A5091238369- Animal testing and alternatives
- Immunotoxicology and immune responses
- Biosimilars and Bioanalytical Methods
- Computational Drug Discovery Methods
- Veterinary Pharmacology and Anesthesia
- Human-Animal Interaction Studies
- Animal Behavior and Welfare Studies
- Pharmaceutical Economics and Policy
- Effects and risks of endocrine disrupting chemicals
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacogenetics and Drug Metabolism
- Statistical Methods in Clinical Trials
- Parkinson's Disease Mechanisms and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Pharmaceutical studies and practices
- Childhood Cancer Survivors' Quality of Life
- Interpreting and Communication in Healthcare
- Pharmaceutical industry and healthcare
- Insect Utilization and Effects
- Healthcare innovation and challenges
- Cell Image Analysis Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Biofield Effects and Biophysics
- Axial and Atropisomeric Chirality Synthesis
- Patient Safety and Medication Errors
AstraZeneca (United Kingdom)
2010-2021
National Centre for the Replacement Refinement and Reduction of Animals in Research
2007-2016
Deakin University
2015
King's College London
2013
King's College Hospital NHS Foundation Trust
2013
Florida Atlantic University
2003
Oregon Health & Science University
1993
<h3>Objective</h3> Impulse control disorders are commonly associated with dopaminergic therapy in Parkinson9s disease (PD). PD patients impulse demonstrate enhanced dopamine release to conditioned cues and a gambling task on [<sup>11</sup>C]raclopride positron emission tomography (PET) imaging ventral striatal activity reward functional MRI. We compared age-matched gender-matched controls without using [<sup>123</sup>I]FP-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane) single photon computed...
Summary Objective Investigate associations of TV viewing time and accelerometry‐derived sedentary with inflammatory endothelial function biomarkers in children. Methods Cross‐sectional analysis 164 7–10‐year‐old was assessed by parental proxy report total patterns accumulation (e.g. prolonged bouts) were accelerometry. C ‐reactive protein ( CRP ), homeostasis model assessment insulin resistance, interleukin‐2, ‐6, ‐8, ‐10, tumour necrosis factor alpha, adiponectin, resistin, brain‐derived...
Short term toxicity studies are conducted in animals to provide information on major adverse effects typically at the maximum tolerated dose (MTD). Such important from a scientific and ethical perspective as they used make decisions progression of potential candidate drugs, set levels for subsequent regulatory studies. The MTD is usually determined by parameters such clinical signs, reductions body weight food consumption. However, these assessments often subjective there no published...
Clinical and nonclinical safety liabilities remain a major cause of adverse drug reactions, candidate attrition, delays during development, labelling restrictions, non-approval, product withdrawal. Many the toxicities are functional in nature and/or origin. Whereas pharmacological responses tend to be fairly rapid onset, therefore detectable after single dose, some diminish on repeated dosing, whereas others increase magnitude can missed or underestimated single-dose pharmacology studies....
The European Federation of Pharmaceutical Industries and Associations’ Research Animal Welfare group members reflected on the concept a Culture Care in relation to animal care use differences its understanding application across pharmaceutical companies. term ‘Culture Care’ is used different regions organizations but rarely with any defined indicators support working practice. has developed framework help identify gaps or potential areas for improvement positive Care. tool that identifies...
An international expert group which includes 30 organisations (pharmaceutical companies, contract research organisations, academic institutions and regulatory bodies) has shared data on the use of recovery animals in assessment pharmaceutical safety for early development. These have been used as an evidence-base to make recommendations inclusion toxicology studies achieve scientific objectives, while reducing animal use. Recovery are development provide information potential a toxic effect...
Before a potential new medicine can be administered to humans it is essential that its safety adequately assessed. Safety assessment in animals forms an integral part of this process, from early drug discovery and initial candidate selection the program recommended regulatory tests animals. The 3Rs (replacement, reduction, refinement research) are integrated current requirements expectations and, EU, provide legal ethical framework for vivo research ensure scientific objectives met whilst...
The dog is a frequently-used, non-rodent species in the safety assessment of new chemical entities. We have scientific and ethical obligation to ensure that best quality data achieved from their use. Oral gavage technique frequently used deliver compound directly into stomach. As with other animals, dog, aversive frequency its use cause for welfare concern but little research has been published on nor how Refine it. A Welfare Assessment Framework (Hall, 2014) was previously developed...
Background: The potential for whole blood sampling (20 µl) in toxicokinetic studies to reduce the sample volume was investigated. Blood microsamples were collected three ways, either as a dried spot (DBS), micropipette placed plastic tube and mixed with water or plasma normal manner. Results: samples on DBS microtube (WBMT) compared along determine data equivalency. WBMT comparison shown be equivalent, demonstrated correlation plot an R2 value of 0.97 x = y plot. also gave good correlation....
AstraZeneca ran a bespoke study to generate age-matched clinical pathology and histopathology data from cohort of Beagle dogs aged between 25 37 months support the use these older animals in routine preclinical toxicology studies. As upper age range routinely used studies does not normally exceed 24 months, there is an absence appropriate historical control data. The generation such was crucial understand whether age-related differences spontaneous findings might confound interpretation...