A5018227253- Linguistic research and analysis
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Linguistic Education and Pedagogy
- Parkinson's Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Language and Culture
- Epilepsy research and treatment
- Meningioma and schwannoma management
- Linguistics, Language Diversity, and Identity
- Fetal and Pediatric Neurological Disorders
- Historical and Archaeological Studies
- Linguistics and language evolution
- Cerebrospinal fluid and hydrocephalus
- Lexicography and Language Studies
- Head and Neck Surgical Oncology
- Hemoglobinopathies and Related Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological diseases and metabolism
- Stroke Rehabilitation and Recovery
- European and International Law Studies
- Neurological Complications and Syndromes
University of Wrocław
2012-2023
King's College Hospital
2007-2022
King's College - North Carolina
2022
University of Opole
2020-2022
King's College Hospital NHS Foundation Trust
2010-2021
ORCID
2020
King's College London
2006-2017
Sorbonne Université
2017
South London and Maudsley NHS Foundation Trust
2017
Danderyds sjukhus
2015
Bilateral uterine artery embolisation was performed to treat eight women with symptomatic large fibroids requiring treatment. Uterine volume quantitatively assessed by magnetic resonance imaging. Both arteries were occluded effectively in all women, and the procedure well tolerated, a 24-36 hour admission for pain relief. The level of experienced variable, but controlled. Some intermittent vaginal discharge following procedure. Improvement symptoms occurred six seven eighth woman conceived....
<b>Objective: </b> To use diffusion tensor MRI to quantify and compare degeneration of the pons cerebellar peduncles in multiple system atrophy (MSA), progressive supranuclear palsy (PSP), Parkinson disease (PD) relate changes measures clinical features localized atrophy. <b>Methods: We used a region-of-interest approach measure fractional anisotropy mean diffusivity middle peduncles, decussation superior 17 patients with MSA, PSP, 12 PD, healthy volunteers. also evaluated on T2-weighted...
<b>Objective:</b> To determine whether it is worth pursuing surgery for the treatment of epilepsy in patients with normal neuroimaging. <b>Methods:</b> Two patient populations were studied: (1) 136 consecutive who surgically treated; (2) 105 assessed chronically implanted intracranial electrodes within same period. Sixty belonged to both groups, and included all 21 had <b>Results:</b> There no differences proportion favourable outcome between those abnormal neuroimaging, irrespective...
Although often clinically indistinguishable in the early stages, Parkinson's disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) have distinct neuropathological changes. The aim of current study was to identify white matter tract neurodegeneration characteristic each three syndromes. Tract-based spatial statistics (TBSS) used perform a whole-brain automated analysis diffusion tensor imaging (DTI) data compare differences fractional anisotropy (FA) mean...
In this study, we investigated whether diffusion tensor MRI (DTI) could detect progressive corticospinal tract degeneration in amyotrophic lateral sclerosis (ALS) and changes variables reflected clinical deterioration. Twenty‐three ALS patients 25 healthy volunteers underwent whole brain DTI. Patients a subset (n = 12) of controls returned for second scan. Clinical measures disease severity were assessed the group. Changes fractional anisotropy (FA) mean diffusivity (MD) measured along using...
Parkinson's disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) are neurodegenerative diseases that can be difficult to distinguish clinically. The objective of the current study was use surface-based analysis techniques assess cortical thickness, surface area grey matter volume identify unique morphological patterns atrophy in PD, MSA PSP relate these change duration clinical features.High resolution 3D T1-weighted MRI volumes were acquired from 14 PD...
<h3>Background:</h3> It has been suggested that impaired cerebral autoregulation and vasodilatory capacity may play in role the pathogenesis of leukoaraiosis seen small vessel disease. Adequate perfusion deep white matter brain depends on relationships between blood pressure (BP), vasoreactivity autoregulation. <h3>Methods:</h3> 24 h ambulatory BP measurement, quantitative volumetric MRI analysis lesion (WML) volume transcranial Doppler ultrasound assessments CO<sub>2</sub> reactivity...
