delphi Technique in Research
- Clinical practice guidelines implementation
- Neurogenesis and neuroplasticity mechanisms
- Radiation Dose and Imaging
- Meta-analysis and systematic reviews
- Peripheral Nerve Disorders
- Anorectal Disease Treatments and Outcomes
- Statistical Methods in Clinical Trials
- Neurofibromatosis and Schwannoma Cases
- Pregnancy-related medical research
Walton Centre
2015-2024
University of Liverpool
2015-2024
University of Sheffield
2024
Chongqing Electromechanical Holdings (China)
2022
Accreditation Council for Graduate Medical Education
2022
Medical Education Institute
2022
American Nurses Credentialing Center
2022
Hanson Institute
2009
South Australia Pathology
2009
Royal Adelaide Hospital
2009
Study Design Retrospective study of a prospectively maintained database. Objective Our aim was to retrospectively review management and outcomes patients with low-grade hangman's fractures, specifically looking at differences in between collars halo immobilization. We also studied fracture patterns their treatment outcomes. Methods Forty-one fractures were identified from 105 axis 2007 2013. Typical defined as traumatic spondylolisthesis the causing bilateral pars interarticularis fracture....
The optimal invasive treatment for sciatica secondary to herniated lumbar disc remains controversial, with a paucity of evidence use non-surgical treatments such as transforaminal epidural steroid injection (TFESI) over surgical microdiscectomy. We aimed investigate the clinical and cost-effectiveness these options management radicular pain disc.We did pragmatic, multicentre, phase 3, open-label, randomised controlled trial at 11 spinal units across UK. Eligible patients were aged 16-65...
To assess the capacity of a retrovirus-engineered Schwann cell line (SCTM41), transfected with either glial line-derived neurotrophic factor (GDNF) construct or brain-derived (BDNF) construct, to sustain visual function in dystrophic Royal College Surgeons (RCS) rat.Cell suspensions were injected into subretinal space right eye 3-week-old RCS rats through transscleral approach. The left remained as an unoperated control. Sham-surgery animals received injections carrier medium plus DNase eye....
We analyzed retrospectively whether early surgery for cauda equina syndrome (CES) within 24, 48, or 72 hours of onset autonomic symptoms made any difference to bladder function at initial outpatient follow-up.CES potentially causes loss control including dysfunction, resulting in significant disability. There is debate regarding appropriate timing surgery.We conducted a retrospective cohort study 200 patients between 2000 and 2011 who underwent decompressive CES regional neurosurgical...
Objective. To present our experience with the Misonix Ultrasonic Bone scalpel in spinal surgery, highlighting its potential applications and advantages. Methods. Between March December 2011, a total of 937 cases were performed at single centre. The Scalpel (MBS) was used 62 these cases. Data collected prospectively using Spine Tango registry. Patient demographics, disease type, surgery complications all recorded along pre- post-operative core measures outcome index (COMI). Results. majority...
We have developed a novel Schwann cell line, SCTM41, derived from postnatal sciatic nerve cultures and stably transfected clone with rat glial line-derived neurotrophic factor (GDNF) construct. Coculture this GDNF-secreting enhances in vitro survival fiber growth of embryonic dopaminergic neurons. In the unilateral 6-OHDA lesion model Parkinson’s disease, we therefore made cografts these cells day 14 ventral mesencephalic grafts assayed for effects on process outgrowth. show that lines...
Background. The optimal management of odontoid fractures in the elderly population is unclear and this group patients complicated by multiple co-morbidities. This study aimed to determine outcomes after conservative strategies were applied patient group. Methods. We carried out retrospective prospective analyses all with axial cervical spine injuries, at a single centre. included aged over 60 years type II III fractures. Information was gathered on demographics, ASA grading-associated...
We aim to describe the outcomes after chronic subdural hematoma drainage (CSDH) management in a large cohort of patients on antithrombotic drugs, either antiplatelets or anticoagulants, at presentation and inform clinical decision making timing surgery recommencement these drugs. used data from previous UK-based multi-center, prospective study. Outcomes included recurrence within 60 days, functional outcome discharge, thromboembolic event during hospital stay. performed Cox regression...
