A5080981105- Advanced Radiotherapy Techniques
- Advanced Glycation End Products research
- Radiation Therapy and Dosimetry
- Bladder and Urothelial Cancer Treatments
- Advances in Oncology and Radiotherapy
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Experimental Learning in Engineering
- X-ray Spectroscopy and Fluorescence Analysis
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Radiation Detection and Scintillator Technologies
- Esophageal Cancer Research and Treatment
- Long-Term Effects of COVID-19
- Drug-Induced Adverse Reactions
- Heavy Metal Exposure and Toxicity
- Cardiac Imaging and Diagnostics
- Anatomy and Medical Technology
- Plant tissue culture and regeneration
- Respiratory Support and Mechanisms
- Alcohol Consumption and Health Effects
- Mercury impact and mitigation studies
- Prostate Cancer Diagnosis and Treatment
- Electromagnetic Compatibility and Noise Suppression
- Pharmacogenetics and Drug Metabolism
Clinical Centre of Kragujevac
2013-2024
McGill University Health Centre
2013-2024
McGill University
2004-2021
Montreal General Hospital
2015-2019
Institute of Public Health of Serbia
2017
Jewish General Hospital
2015
Vantage View (United States)
2015
Eli Lilly (United States)
2012-2013
University of Toronto
2004-2012
Croatian Forest Research Institute
2008-2012
In 1994, 207 women participated in a study designed to examine the effects of occupational exposure and various lifestyle factors on bone blood lead levels. vivo measurements Pb concentrations tibia were performed by X-ray fluorescence. All 108 former smelter employees 99 referents provided samples answered questionnaire characteristics relevant medical history. Lead significantly higher exposed group. The difference mean two groups is markedly greater than concentrations, supporting view...
Short term toxicity studies are conducted in animals to provide information on major adverse effects typically at the maximum tolerated dose (MTD). Such important from a scientific and ethical perspective as they used make decisions progression of potential candidate drugs, set levels for subsequent regulatory studies. The MTD is usually determined by parameters such clinical signs, reductions body weight food consumption. However, these assessments often subjective there no published...
Although radical cystectomy surgery is the standard-of-care for muscle-invasive bladder cancer, it entails complete removal of and surrounding organs which leads to substantial loss in quality-of-life patients. Radiotherapy, spares bladder, would be a more appropriate treatment modality if we can utilize molecular markers select patients with better response radiation. In this study, investigate protein called high mobility group box 1 (HMGB1) as predictive marker radiotherapy cancer. Our...
Previously, we reported a new animal model of an idiosyncratic drug reaction in which nevirapine causes skin rash some rats that has characteristics similar to the occurs humans. Strong evidence is immune-mediated was found; specifically, low-dose pretreatment induced tolerance, while with rechallenge, time onset decreased and severity increased. Furthermore, splenocytes from rechallenged transferred susceptibility naïve recipients. We now report results studies explore immune aspects this...
Nevirapine, used for the treatment of HIV infection, is associated with development skin rash and liver toxicity. The mechanism these idiosyncratic reactions unknown. We have previously reported discovery a new animal model nevirapine-induced in rats. When treated nevirapine, Brown Norway rats developed red ears on about day 7 21. On rechallenge, turn within 24 h, lesions develop by 9. In current study, we analyzed time course sequence events involved rash. Rats were nevirapine 7, 14, or 21...
Electronic brachytherapy sources are widely accepted as alternatives to radionuclide-based systems. Yet, formal dosimetry standards for these devices independently complement the dose protocol provided by manufacturer lacking. This article presents a formalism calculating and verifying absorbed water from kV x-ray source (The INTRABEAM System) measured in phantom with an ionization chamber calibrated terms of air-kerma. uses Monte Carlo (MC) calculated conversion factor, [Formula: see text],...
Covalent binding of drug reactive metabolites to neutrophils or their precursors is thought play a role in the development drug-induced agranulocytosis. In this study, we used immunochemical techniques compare covalent clozapine, vesnarinone, and procainamide (three drugs associated with agranulocytosis) phorbol-12,13-myristate acetate (PMA)-activated human vitro rat tissues vivo. PMA-activated vitro, clozapine modified neutrophil proteins molecular masses ranging from 30 200 kDa, while...
Felbamate (2-phenyl-1,3-propanediol dicarbamate, FBM) can cause aplastic anemia and hepatotoxicity. The mechanism of FBM-induced toxicities is unknown; however, it has been proposed that 2-phenylpropenal, a reactive metabolite FBM, responsible. pathway leading to this involves hydrolysis FBM 2-phenyl-1,3-propandiol monocarbamate (MCF), oxidation 3-carbamoyl-2-phenylpropionaldehyde (CBMA), spontaneous loss carbon dioxide ammonia. We made polyclonal antibody against 2-phenylpropenal bound...
Aim: We aimed to single out admission predictors of acute respiratory distress syndrome (ARDS) in hospitalized COVID-19 patients and investigate the role bioelectrical impedance (BIA) measurements ARDS development. Method: An observational, prospective cohort study was conducted on 407 consecutive at University Clinical Center Kragujevac between September 2021 March 2022. Patients were followed during hospitalization, observed as a primary endpoint. Body composition assessed using BMI, body...
Tienilic acid (TA) was withdrawn due to idiosyncratic hepatotoxicity. Two hypotheses for the mechanisms of reactions are hapten and danger hypotheses, which not mutually exclusive. Both human CYP 2C9 rat 2C11 metabolize TA a reactive metabolite that reported bind exclusively these enzymes. TA-Induced liver toxicity is associated with antibodies against 2C9, thus appears act as hapten. However, if binding were limited 2C, it unlikely this would lead significant cell stress. If does cause...
The purpose of this report is to provide detailed guidance on the dosimetry INTRABEAM® (Carl Zeiss Medical AG, Jena, Germany) electronic brachytherapy (eBT) system as it stands at present time. This has been developed by members American Association Physicists in Medicine (AAPM) Task Group 292 and endorsed AAPM. Members AAPM Electronic‐Brachytherapy Dosimetry have reviewed pertinent publications user manuals regarding INTRABEAM manufacturer‐supplied dose calculation protocols. Formal written...
Background: Early prediction of COVID-19 patients’ mortality risk may be beneficial in adequate triage and assessment. Therefore, we aimed to single out the independent morality predictors hospitalized patients among parameters available on hospital admission. Methods: An observational, retrospective−prospective cohort study was conducted 703 consecutive University Clinical Center Kragujevac between September December 2021. Patients were followed during hospitalization, in-hospital observed...
[Purpose] The purpose of this study was to determine the effects short-term exercise training on cardiorespiratory fitness (CRF) individuals suffering from myocardial infarction. [Subjects] A total 60 participants were divided into experimental (EXP; n=30, mean age 56.7 ± 2.8 years, body mass 80.7 10.7 kg, height 171.9 7.2 cm) and control (CON; 56.5 3.1 84.4 12.4 171.5 groups. [Methods] members EXP group took part in an organized daily physical program (Monday through Sunday), for a period 3...
The INTRABEAM system (Carl Zeiss Meditec AG, Jena, Germany) is an electronic brachytherapy (eBT) device designed for intraoperative radiotherapy applications. To date, the x-ray source has not been characterized according to AAPM TG-43 specifications sources. This restricts its modelling in commercial treatment planning systems (TPSs), with consequence that doses organs at risk are unknown. aim of this work characterize dosimetry protocol. dose distribution water around was determined Monte...