Wake-up ischemic stroke (WUIS) patients are not eligible for thrombolysis; the a priori hypothesis was that thrombolysis of selected WUIS who meet clinical and imaging criteria treatment is associated with better outcomes.The sample consisted consecutive fulfilled predefined criteria: (1) were last seen normal >4.5 hours <12 before presentation; (2) National Institute Health Stroke Scale score ≥ 5; (3) No or early changes <1/3 middle cerebral artery territory on computed tomography imaging;...
Background and Purpose— Wake-up ischemic stroke (WUIS) patients are not thrombolysed even if they meet other criteria for treatment. We hypothesized that with WUIS showing no or early changes on brain imaging will have thrombolysis outcomes comparable those known time of symptom onset. Methods— Consecutive sampling a prospective registry between January 2009 December 2010 identified 394 meeting predefined inclusion criteria, 326 presenting within 0 to 4.5 hours onset (Reference Group) 68...
DCX mutations cause mental retardation in male subjects with lissencephalypachygyria and female subcortical band heterotopia (SBH). We observed four families which carrier women had normal brain magnetic resonance imaging (MRI) mild retardation, or without epilepsy. Affected SBH pachygyria-SBH. In two families, the phenotype was both genders. first family, we found a tyr138his mutation that is predicted to result abnormal folding small hinge region. second an arg178cys at initial portion of...
Sickle cell anemia is one of the commonest causes stroke in children. It usually, but not always, associated with intracranial vasculopathy. We have assessed value ultrasound screening for extracranial internal carotid artery disease.Using Doppler scanning, we peak systolic blood velocity, tortuosity and stenosis arteries 236 children sickle anemia. Seventeen had previously a stroke. All measurements were performed as part routine clinical care.The median velocity was 148cm/s (5(th) centile...
Penfield's motor homunculus describes a caricaturised yet useful representation of the map various body parts on pre-central cortex. We propose supplemental clinically represented areas human in cortex and novel subcortical corticospinal tract map. believe this knowledge is essential for safe surgery patients with eloquent brain lesions. A single-institution retrospective cohort study who underwent craniotomy lesions intraoperative neuromonitoring (cortical subcortical) between 2015 2020 was...
To determine the characteristics and clinical significance of focal slow activity its association with epileptogenesis in patients temporal lobe epilepsy (TLE).We analyzed interictal EEGs 141 who had resections for intractable seizures correlated findings pathologic changes outcome. The were categorized into medial sclerosis, tumors, nonspecific changes.Lateralized was found 66% patients, it mainly temporal, delta frequency irregular morphology. None characteristics, including quantity...
BackgroundThere is no consensus as to whether magnetic resonance imaging (MRI) should be used part of the initial clinical evaluation patients with first-episode psychosis (FEP).Aims(a) To assess logistical feasibility routine MRI; (b) define significance radiological abnormalities in FEP.MethodRadiological reports from MRI scans two FEP samples were reviewed; one comprised 108 and 98 healthy controls recruited a research study other 241 scanned at presentation plus 66 controls.ResultsIn...
Ethnic phenotypic differences in Parkinson's disease (PD) are important to understand the heterogeneity of PD and develop biomarkers clinical trials.To investigate (i) whether there non-motor symptoms (NMS)- comorbidity-based between Black, Asian Minority (BAME) White patients (ii) clinically available may help differentiate explain groups.This is a multicentre (four sites, London), real-life, cross-sectional study including BAME or ethnicity. The primary outcome was detailed NMS assessment;...
<h3>Aim</h3> To evaluate a standardised MRI acquisition protocol and new image rating scale for disease severity in patients with progressive supranuclear palsy (PSP) multiple systems atrophy (MSA) large multicentre study. <h3>Methods</h3> The consisted of two-dimensional sagittal axial T1, PD, coronal T2 weighted acquisitions. 32 item ordinal evaluated abnormalities within the basal ganglia posterior fossa, blind to diagnosis. Among 760 study population (PSP=362, MSA=398), 627 had per...
Abstract Background Duplex ultrasonography and magnetic resonance angiography (MRA) are becoming competitive alternatives to for determining the degree of internal carotid artery (ICA) stenosis. Varying reports have been published regarding suitability each technique grading ICA disease. This retrospective study compared merits these three modalities measuring Methods One hundred eleven patients being considered endarterectomy underwent intra-arterial digital subtraction (DSA) via arch...