A5031112086- Platelet Disorders and Treatments
- Animal testing and alternatives
- Heparin-Induced Thrombocytopenia and Thrombosis
- Computational Drug Discovery Methods
- Retinal and Optic Conditions
- Pharmaceutical studies and practices
- Neonatal Health and Biochemistry
- Drug-Induced Ocular Toxicity
- Biosimilars and Bioanalytical Methods
- Connexins and lens biology
- Connective tissue disorders research
- Urinary Bladder and Prostate Research
- Immunotoxicology and immune responses
- Veterinary Pharmacology and Anesthesia
- Intramuscular injections and effects
- Growth Hormone and Insulin-like Growth Factors
- Renal and related cancers
- Blood groups and transfusion
- Retinal Development and Disorders
Janssen (Belgium)
2012-2024
Short term toxicity studies are conducted in animals to provide information on major adverse effects typically at the maximum tolerated dose (MTD). Such important from a scientific and ethical perspective as they used make decisions progression of potential candidate drugs, set levels for subsequent regulatory studies. The MTD is usually determined by parameters such clinical signs, reductions body weight food consumption. However, these assessments often subjective there no published...
An international expert working group representing 37 organisations (pharmaceutical/biotechnology companies, contract research organisations, academic institutions and regulatory bodies) collaborated in a data sharing exercise to evaluate the utility of two species within general toxicology studies. Anonymised on 172 drug candidates (92 small molecules, 46 monoclonal antibodies, 15 recombinant proteins, 13 synthetic peptides 6 antibody-drug conjugates) were submitted by 18 organisations. The...
Ad26.COV2.S vaccination can lead to vaccine-induced immune thrombotic thrombocytopenia (VITT), a rare but severe adverse effect, characterized by and thrombosis. The mechanism of VITT induction is unclear likely multifactorial, potentially including the activation platelets endothelial cells mediated vaccine-encoded spike protein (S protein). Here, we investigated biodistribution S after dosing in three animal models human serum samples. was transiently present draining lymph nodes rabbits...
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a very rare but serious adverse reaction that can occur after Ad26.COV2.S vaccination in humans, leading to thrombosis at unusual anatomic sites. One hypothesis accidental intravenous (IV) administration of or drainage the vaccine from muscle into circulatory system may result interaction with blood factors associated platelet activation, VITT. Here, we demonstrate that, similar intramuscular (IM) rabbits, IV dosing was well...
Fetal examinations in embryo-fetal developmental (EFD) studies are based on macroscopic and dissecting microscopic evaluations, histopathology is rarely performed other than to confirm findings. lens examination therefore generally limited the presence, size, shape, color of any abnormality. In a Sprague-Dawley rat EFD study with fatty acid amide hydrolase (FAAH) inhibitor JNJ-42165279, an unusually high incidence granular foci was noted within gestation day 21 fetuses across all groups...