A5064636464- Ovarian function and disorders
- Reproductive Biology and Fertility
- RNA modifications and cancer
- Pancreatic function and diabetes
- Muscle metabolism and nutrition
- Hormonal and reproductive studies
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Growth Hormone and Insulin-like Growth Factors
- Endometriosis Research and Treatment
- Hip and Femur Fractures
- Regulation of Appetite and Obesity
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Neuropeptides and Animal Physiology
- Bone health and osteoporosis research
- Ovarian cancer diagnosis and treatment
- Gestational Diabetes Research and Management
- Hair Growth and Disorders
- Genetics and Neurodevelopmental Disorders
- Menstrual Health and Disorders
- Menopause: Health Impacts and Treatments
- FOXO transcription factor regulation
- Nicotinic Acetylcholine Receptors Study
- Adipokines, Inflammation, and Metabolic Diseases
Nestlé (Switzerland)
2025
Victoria University
2017-2024
Australian Institute for Musculoskeletal Science
2019-2024
Western Health
2020-2023
The University of Melbourne
2020-2023
Victoria School of Management
2020
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2013-2017
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2014-2017
Institut d'Investigació Biomèdica de Girona
2013
Indiana University School of Medicine
2013
Abstract Context Polycystic ovary syndrome (PCOS) is a common endocrine condition affecting 8% to 13% of women across the lifespan. PCOS affects reproductive, metabolic, and mental health, generating considerable health burden. Advances in treatment with has been hampered by evolving diagnostic criteria poor recognition clinicians. This resulted limited clinical basic research. In this study, we provide insights into current future research on metabolic features PCOS, specifically as they...
Abstract Women with PCOS have substantially greater symptoms of depression and anxiety, a lower health-related quality life (HRQoL) compared to women without PCOS. The aim this study was determine if high-intensity interval training (HIIT) could provide improvements in mental health outcomes than standard moderate-intensity continuous (MICT). Twenty-nine overweight aged 18–45 years were randomly assigned 12 weeks either MICT (60–75% HR peak , N = 15) or HIIT (> 90% 14). Outcome measures...
Abstract STUDY QUESTION Does 12 weeks of high-intensity interval training (HIIT) result in greater improvements cardio-metabolic and reproductive outcomes compared to standard moderate-intensity continuous (MICT) women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER HIIT offers aerobic capacity, insulin sensitivity menstrual cyclicity, larger reductions hyperandrogenism MICT. WHAT IS KNOWN ALREADY Exercise is recognized improve clinical PCOS, but little known about whether results...
The pancreatic β-cell transcriptome is highly sensitive to external signals such as glucose oscillations and stress cues. MicroRNAs (miRNAs) have emerged key factors in gene expression regulation. Here, we aimed identify miRNAs that are modulated by mouse islets. We identified miR-708 the most upregulated miRNA islets cultured at low concentrations, a setting triggers strong response. was also potently triggering endoplasmic reticulum (ER) with thapsigargin of ob/ob mice. Low-glucose...
Abstract Background To investigate the association of adipocytokines and other inflammatory markers with development GDM. Methods Serum were studied at 12 to 15 weeks gestation using biobanked control samples from a randomised trial. Study participants identified as high risk for GDM validated clinical prediction tool. Markers tested commercial ELISA kits molecular weight (HMW) adiponectin, interleukin‐6 (IL‐6), plasminogen activator inhibitor‐1, visfatin, omentin‐1, sex‐hormone binding...
Mechanisms of insulin resistance in polycystic ovary syndrome (PCOS) remain ill defined, contributing to sub-optimal therapies. Recognising skeletal muscle plays a key role glucose homeostasis we investigated early signalling, its association with aberrant transforming growth factor β (TGFβ)-regulated tissue fibrosis. We also explored the impact aerobic exercise on these molecular pathways.
Scope Maternal vitamin D deficiency has been implicated in adverse pregnancy outcomes. However, the association between and inflammation, particularly adipokines, remains unexplored pregnancy. Methods results In 102 overweight or obese pregnant women at high‐risk of gestational diabetes mellitus (GDM), we investigated relationships maternal 25‐hydroxyvitamin (25(OH)D) concentrations 12–15 wk gestation (baseline) serum lipids, inflammatory markers, novel adipokines (omentin‐1, visfatin, high...
