A5040714094- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Peripheral Artery Disease Management
- Pressure Ulcer Prevention and Management
- Skin Diseases and Diabetes
- Bone and Joint Diseases
- Diagnosis and Treatment of Venous Diseases
- Botulinum Toxin and Related Neurological Disorders
- Pain Mechanisms and Treatments
- Streptococcal Infections and Treatments
- Heart Rate Variability and Autonomic Control
- Pain Management and Treatment
- Bone Metabolism and Diseases
- Infrared Thermography in Medicine
- Orthopedic Infections and Treatments
- Diabetes Management and Research
- Foot and Ankle Surgery
- Cardiovascular Syncope and Autonomic Disorders
- Reconstructive Surgery and Microvascular Techniques
- Neurological and metabolic disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Parkinson's Disease Mechanisms and Treatments
- Diabetes and associated disorders
- Tendon Structure and Treatment
- Systemic Sclerosis and Related Diseases
University of Toronto
2025
King's College Hospital
2015-2024
King's College Hospital NHS Foundation Trust
2015-2024
King's College London
2006-2024
The University of Kansas Cancer Center
2024
University of Milan
2023
National Health Service
2005-2021
King's College - North Carolina
1997-2020
Diabetes UK
1986-2018
Royal London Hospital
2017-2018
Outcome data on individuals with diabetic foot ulcers are scarce, especially in those peripheral arterial disease (PAD). We therefore examined the clinical characteristics that best predict poor outcome a large population of ulcer patients and whether such predictors differ between without PAD.Analyses were conducted within EURODIALE Study, prospective cohort study 1,088 across 14 centres Europe. Multiple logistic regression modelling was used to identify independent (i.e. non-healing...
A specialised foot clinic for diabetic patients has made a detailed analysis of the presentation ulcers and from this new, organised approach to treatment been derived. Over three years it achieved high rate ulcer healing reduced number major amputations. It brought together skills chiropodist, shoe-fitter, nurse, physician surgeon manage distinctive lesions neuropathic ischaemic foot. The was invariably associated with callus, whereas presented as areas necrosis often localised pressure...
The diabetic Charcot foot syndrome is a serious and potentially limb-threatening lower-extremity complication of diabetes. First described in 1883, this enigmatic condition continues to challenge even the most experienced practitioners. Now considered an inflammatory syndrome, characterized by varying degrees bone joint disorganization secondary underlying neuropathy, trauma, perturbations metabolism. An international task force experts was convened American Diabetes Association Podiatric...
Infection commonly complicates diabetic foot ulcers and is associated with a poor outcome. In cohort of individuals an infected ulcer, we aimed to determine independent predictors lower-extremity amputation the predictive value for International Working Group on Diabetic Foot (IWGDF) classification system develop risk score predicting amputation.We prospectively studied 575 patients ulcer presenting 1 14 clinics in 10 European countries.Among these patients, 159 (28%) underwent amputation....
The aim was to evaluate over 18 months whether depression associated with mortality in people their first foot ulcer.A prospective cohort design used. Adults diabetic ulcer were recruited from clinics southeast London, U.K. At baseline, the Schedules for Clinical Assessment Neuropsychiatry 2.1 used define those who met DSM (Diagnostic and Statistical Manual of Mental Disorders)-IV criteria minor major depressive disorders. Potential covariates age, sex, marital status, socioeconomic smoking,...
X-ray examinations of the feet, knees, and hands were performed on 20 diabetics with severe neuropathy no evidence but a similar mean age duration diabetes. All under 53 years old clinical peripheral vascular disease. Medial arterial calcification was much more common extensive in patients neuropathy, occurring feet 15 eight compared four (p less than 0.001) none controls respectively. Although there some correlation between both proteinuria 0.05) proliferative retinopathy 0.02), association...
This study compared the efficacy and safety of Apligraf (Organogenesis, Inc., Canton, MA) in combination with standard therapy versus alone treatment neuropathic diabetic foot ulcers. Efficacy was assessed by time to complete wound healing (by 12 weeks) incidence closure (at weeks). an international multi-center, randomized, controlled study. Patients were eligible for entry into if following criteria met: type 1 or 2 diabetes mellitus, age 18 80 years, adequate glycemic control, presence a...
OBJECTIVE To describe recent trends in the incidence of nontraumatic amputations among individuals with and without diabetes estimate relative risk England. RESEARCH DESIGN AND METHODS We identified all patients aged >16 years who underwent any amputation England between 2004 2008 using national hospital activity data from National Health Service hospitals. Age- sex-specific rates were calculated total population every year. test for time trend, we fitted Poisson regression models....
Diabet. Med. 28, 199–205 (2011) Abstract Objectives The incidence of minor amputation may vary significantly, and determinants have not been studied systematically. We evaluated rate, the differences in rate between European centres. Methods In Eurodiale study, a prospective cohort study 1232 patients (1088 followed until end‐point) with new diabetic foot ulcer were on monthly basis healing, death, major or up to maximum 1 year. Ulcers treated according international guidelines. Baseline...
Our aims were to compare osteoclastic activity between patients with acute Charcot's osteoarthropathy and diabetic healthy controls, determine the effect of receptor activator nuclear factor-kappaB ligand (RANKL) its decoy osteoprotegerin (OPG).Peripheral blood monocytes isolated from nine Charcot patients, eight control participants cultured in presence macrophage-colony stimulating factor (M-CSF) alone, M-CSF RANKL, also RANKL excess concentrations OPG. Osteoclast formation was assessed by...
Diabetic foot ulcer (DFU) patients have a greater than twofold increase in mortality compared with nonulcerated diabetic patients. We investigated (a) cause of death DFU patients, (b) age at death, and (c) relationship between type. This was an eleven-year retrospective study on who attended King's College Hospital Foot Clinic subsequently died. A control group matched for type diabetes mellitus. The identified from certificates (DC) postmortem (PM) examinations. There were 243 patient...
Topical oxygen has been used for the treatment of chronic wounds more than 50 years. Its effectiveness remains disputed due to limited number robust high-quality investigations. The aim this study was assess efficacy multimodality cyclical pressure Wound Oxygen (TWO2) home care therapy in healing refractory diabetic foot ulcers (DFUs) that had failed heal with standard (SOC) alone.Patients diabetes and DFUs were randomized (double-blind) either active TWO2 or sham control therapy-both...