A5049782124- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Endometrial and Cervical Cancer Treatments
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Nonmelanoma Skin Cancer Studies
- Radiation Dose and Imaging
- Radiopharmaceutical Chemistry and Applications
- Nuclear Physics and Applications
- Cutaneous Melanoma Detection and Management
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Prostate Cancer Treatment and Research
- Ocular Oncology and Treatments
- Prostate Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- AI in cancer detection
- Nanoplatforms for cancer theranostics
- Advanced Neural Network Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Medical Imaging and Pathology Studies
- Radiation Shielding Materials Analysis
- Advanced X-ray Imaging Techniques
Carleton University
2020-2022
Sunnybrook Health Science Centre
2015-2019
Health Sciences Centre
2015-2019
Sunnybrook Research Institute
2015-2018
Shiraz University
2018
Islamic Azad University of Shiraz
2014-2018
Sunnybrook Hospital
2016-2017
University of Toronto
2015-2017
Aarhus University
2015
University of California, San Diego
2015
In this paper, the effectiveness and capability of convolutional neural networks have been studied in classification 8 skin diseases. Different pre-trained state-of-the-art architectures (DenseNet 201, ResNet 152, Inception v3, InceptionResNet v2) were used applied on 10135 dermoscopy images total (HAM10000: 10015, PH2: 120). The utilized dataset includes diagnostic categories - melanoma, melanocytic nevi, basal cell carcinoma, benign keratosis, actinic keratosis intraepithelial...
Purpose To evaluate the possibility of utilizing high‐dose rate ( HDR ) 169 Yb and 60 Co sources, in addition to 192 Ir, for treatment skin malignancies with conical applicators. Methods Monte Carlo MC simulations were used benchmark dosimetric parameters single (4140), (Co0.A86), Ir mHDR ‐V2) brachytherapy sources a water phantom compared their results against published data. A standard tungsten alloy Leipzig‐style applicator (Stand.Appl) was determination dose distributions at various...
Purpose To evaluate plan quality of a novel MRI‐compatible direction modulated brachytherapy (DMBT) tandem applicator using 192 Ir, 60 Co, and 169 Yb HDR sources, for various cervical cancer high‐risk clinical target volumes (CTV HR ). Materials Methods The DMBT has six peripheral grooves 1.3‐mm diameter along 5.4‐mm thick nonmagnetic tungsten alloy rod. Monte Carlo (MC) simulations were used to benchmark the dosimetric parameters sources in water phantom against literature data. 45 cases...
To update the Carleton Laboratory for Radiotherapy Physics (CLRP) TG-43 dosimetry database low-energy (≤50 keV) photon-emitting low-dose rate (LDR) brachytherapy sources utilizing open-source EGSnrc application egs_brachy rather than BrachyDose used previously 27 LDR in 2008 CLRP version (CLRPv1). CLRPv2 covers 40 ( 103 Pd, 125 I, and 131 Cs). A comprehensive set of parameters is calculated, including dose-rate constants, radial dose functions with functional fitting parameters, 1D 2D...
Several different applicators have been designed for treatment of skin cancers, such as scalp, hand, and legs using Ir-192 HDR brachytherapy sources (IR-HDRS), miniature electronic (eBT), external electron beam radiation therapy (EEBRT). Although, all these methodologies may deliver the desired dose to skin, but underlying bone become limiting factor selection optimum technique. In this project, has evaluated a function type, thickness bone, soft tissue on top assuming same delivery skin....
To update and extend version 2 of the Carleton Laboratory for Radiotherapy Physics (CLRP) TG-43 dosimetry database (CLRP_TG43v2) high-energy (HE, ≥50 keV) brachytherapy sources (1 169 Yb, 23 192 Ir, 5 137 Cs, 4 60 Co) using egs_brachy, an open-source EGSnrc application. A comprehensive dataset parameters is compiled, including detailed source descriptions, dose-rate constants, radial dose functions, 1D 2D anisotropy along-away tables, Primary Scatter Separated (PSS) mean photon energies...
Purpose To investigate the dose modulation capability of a novel MRI ‐compatible direction modulated brachytherapy ( DMBT ) tandem applicator design with various high‐density shielding materials for treatment cervical cancer. The shield that have been evaluated are tantalum (Ta), pure tungsten (W), gold (Au), rhenium (Re), osmium (Os), platinum (Pt), iridium (Ir), and W′ alloy (95%W, 3.5%Ni, 1.5%Cu). Materials methods recently proposed six‐channel is composed nonmagnetic (W′) rod diameter...
