A5070258492- Muscle metabolism and nutrition
- Ovarian function and disorders
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Genetics and Physical Performance
- Muscle Physiology and Disorders
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Hormonal and reproductive studies
- Cardiovascular and exercise physiology
- Exercise and Physiological Responses
- Sports Performance and Training
- Nutrition and Health in Aging
- Muscle activation and electromyography studies
- Circular RNAs in diseases
- Bone health and osteoporosis research
- Ovarian cancer diagnosis and treatment
- Children's Physical and Motor Development
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Vitamin D Research Studies
- Endometriosis Research and Treatment
- Histone Deacetylase Inhibitors Research
- Genetics and Neurodevelopmental Disorders
Deakin University
2013-2025
Nutrition Sciences (Belgium)
2024
Victoria University
2017-2023
Victoria School of Management
2019-2023
Footscray Hospital
2018
The aim of this study was to investigate the effects 4 consecutive simulated night shifts on glucose homeostasis, mitochondrial function and central peripheral rhythmicities compared with a day shift schedule.Seventeen healthy adults (8M:9F) matched for sleep, physical activity dietary/fat intake participated in (night work n = 9; 8). Glucose tolerance insulin sensitivity before after nights were measured by an intravenous test hyperinsulinaemic euglycaemic clamp respectively. Muscles...
Abstract Women with PCOS have substantially greater symptoms of depression and anxiety, a lower health-related quality life (HRQoL) compared to women without PCOS. The aim this study was determine if high-intensity interval training (HIIT) could provide improvements in mental health outcomes than standard moderate-intensity continuous (MICT). Twenty-nine overweight aged 18–45 years were randomly assigned 12 weeks either MICT (60–75% HR peak , N = 15) or HIIT (> 90% 14). Outcome measures...
Testosterone, the major androgen, influences reproductive and non-reproductive systems in males females via binding to androgen receptor (AR). Both circulating endogenous testosterone muscle AR protein content are positively associated with mass strength males, but there is no such evidence females. Here, we tested whether levels were mass, function, or anabolic response resistance training pre-menopausal Twenty-seven pre-menopausal, untrained (aged 23.5 ± 4.8 years) underwent a 12-week...
The aim of this research was to examine the impact xanthine oxidase (XO) inhibitor allopurinol on skeletal muscle activation cell signaling kinases' and adaptations mitochondrial proteins antioxidant enzymes following acute endurance exercise training. Male Sprague-Dawley rats performed either (60 min treadmill running, 27 m/min, 5% incline) or 6 wk training (5 days/wk) while receiving vehicle. Allopurinol treatment reduced XO activity basal levels (P < 0.05), with uric acid being almost...
Abstract BACKGROUND Polycystic ovary syndrome (PCOS) is a major contributor to subfertility, diabetes and cardiovascular disease in women. The role of non-pharmacological interventions prevent these outcomes has been reported many systematic reviews, but robust conclusions have not made due variations the scope, quality findings reviews. OBJECTIVE AND RATIONALE Our aim was provide an overview existing evidence on effects women with PCOS fertility non-fertility by review SEARCH METHODS We...
Abstract Nearly all human complex traits and diseases exhibit some degree of sex differences, with epigenetics being one the main contributing factors. Various tissues display differences in DNA methylation; however, this has not yet been explored skeletal muscle, despite muscle among most transcriptomic differences. For first time, we investigated effect on autosomal methylation across three independent cohorts (Gene SMART, FUSION, GSE38291) using a meta-analysis approach, totalling 369...
Abstract STUDY QUESTION Does 12 weeks of high-intensity interval training (HIIT) result in greater improvements cardio-metabolic and reproductive outcomes compared to standard moderate-intensity continuous (MICT) women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER HIIT offers aerobic capacity, insulin sensitivity menstrual cyclicity, larger reductions hyperandrogenism MICT. WHAT IS KNOWN ALREADY Exercise is recognized improve clinical PCOS, but little known about whether results...
Abstract Background To investigate the association of adipocytokines and other inflammatory markers with development GDM. Methods Serum were studied at 12 to 15 weeks gestation using biobanked control samples from a randomised trial. Study participants identified as high risk for GDM validated clinical prediction tool. Markers tested commercial ELISA kits molecular weight (HMW) adiponectin, interleukin‐6 (IL‐6), plasminogen activator inhibitor‐1, visfatin, omentin‐1, sex‐hormone binding...
Mechanisms of insulin resistance in polycystic ovary syndrome (PCOS) remain ill defined, contributing to sub-optimal therapies. Recognising skeletal muscle plays a key role glucose homeostasis we investigated early signalling, its association with aberrant transforming growth factor β (TGFβ)-regulated tissue fibrosis. We also explored the impact aerobic exercise on these molecular pathways.
Scope Maternal vitamin D deficiency has been implicated in adverse pregnancy outcomes. However, the association between and inflammation, particularly adipokines, remains unexplored pregnancy. Methods results In 102 overweight or obese pregnant women at high‐risk of gestational diabetes mellitus (GDM), we investigated relationships maternal 25‐hydroxyvitamin (25(OH)D) concentrations 12–15 wk gestation (baseline) serum lipids, inflammatory markers, novel adipokines (omentin‐1, visfatin, high...
It remains unclear whether high-intensity interval exercise (HIIE) elicits distinct molecular responses to traditional endurance relative the total work performed. We aimed investigate influence of intensity on acute perturbations skeletal muscle mitochondrial function (respiration and reactive oxygen species) metabolic redox signaling responses. In a randomized, repeated measures crossover design, eight recreationally active individuals (24 ± 5 yr; V̇o2peak: 48 11 ml·kg-1·min-1) undertook...
Abstract Context Polycystic ovary syndrome (PCOS) is a chronic disease affecting reproductive function and whole-body metabolism. Although the etiology unclear, emerging evidence indicates that epigenetics may be contributing factor. Objective To determine role of global genome-wide epigenetic modifications in specific immune cells PCOS compared with controls whether these could related to clinical features PCOS. Design Cross-sectional study. Participants Women (n = 17) or without 17)....
Abstract Background Mitochondria have an essential role in regulating metabolism and integrate environmental physiological signals to affect processes such as cellular bioenergetics response stress. In the metabolically active skeletal muscle, mitochondrial biogenesis is one important component contributing a broad set of adaptations occurring signals, which converge on transcriptional regulator peroxisome proliferator-activated receptor coactivator 1-alpha (PGC-1α), central beneficial...
Exercise is a major beneficial contributor to muscle metabolism, and health benefits acquired by exercise are result of molecular shifts occurring across multiple layers (i.e., epigenome, transcriptome, proteome). Identifying robust, across-molecular level targets associated with response, at both group individual levels, paramount develop guidelines targeted interventions. Sixteen, apparently healthy, moderately trained (VO2 max = 51.0 ± 10.6 mL min-1 kg-1 ) males (age range 18-45 years)...
Abstract Purpose This study aimed to determine the inter-session reliability of quadriceps neuromuscular function measurements in healthy young and older females. Methods Twenty-six females aged 19–74 years completed two identical experimental sessions on different days. Quadriceps included isometric maximal voluntary force, high- low-frequency twitch evoked (H-reflex, M-wave) electromyography (EMG), estimated torque, velocity power derived from torque–velocity relationships. Intra-class...