Introduction Degenerative cervical myelopathy (DCM) is a common and disabling condition of symptomatic spinal cord compression secondary to degenerative changes in structures leading mechanical stress injury the cord. RECEDE-Myelopathy aims test disease-modulating activity phosphodiesterase 3/phosphodiesterase 4 inhibitor Ibudilast as an adjuvant surgical decompression DCM. Methods analysis multicentre, double-blind, randomised, placebo-controlled trial. Participants will be randomised...
The goal of this study was to prospectively assess outcome and cost for poor-grade subarachnoid hemorrhage patients presenting a regional neurosurgical center (Addenbrooke's Hospital, Cambridge, UK) between 1994 2001. Outcome measures were clinical at 6 months, number needed treat (NNT) favorable outcomes, analysis.Poor-grade (World Federation Neurological Surgeons grades 4 5) transferred the neurocritical care unit after intubation ventilation. After resuscitation drainage ventricular...
A clinicopathologic study of synovial cysts in the ligamentum flavum (LF) patients with spinal stenosis.To investigate pathogenesis lumbar juxtafacet cysts.Contradictions terminology applied to arise from frequent sparsity lining cells, which has led often being called "ganglion cysts" despite lacking confirmatory pathology.A total 27 consecutive radiologically confirmed stenosis underwent laminectomy. LF/facet joint (FJ) relationships were retained by en bloc excision LF and medial inferior...
Background Cauda Equina Syndrome (CES) is an emergency condition that requires acute intervention and can lead to permanent neurological deficit in working age adults. A Core Outcome Set (COS) the minimum set of outcomes should be reported by a research study within specific disease area. There significant heterogeneity outcome reporting for CES, which does not allow data synthesis between studies. The hypothesis COS CES developed future studies using patients healthcare professionals (HCPs)...
The last decade has witnessed a resurgence of interest in the surgical treatment metastatic spinal disease to compliment radiotherapy. A recent randomized controlled trial looking directly at this issue concluded strongly favour combination decompression and radiotherapy, there is now growing enthusiasm for surgery play role management these patients. We present prospective cohort study 62 patients who presented with cord or cauda equina compression, were treated fixation where necessary....
Study Design Case series and review of the literature. Objective To management giant calcified disks in our large cohort compare with existing We discuss surgical technique. Methods Twenty-nine cases herniated thoracic disk between 2000 2013 were reviewed. Eighteen patients identified as having disks, defined diffusely occupying at least 40% spinal canal. Demographic data was collected addition to presentation, imaging findings, operative details, outcomes using modified Japanese Orthopaedic...
Lumbar canal stenosis (LCS) is a common condition affecting elderly patients for which significant number undergo surgery. The validity and safety of simple laminectomy in this not fully understood. Furthermore, the presence pre-existing spondylolisthesis controversial with respect to need additional spinal stabilization. We prospectively studied consecutive cohort 100 clinical radiological LCS under care single surgeon. Outcome measures (SF-36, visual analogue scores back leg symptoms,...
Aim: The choice between anterior cervical discectomy & fusion (ACD) or posterior foraminotomy (PCF) for the treatment of brachialgia is controversial. This study aimes to compare clinical outcomes these two operative inteventions brachialgia. Methods:Retrospective review prospectively collected data was performed. Patients receiving a primary ACD PCF treat brachialgia, in single tertiary neurosurgical unit were included. Surgical details, and patient reported (COMI-Neck questionnaire)...
The ultrasonic bone curette (Bone Scalpel) is a novel technique in neurosurgery for bony dissection. This study aimed to evaluate its use against conventional techniques primary lumbar decompression.This was retrospective cohort comparison, using Spine Tango Registry data. All patients undergoing procedure decompression secondary degenerative disease during 2-year period (2014-2016) were identified, split into age and gender matched cohorts utilising either scalpel or...