A5017962441- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cerebrospinal fluid and hydrocephalus
- Transcranial Magnetic Stimulation Studies
- Intraoperative Neuromonitoring and Anesthetic Effects
- Spinal Hematomas and Complications
- Spinal Dysraphism and Malformations
- Vascular Malformations Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Musculoskeletal pain and rehabilitation
- Case Reports on Hematomas
- Surgical Simulation and Training
- Management of metastatic bone disease
- Neurological disorders and treatments
- Neurosurgical Procedures and Complications
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Hip and Femur Fractures
- Ethics in Clinical Research
- Neurofibromatosis and Schwannoma Cases
- Pituitary Gland Disorders and Treatments
- Anatomy and Medical Technology
- Brain Metastases and Treatment
King's College Hospital NHS Foundation Trust
2019-2025
Barking, Havering And Redbridge University Hospitals NHS Trust
2024-2025
Queen's Hospital
2024-2025
Queen's Hospital
2022-2025
North East London NHS Foundation Trust
2025
King's College Hospital
2019-2024
Queens Hospital Center
2024
Kings Health Partners
2020-2022
Addenbrooke's Hospital
2021
University of Cambridge
2021
Cauda equina syndrome (CES) results from nerve root compression in the lumbosacral spine, usually due to a prolapsed intervertebral disc. Evidence for management of CES is limited by its infrequent occurrence and lack standardised clinical definitions outcome measures. This prospective multi-centre observational cohort study adults with UK. We assessed presentation, investigation, management, all Core Outcome Set domains up one year post-operatively using clinician participant reporting....
5-Aminolevulic acid-guided surgery (5-ALA-GS) improves the extent of resection (EoR) and progression-free survival in patients with glioblastoma multiforme (GBM).A single-center retrospective cohort study adult GBM who had surgical between 2013 2019, 5-ALA guided versus a non-5-ALA cohort. The primary outcome was overall (OS). Secondary outcomes were EoR, performance status (PS), new focal neurological deficit.Three hundred forty-three included: 253 5-ALA-GS group 90 non-5-ALA-GS group. OS...
OBJECTIVE Foot drop is characterized by weakness in ankle dorsiflexion, primarily due to failure of activation dorsiflexor muscles secondary neural compromise. The aim this study was evaluate surgical outcomes for unilateral painful foot lumbar disc herniation, specifically excluding cases with cauda equina syndrome. METHODS This retrospective spanned 7 centers, focusing on adult patients who underwent discectomies from September 2011 2022 (Medical Research Council [MRC] grade ≤ 3). Clinical...
Penfield's motor homunculus describes a caricaturised yet useful representation of the map various body parts on pre-central cortex. We propose supplemental clinically represented areas human in cortex and novel subcortical corticospinal tract map. believe this knowledge is essential for safe surgery patients with eloquent brain lesions. A single-institution retrospective cohort study who underwent craniotomy lesions intraoperative neuromonitoring (cortical subcortical) between 2015 2020 was...
There are many questions that remain unanswered regarding outcomes following cranioplasty including the timing of craniectomy as well material used.To establish and evaluate 30-d for all cranial reconstruction procedures in United Kingdom (UK) Ireland through a prospective multicenter cohort study.Patients undergoing insertion or revision between June 1, 2019 November 30, 25 neurosurgical units were included. Data collected include demographics, date indication, date, outcome.In total, 313...
MGMT promoter methylation is related to the increased sensitivity of tumour tissue chemotherapy with temozolomide (TMZ) and thus improved patient survival. However, it unclear how extent affects outcomes. In our study, a single-centre retrospective we explore impact in patients glioblastoma who were operated upon 5-ALA. Demographic, clinical histology data, survival rates assessed. A total 69 formed study group (mean age 53.75 ± 15.51 years old). Positive 5-ALA fluorescence was noted 79.41%....
BACKGROUND: Navigated transcranial magnetic stimulation (nTMS) is a well-established preoperative mapping tool for motor-eloquent glioma surgery. Machine learning (ML) and nTMS may improve clinical outcome prediction histological correlation. METHODS: This was retrospective cohort study of patients who underwent surgery gliomas between 2018 2022. Ten healthy subjects were included. Preoperative nTMS-derived variables collected: resting motor threshold (RMT), interhemispheric RMT ratio...
Abstract BACKGROUND Type II odontoid fractures are a common cervical fracture in older people. Lower osseous-union rates reported those treated conservatively compared to surgically; however, the clinical relevance of nonunion is unknown. OBJECTIVE To compare pain, disability, and quality life people following conservative management type demonstrating nonunion. METHODS Electronic records were searched from 2008 2018 for adults ≥65 yr with fracture, managed semi-rigid collar. Clinical...
Brain tumour surgery in visual eloquent areas poses significant challenges to neurosurgeons and has reported inconsistent results. This is a single-centre prospective cohort study of patients admitted for asleep intra-axial lesions areas. Demographic clinical information, data from tractography evoked potentials (VEPs) monitoring were recorded correlated with outcomes. Thirty-nine included (20 females, 19 males; mean age 52.51 ± 14.08 years). Diffuse intrinsic glioma was noted 61.54%...
Objectives Chordomas are rare, slow-growing, and osteo-destructive tumors of the primitive notochord. There is still contention in literature as to optimal management chordoma. We conducted a systematic review surgical chordoma along with our 10-year institutional experience. Design A search was performed October 2020 by using MEDLINE EMBASE for articles relating clival chordomas. also searched all adult patients surgically treated primary chordomas at institute between 2009 2019....
Study Design Retrospective cohort study. Objectives Intraoperative neurophysiological monitoring (IONM) is widely used in spinal neurosurgery, particularly for intramedullary tumours. However, its validity intradural extramedullary (IDEM) tumours less clearly defined, this being the focus of Methods We compared outcomes patients that underwent resection IDEM with and without IONM between 2010 2020. Primary were postoperative American Spinal Injury Association (ASIA) scores. Other factors...
The growth characteristics of vestibular schwannomas (VSs) under surveillance can be studied using a Bayesian method risk stratification by time after onset, allowing dynamic evaluations risks. There is no consensus on the optimum strategy in terms frequency and duration, particularly for long-term In this study, conditional probability new VS was reported patients 5 years demonstrated nongrowth. This allowed modeling risks, creation an evidence-based protocol, proposal cost-benefit analysis...