A5027884740- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Adipokines, Inflammation, and Metabolic Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiovascular and exercise physiology
- Metabolism and Genetic Disorders
- Vitamin C and Antioxidants Research
- Nutrition and Health in Aging
- Sports Performance and Training
- Cancer-related molecular mechanisms research
- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Muscle activation and electromyography studies
- Gestational Diabetes Research and Management
- Folate and B Vitamins Research
- Vitamin D Research Studies
- Mitochondrial Function and Pathology
- Bone health and osteoporosis research
- Transcranial Magnetic Stimulation Studies
- Birth, Development, and Health
- Thermoregulation and physiological responses
Deakin University
2015-2024
Karolinska Institutet
2022
Nutrition Sciences (Belgium)
2019
Background Over the course of ageing there is a natural and progressive loss skeletal muscle mass. The onset progression age-related wasting associated with an attenuated activation Akt-mTOR signalling protein synthesis in response to anabolic stimuli such as resistance exercise. MicroRNAs (miRNAs) are novel important post-transcriptional regulators numerous cellular processes. role miRNAs regulation following exercise poorly understood. This study investigated changes miRNA expression acute...
Abstract Aim: Production of reactive oxygen species (ROS) in skeletal muscle is markedly increased during exercise and may be essential for adaptation. We, therefore, investigated the effects infusion with antioxidant N ‐acetylcysteine (NAC) on exercise‐induced activation signalling pathways genes involved adaptation human muscle. Methods: Subjects completed two tests, 7 days apart, saline (control, CON) or NAC before exercise. Exercise tests comprised cycling at 71% 2peak 45 min, then 92%...
Intense resistance exercise causes a significant inflammatory response. NF-κB has been identified as prospective key transcription factor mediating the postexercise The purpose of this study was to determine whether single bout intense regulates signaling in human skeletal muscle. Muscle biopsy samples were obtained from vastus lateralis five recreationally active, but not strength-trained, males (21.9 ± 1.3 yr) prior to, and at 2 4 h following, exercise. A further subjects (4 males, 1...
Summary Objective Investigate associations of TV viewing time and accelerometry‐derived sedentary with inflammatory endothelial function biomarkers in children. Methods Cross‐sectional analysis 164 7–10‐year‐old was assessed by parental proxy report total patterns accumulation (e.g. prolonged bouts) were accelerometry. C ‐reactive protein ( CRP ), homeostasis model assessment insulin resistance, interleukin‐2, ‐6, ‐8, ‐10, tumour necrosis factor alpha, adiponectin, resistin, brain‐derived...
Testosterone, the major androgen, influences reproductive and non-reproductive systems in males females via binding to androgen receptor (AR). Both circulating endogenous testosterone muscle AR protein content are positively associated with mass strength males, but there is no such evidence females. Here, we tested whether levels were mass, function, or anabolic response resistance training pre-menopausal Twenty-seven pre-menopausal, untrained (aged 23.5 ± 4.8 years) underwent a 12-week...
In Crohn's disease (CD), skeletal muscle mass and function are reduced compared to healthy controls, potentially resulting in disability. Mechanisms contributing impairment, thus potential therapeutic targets, poorly understood. This study aimed measure compare size molecular targets involved growth, CD subjects controls. (n=27) (n=22) were recruited from the IBD outpatient clinic via local advertisement respectively. Demographics clinical data collected survey interview. Quadriceps...
The association of fatigue with decreased physical performance and underlying mechanisms are poorly understood in Crohn's disease (CD). We aimed to measure compare self-reported skeletal muscle CD subjects healthy controls, identify associated factors that may be amenable change.Demographic clinical data were collected assessed using the Fatigue Impact Scale (FIS) 27 consecutive patients 22 matched controls. Circulating cytokines growth measured. rate quadriceps was an isokinetic dynamometer...
Resistance-based blood flow restriction training (BFRT) improves skeletal muscle strength and size. Unlike heavy-load resistance (HLRT), there is debate as to whether adaptations following BFRT interventions can be primarily attributed concurrent hypertrophy, the magnitude of hypertrophy often minor. The present study aimed investigate effect 7 weeks HLRT on hypertrophy. expression protein growth markers from biopsy samples was also measured. Male participants were allocated moderately (HL;...
The phosphorylation of p70S6 Kinase (p70S6K) is an important step in the initiation protein translation. p70S6K enhanced with graded intakes whey after resistance exercise. Soy ingestion results lower muscle synthesis exercise compared whey; however, underlying mechanisms responsible for this difference have not been reported.13 older men (60-75) completed acute bout body and ingested 30 g soy or carbohydrate. Muscle biopsies were obtained rested fasted state 2 4 hours post Phosphorylation...
Resistance exercise and whey protein supplementation are effective strategies to activate muscle cell anabolic signaling ultimately promote increases in mass strength. In the current study, 46 healthy older men aged 60–75 (69.0 ± 0.55 years, 85.9 1.8 kg, 176.8 1.0 cm) performed a single bout of unaccustomed lower body resistance immediately followed by ingestion noncaloric placebo beverage or supplement containing 10, 20, 30, 40 g concentrate (WPC). Intramuscular amino acid levels biopsy...
Objective To test the efficacy of Transform-Us! school- and home-based intervention on children’s physical activity (PA), sedentary behaviour (SB) cardiometabolic risk factor profiles. Methods A 30-month 2×2 factorial design cluster randomised controlled trial delivered in 20 primary schools (148 Year 3 classes) Melbourne, Australia (2010–2012), that used pedagogical environmental strategies to reduce break up SB, promote PA or a combined approach, compared with usual practice. Primary...
Nonalcoholic fatty liver disease (NAFLD) affects approximately 30% of adults worldwide, with chronic low-grade inflammation being a key pathophysiological feature progression. The Mediterranean diet (MedDiet) is recognized for improving metabolic and hepatic outcomes in people diabetes NAFLD, part, via anti-inflammatory properties. aim this study was to determine the effect an ad libitum MedDiet versus low-fat (LFD) on inflammatory markers NAFLD. It hypothesized that MedDiet, its individual...
The JAK/STAT signaling pathway is essential for myogenic regeneration and regulated by a diverse range of ligands, including interleukin-6 (IL-6) platelet-derived growth factor-BB (PDGF-BB). Our aim was to evaluate the responsiveness IL-6 PDGF-BB intense exercise, along with STAT3 activation, before after 12 weeks resistance training. In young men, protein concentrations were quantified in biopsied muscle increased at 3 h post-exercise (17.5-fold 3-fold, respectively). response unaltered...
Skeletal muscle atrophy is a critical component of the ageing process. Age-related wasting due to disrupted protein turnover, process mediated in part by ubiquitin proteasome pathway (UPP). Additionally, older subjects have been observed an attenuated anabolic response, at both molecular and physiological levels, following single-bout resistance exercise (RE). We investigated expression levels UPP-related genes proteins involved degradation 10 (60-75 years) vs. younger (18-30 healthy male...