Abstract Context Polycystic ovary syndrome (PCOS) is a chronic disease affecting reproductive function and whole-body metabolism. Although the etiology unclear, emerging evidence indicates that epigenetics may be contributing factor. Objective To determine role of global genome-wide epigenetic modifications in specific immune cells PCOS compared with controls whether these could related to clinical features PCOS. Design Cross-sectional study. Participants Women (n = 17) or without 17)....
Introduction Sprint interval training (SIT) can elicit similar or even higher skeletal muscle mitochondrial adaptations than moderate-intensity continuous (MICT) despite a lower volume. We have previously shown that this is at least partially driven by improved bioenergetics with increased Ca2+ uptake and pyruvate dehydrogenase (PDH) activation after single session of SIT but not MICT [1]. Olive leaf extract (OLE) natural compound triggers activates PDH in mouse [2]. Here we tested the...
Polycystic ovary syndrome (PCOS) is a reproductive-metabolic condition. Insulin resistance hallmark of PCOS and related to increased hyperandrogenism that drives inherent metabolic, reproductive psychological features the syndrome. in women with managed by weight loss, lifestyle interventions (i.e. exercise, diet) insulin-sensitising medications. This manuscript describes protocol our study evaluating effectiveness high intensity intermittent training (HIIT) or moderate exercise on...
Immobilization leads to muscle wasting and insulin resistance, particularly during ageing. It has been suggested that undercarboxylated osteocalcin (ucOC) improves mass glucose metabolism. Bisphosphonates, an anti-osteoporosis treatment, might protect independent of ucOC. We hypothesize the combination ucOC ibandronate (IBN) treatments superior protective effects against immobilization-induced resistance than either treatment alone. C57BL/6J mice were hindlimb-immobilized for two weeks, with...
Women with polycystic ovary syndrome (PCOS), commonly have profound skeletal muscle insulin resistance which can worsen other clinical features. The heterogeneity of the condition has made it challenging to identify precise mechanisms that cause this resistance. A possible explanation for underlying may be dysregulation Transforming Growth Factor-beta (TGFβ) signalling. TGFβ signalling contributes remodelling reproductive and hepatic tissues in women PCOS. Given systemic nature its role...
Loss of functional β-cell mass is a key factor contributing to poor glycemic control in advanced type 2 diabetes (T2D). We have previously reported that the inhibition neuropeptide Y1 receptor improves islet transplantation outcome 1 (T1D). The aim this study was identify pathophysiological role Y (NPY) system human T2D and further evaluate therapeutic potential using antagonist BIBO3304 improve function survival T2D. gene expression NPY islets from nondiabetic subjects with determined...
Background Bone and muscle are closely linked anatomically, biochemically, metabolically. Acute exercise affects both bone muscle, implying a crosstalk between the two systems. However, how these systems communicate is still largely unknown. We will explore role of undercarboxylated osteocalcin (ucOC) in this crosstalk. ucOC involved glucose metabolism has potential maintenance metabolism. Objective The proposed trial determine if circulating levels older adults at baseline following acute...
Physical exercise and activity status may modify the effect of fat mass- obesity-associated (FTO) genotype on body weight obesity risk. To understand interaction between FTO's physical activity, present study investigated effects high low intensity FTO mRNA protein expression, potential modifiers exercise-induced changes in healthy-weighted individuals.Twenty-eight untrained males females (25.4 ± 1.1 years; 73.1 2.0 kg; 178.8 1.4 cm; 39.0 1.2 ml.kg.min- 1 VO2peak) were genotyped for...
Large conductance calcium-activated potassium (BK) channels are widely expressed in the nervous system. We have recently shown that principal neurons from canine intracardiac ganglia (ICG) express a paxilline- and TEA-sensitive BK current, which increases neuronal excitability. In present work, we further explore molecular constituents of current ICG. found β1 β4 regulatory subunits Single channel voltage-dependence at different calcium concentrations suggested association BKα with...