A5077658624- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Neuroblastoma Research and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Bone and Joint Diseases
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Radiopharmaceutical Chemistry and Applications
- Radiation Dose and Imaging
- Parkinson's Disease Mechanisms and Treatments
- Advanced Radiotherapy Techniques
- Skin Diseases and Diabetes
- Renal function and acid-base balance
- Radiomics and Machine Learning in Medical Imaging
- Adrenal and Paraganglionic Tumors
- Urological Disorders and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Breast Cancer Treatment Studies
- Alcoholism and Thiamine Deficiency
- Pediatric Urology and Nephrology Studies
King's College Hospital
2013-2020
King's College - North Carolina
2019-2020
King's College Hospital NHS Foundation Trust
2016-2020
Laboratoire d’Imagerie Biomédicale
2014-2016
University of Groningen
2015
Mount Vernon Hospital
2011
Derriford Hospital
1993-2005
Fundación Juan March
2005
British Nuclear Medicine Society
2004-2005
Royal Cornwall Hospital Trust
1996-2000
<h3>Objective</h3> Impulse control disorders are commonly associated with dopaminergic therapy in Parkinson9s disease (PD). PD patients impulse demonstrate enhanced dopamine release to conditioned cues and a gambling task on [<sup>11</sup>C]raclopride positron emission tomography (PET) imaging ventral striatal activity reward functional MRI. We compared age-matched gender-matched controls without using [<sup>123</sup>I]FP-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane) single photon computed...
177Lu-DOTATATE peptide receptor radionuclide therapy is administered to patients on an inpatient and outpatient basis for the treatment of well-differentiated, metastatic neuroendocrine tumours. Following administration, these present external radiation hazard due gamma emissions lutetium-177. The purpose this study was determine precautions be observed by restrict dose received patients' family members less than 5 mSv in years public 1 per year line with current UK legislation....
The natural history of the diabetic foot is aggressive and complex. To counteract this, we describe transformation a Multidisciplinary Diabetic Foot Clinic into Day Unit, which delivers an emergency open access system for patients, with “one-stop,” same day service in investigations are performed, results reviewed treatment implemented. It also provides joint clinics vascular, orthopaedic, plastic surgeons specialized casting complex neuropathic feet administration intravenous or...
Ethnic phenotypic differences in Parkinson's disease (PD) are important to understand the heterogeneity of PD and develop biomarkers clinical trials.To investigate (i) whether there non-motor symptoms (NMS)- comorbidity-based between Black, Asian Minority (BAME) White patients (ii) clinically available may help differentiate explain groups.This is a multicentre (four sites, London), real-life, cross-sectional study including BAME or ethnicity. The primary outcome was detailed NMS assessment;...
Spinning top urethra (STU) is a term used to describe widened posterior seen mainly in girls. It commonly regarded as normal variant. The authors studied 30 girls with STU using videourodynamics. Twenty-eight showed bladder instability; 21, congenital wide neck anomaly; and 20, both instability neck. One patient had sensitive bladder. All patients urodynamic abnormality. believe that the nearly always an indication of or anomaly. most common mechanism for dilatation unstable contractions are...
We describe the use of Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) in investigation and diagnosis Charcot neuroarthropathy (CN) patients with a hot swollen foot but normal radiographs clinical suspicion CN, usually termed Stage 0. This was retrospective cohort review 46 diabetes who underwent 3 phase bone scintigraphy “High Resolution” SPECT/CT. The imaging demonstrated that 0 has distinct pathology, which can be classified into three groups: (1) fractures on...
Introduction. Small bowel neuroendocrine tumours (NETs) are the most common type of gastrointestinal tumours. The incidence and prevalence these on rise. aims this study were to determine prognostic clinicopathological features whether ENETS TNM staging system predicts prognosis also. Method. Clinical data was collected retrospectively from 138 patients with histologically proven small NETs managed at King's College Hospital. Histology reviewed bowels tumours, staged according system....
Autologous white blood cells were labelled with Indium 111 (111In wbc) and reinjected into 18 children suspected infection 10 inflammatory bowel disease aged 5 weeks to 15 years. In addition two immunosuppressed received donor 111In wbc. Gamma camera images obtained between one four hours 20 24 hours. Other appropriate investigations also undertaken in these children. Of positive wbc scans 17 true positive. There 12 negative of which 9 three false negative. The overall results showed a...
Bile acid malabsorption (BAM) is one possible explanation for chronic diarrhea. BAM may be idiopathic, or result from ileal resection inflammation including Crohn's disease, secondary to other conditions, cholecystectomy, peptic ulcer surgery, and pancreatitis. No "gold standard" exists clinical diagnosis of BAM, but response treatment with a bile sequestrant (BAS) often accepted as confirmation. The SeHCAT (tauroselcholic [selenium-75] acid) test uses radiolabeled synthetic provides...
Twenty-six children underwent a total of 75 99TCm-DTPA scans. Two experienced operators, using different techniques were able to identify parenchyme in 77 111 kidneys. Parenchymal regions interest drawn by an entirely operator dependent and relatively operator-independent technique. Transit time analysis, matrix algorithm, through the both normal abnormal kidneys showed high degree correlation (tau = 0.595, P less than 0.001). The technique concurred studies for which analysis could not be...
SUMMARY The aim of this study was to assess the status acquisition and reporting myocardial perfusion tomography in UK. Centres were asked provide an expert panel with clinical technical information, digital hard copy raw data reconstructed tomograms, as well their report (optional) for five randomly selected studies. Ninety studies received from 18 centres; text provided 66 Six parameters (stress technique, radiopharmaceutical usage, image processing, images text) scored good (2), adequate...
Introduction Perioperative mortality of patients who undergo heart valve surgery for carcinoid disease has been observed to be high (5%–10%). We investigated whether peptide receptor radiotherapy with lutetium-177 dotatate can used safely in neuroendocrine neoplasm and if there is associated survival advantage by reducing overall exposure the valves doses vasoactive peptides. Method Retrospective case notes review was performed on 18 (mean 60 years), underwent between 2003 2017 disease, 9...
Journal Article Age and dose-limited PET–CT scan regime in lymphoma: between the devil deep blue sea? Get access B. Sanghera, Sanghera * Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, UK *Corresponding author: bal.sanghera@nhs.net Search for other works by this author on: Oxford Academic PubMed Google Scholar L. I. Sonoda, Sonoda J. Hart, Hart G. Vivian, Vivian T. Mills, Mills W. Wong Radiation Protection Dosimetry, Volume 150, Issue 3, July 2012, Pages...
We present a case of patient, undergoing imaging for an unrelated presentation, whose adolescent abdominal trauma had caused unrecognised disseminated intra-abdominal splenosis, resulting in presentation on CT that suggested malignancy. The lack correlative symptoms malignancy, addition to findings suggesting previous upper trauma, led suggestion the lesion might represent spleen tissue. A denatured red cell scan with radio-labelled technetium-99m, allowed this tissue be confirmed as splenic...
A 65-year-old woman was hospitalized with pyrexia and lumbar back pain. Radiographs of her spine MRI were performed on the day admission results considered normal. Five days after admission, a Tc-99m MDP bone scan showed nonspecific increased uptake at L2–L3. Planar SPECT Ga-67 citrate scintigraphy tracer confirmed osteomyelitis this site. ciprofloxacin also infection Group B Streptococcus grew in blood cultures from patient, who improved clinically prolonged course antibiotics.