Purpose: The goal of this study is to determine a method for Monte Carlo (MC) characterization the miniature electronic brachytherapy x‐ray sources (MEBXS) and set dosimetric parameters according TG‐43U1 formalism. were used get optimal designs MEBXS. Parameters that affect dose distribution such as anode shapes, target thickness, angles, electron beam source characteristics evaluated. Optimized MEBXS obtained radial functions 2D anisotropy in energy range 25–80 keV. Methods: Tungsten...
Brachytherapy treatment planning systems (BTPS) are employing the American Association of Physicists in Medicine (AAPM) Task Group 43 (TG-43)-recommended dosimetric parameters sources, which measured water. The majority brachytherapy implant volumes not homogeneous media. Particularly, an with multiple seeds significantly changes homogeneity volume. Heterogeneities, such as attenuation by adjacent or interseed (ISA), neglected to this day all BTPS. goal project is determine a novel...
The purpose of this report is to provide detailed guidance on the dosimetry INTRABEAM® (Carl Zeiss Medical AG, Jena, Germany) electronic brachytherapy (eBT) system as it stands at present time. This has been developed by members American Association Physicists in Medicine (AAPM) Task Group 292 and endorsed AAPM. Members AAPM Electronic‐Brachytherapy Dosimetry have reviewed pertinent publications user manuals regarding INTRABEAM manufacturer‐supplied dose calculation protocols. Formal written...
Dosimetry of proton beams is generally evaluated in liquid water, or alternatively solid phantoms via water equivalent ratios (WER). WER defined as the ratio range to that a phantom certain material. Presently, not available literature neither for wide energies nor variety relevant materials. Thus, goal this study provide such data through Monte Carlo simulations. calculated 10–500 MeV compact bone, adipose tissue, polymethyl methacrylate (PMMA), PTFE (teflon), graphite (C), aluminum (Al),...
Purpose The purpose of this study was to provide guidance on quality management for electronic brachytherapy. Materials and Methods task group used the risk‐assessment approach Task Group 100 American Association Physicists in Medicine. Because program a device is intimately tied procedure which it used, first designed interventions intracavitary brachytherapy both commercial units setting accelerated partial‐breast irradiation. To demonstrate methodology extend an existing risk analysis...
<p><strong>Background and purpose:</strong> Permanent seed brachytherapy is an established treatment option for localized prostate cancer. Currently, post-implant dosimetry performed on CT images despite challenging target delineation due to limited soft tissue contrast. This work aims develop MRI-only workflow of seeds.</p> <p><strong>Material methods:</strong> A mimicking phantom containing twenty stranded I-125 dummy seeds calcifications was...
<p><strong>Background and purpose:</strong> Permanent seed brachytherapy is an established treatment option for localized prostate cancer. Currently, post-implant dosimetry performed on CT images despite challenging target delineation due to limited soft tissue contrast. This work aims develop MRI-only workflow of seeds.</p> <p><strong>Material methods:</strong> A mimicking phantom containing twenty stranded I-125 dummy seeds calcifications was...
To update and extend the Carleton Laboratory for Radiotherapy Physics (CLRP) Eye Plaque (EP) dosimetry database low-energy photon-emitting brachytherapy sources using egs_brachy, an open-source EGSnrc application. The previous database, CLRP_EPv1, contained datasets Collaborative Ocular Melanoma Study (COMS) plaques (10-22 mm diameter) with 103 Pd or 125 I seeds (BrachyDose-computed, 2008). new CLRP_EPv2, consists of newly calculated three-dimensional (3D) dose distributions 17 [eight COMS,...
Purpose: To evaluate the improvement in plan quality when various combinations of 192Ir, 60Co, and 169Yb sources are used combination with a novel direction modulated brachytherapy (DMBT) tandem applicator for high dose rate cervical cancer. Methods: The proposed DMBT is designed image‐guided adaptive (IGABT), especially MRI, It has 6 peripheral holes 1.3‐mm width, grooved along 5.4‐mm diameter nonmagnetic tungsten alloy rod density 18.0 g/cc, capable generating directional profiles ‐...