A5054077584- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Viral Infections and Outbreaks Research
- Animal testing and alternatives
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Animal Disease Management and Epidemiology
- Biomedical and Engineering Education
- Higher Education Learning Practices
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
- Nanoplatforms for cancer theranostics
- Clinical Reasoning and Diagnostic Skills
- Xenotransplantation and immune response
- Inhalation and Respiratory Drug Delivery
- Animal Genetics and Reproduction
- Agricultural safety and regulations
- Health and Medical Research Impacts
- Viral gastroenteritis research and epidemiology
- COVID-19 and Mental Health
- COVID-19 diagnosis using AI
- Innovations in Medical Education
Erasmus University Rotterdam
2014-2024
Erasmus MC
2014-2022
European Clinical Research Infrastructure Network
2021
European Research Infrastructure on Highly Pathogenic Agents
2021
Coronavirus in nonhuman primates We urgently need vaccines and drug treatments for coronavirus disease 2019 (COVID-19). Even under these extreme circumstances, we must have animal models rigorous testing of new strategies. Rockx et al. undertaken a comparative study three human coronaviruses cynomolgus macaques: severe acute respiratory syndrome–coronavirus (SARS-CoV) (2002), Middle East syndrome (MERS)–CoV (2012), SARS-CoV-2 (2019), which causes COVID-19 (see the Perspective by Lakdawala...
Abstract SARS-CoV-2, a coronavirus that emerged in late 2019, has spread rapidly worldwide, and information about the modes of transmission SARS-CoV-2 among humans is critical to apply appropriate infection control measures slow its spread. Here we show transmitted efficiently via direct contact air (via respiratory droplets and/or aerosols) between ferrets, 1 3 days 7 after exposure respectively. The pattern virus shedding indirect recipient ferrets similar inoculated infectious isolated...
Abstract SARS-CoV-2, the causative agent of COVID-19 1 , features a receptor-binding domain (RBD) for binding to host cell ACE2 protein 1–6 . Neutralizing antibodies that block RBD-ACE2 interaction are candidates development targeted therapeutics 7–17 Llama-derived single-domain (nanobodies, ~15 kDa) offer advantages in bioavailability, amenability, and production storage owing their small sizes high stability. Here, we report rapid selection 99 synthetic nanobodies (sybodies) against RBD by...
SARS-CoV-2, a coronavirus that newly emerged in China late 2019 1,2 and spread rapidly worldwide, caused the first witnessed pandemic sparked by coronavirus. As progresses, information about modes of transmission SARS-CoV-2 among humans is critical to apply appropriate infection control measures slow its spread. Here we show transmitted efficiently via direct contact air (via respiratory droplets and/or aerosols) between ferrets. Intranasal inoculation donor ferrets resulted productive upper...
Abstract A novel coronavirus, SARS-CoV-2, was recently identified in patients with an acute respiratory syndrome, COVID-19. To compare its pathogenesis that of previously emerging coronaviruses, we inoculated cynomolgus macaques SARS-CoV-2 or MERS-CoV and compared historical SARS-CoV infections. In SARS-CoV-2-infected macaques, virus excreted from nose throat absence clinical signs, detected type I II pneumocytes foci diffuse alveolar damage mucous glands the nasal cavity....
An essential step for SARS-CoV-2 infection is the attachment to host cell receptor by its Spike receptor-binding domain (RBD). Most of existing RBD-targeting neutralizing antibodies block motif (RBM), a mutable region with potential generate neutralization escape mutants. Here, we isolated and structurally characterized non-RBM-targeting monoclonal antibody (FD20) from convalescent patients. FD20 engages RBD at an epitope distal RBM KD 5.6 nM, neutralizes including current Variants Concern...
Article 23(2) of the European Union Directive 2010/63/EU, which regulates welfare provisions for animals used scientific purposes, requires that staff involved in care and use purposes be adequately educated trained before they undertake any such work. However, nature extent training is not stipulated Directive. To facilitate Member States fulfilling their education obligations, Commission developed a common Education Training Framework, was endorsed by Competent Authorities. An &...
This document provides assessment criteria for evaluation of each the Learning Outcomes Modules specified (in addition to Core Modules) those designing procedures and projects in Education Training Framework guidance by European Commission endorsed Member States Competent Authorities. Working Group was tasked produce these & Platform Laboratory Animal Science, which funded this aim. The address knowledge skills (including critical thinking) expected be acquired during education training...