A5015786047- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal Transplantation Outcomes and Treatments
- Neuroendocrine Tumor Research Advances
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Transplantation: Methods and Outcomes
- Pancreatic function and diabetes
- Pediatric Hepatobiliary Diseases and Treatments
- COVID-19 and healthcare impacts
- Organ Donation and Transplantation
- Congenital Anomalies and Fetal Surgery
- Lung Cancer Research Studies
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- Diabetes and associated disorders
- Diabetes Management and Research
- Cancer Genomics and Diagnostics
King's College Hospital NHS Foundation Trust
2012-2025
King's College Hospital
2016-2025
Swami Vivekanand College of Pharmacy
2023
Royal Marsden NHS Foundation Trust
2023
King's College - North Carolina
2000-2023
Cambridge University Hospitals NHS Foundation Trust
2023
Liechtenstein Institute
2023
Kings Health Partners
2012-2016
Development Fund
2016
King's College London
2005-2015
To assess the incidence and impact of biliary complications in recipients transplanted from donors after cardiac death (DCD) at one single large institution.Shortage available cadaveric organs is a significant limiting factor liver transplantation (LT). The use DCD offers potential to increase organ pool. However, early results with grafts were associated greater ischemic cholangiopathy (IC), leading several programs abandoning this source organs.A retrospective analysis prospective database...
Budd-Chiari syndrome (BCS) is a clinical condition characterized by hepatic venous outflow obstruction secondary to an underlying systemic predisposition thrombosis.We reviewed our experience of 19 adult patients who underwent orthotopic liver transplantation for BCS from April 1988 May 1999 assess their long-term outcome and specific complications related this procedure.Of these patients, 13 presented with chronic 6 acute failure. At presentation predisposing factors included polycythemia...
To report our experience of prospectively identifying and transplanting livers into HIV-positive patients.Liver transplantation in patients remains controversial. The finding HIV is usually considered a contraindication to any form transplantation. Previously reported cases are few refer who tested positive after they had their liver transplantations or seroconverted the posttransplantation period. This is, knowledge, only were known be at time decision for listing transplantation.The...
To identify objective predictive factors for donor after cardiac death (DCD) graft loss and using those factors, develop a recipient stratification risk model that could be used to calculate DCD index (DCD-RI) help in prospective decision making on organ use.The included data from single institute database (2005-2013, n = 261). Univariate survival analysis was followed by adjusted Cox-regressional hazard model. Covariates selected via univariate regression were added the forward selection,...
Extended right hepatectomy (ERH) for hilar cholangiocarcinoma (HCCA) is a complex procedure associated with high risk of postoperative complications. We present case ERH complicated by biliary fistula at the hepatico-jejunostomy site, which led to severe anastomotic stricture. Traditional percutaneous transhepatic drainage repeatedly failed in this case. The stricture was ultimately treated trans-jejunal metal stent insertion, successfully restoring bilio-enteric drainage. A 62-year-old male...
Abstract Background Aorto-hepatic conduits (AHCs) are used for liver allograft revascularisation when the native hepatic artery is unusable. Studies suggest that outcomes with AHCs inferior compared to inflow. Aims This systematic review and meta-analysis assessed based on different inflow sites AHCs. Methods The followed Preferred Reporting Items Systematic Review Meta-Analysis (PRISMA) standards (PROSPERO ID: CRD42024545810). Results Fourteen studies included 32,486 deceased donor...
Abstract Background Biliary reconstruction during liver transplantation (LT) for primary sclerosing cholangitis (PSC) remains debated. A 2015 meta-analysis of 10 studies (1996-2014), found similar biliary stricture (BS) rates duct-to-duct (DD) and Roux-en-Y hepaticojejunostomy (RYH), but higher post-transplant in RYH. This study evaluates DD versus RYH outcomes a contemporary PSC cohort from high-volume centre. Methods Retrospective review all transplants at King's College Hospital between...
Background: Pancreatoduodenectomy with venous resection (PDVR) may be performed to achieve tumour clearance in patients a pancreatic ductal adenocarcinoma (PDAC) involvement. This study aimed evaluate the impact of PDVR on PDAC outcomes. Methods: In total, 435 either R0 status (n = 322) or R1 within superior mesenteric vein groove 113) were extracted from Recurrence After Whipple’s (RAW) dataset. matched 1:2 ratio standard PD patients. Comparisons then made between two groups (surgical...
The outcome of treatment for advanced hepatoblastoma has recently improved after the introduction preoperative or pre- and postoperative cisplatin-containing chemotherapy combined with complete surgical excision. role liver transplantation in a population patients who have received this regimen not been clearly defined.Orthotopic (OLT) was performed 13 children, aged 5 months to 11 years (median 27 months), were assessed unresectable hepatoblastoma, whose pretreatment extent-of-disease based...
The origin of cells replacing ageing β-cells in adult life is unknown. This study assessed the expression classic stem cell markers: Oct4, Sox2 and CD34 islet-enriched fractions versus exocrine cell-enriched from 25 human pancreases following islet isolation. Expression mRNAs was found all samples, with no significant differences between endocrine fractions. Immunohistochemical staining for Sox2, CD133, CD34, CK19, insulin nestin on pancreas sections showed that majority Oct4 +ve were walls...
Shortage of organs for transplantation has led to the renewed interest in donation after circulatory-determination death (DCDD). We conducted a retrospective analysis (2001-2009) and subsequent prospective validation (2010) liver Maastricht-Category-3-DCDD donation-after-brain-death (DBD) offers our program. Accepted declined were compared. DCDD divided into donors who went on cardiac arrest those did not. Donors arrested producing grafts that transplanted or remained unused. Descriptive...
Background and aims The shortage of organs for transplantation has led to increased use procured from donors after cardiac death (DCD). effects on the liver remain poorly understood, however. Using livers obtained DCD versus brain (DBD), we aimed understand how ischemia/reperfusion (I/R) injury alters expression pro-inflammatory markers ceramides influences graft leukocyte infiltration. Methods Hepatocyte inflammation, as assessed by ceramide expression, was evaluated in (n = 13) DBD 10)...
Hepatocellular cancer (HCC) is an established indication for liver transplantation. This group often allocated a donor after cardiac death (DCD) as solution waiting times. There are concerns that this approach may oncologically disadvantage HCC recipients. The aim of study was to determine whether DCD transplantation associated with poorer cancer-related survival in HCC.Study population from single institute (2001-2014) listing diagnosis. Variables related recipient, tumor, and graft were...
The SARS-CoV-2 (COVID-19) pandemic is having a large effect on the management of cancer patients. This study reports approach and outcomes patients receiving radical surgery with curative intent between March September 2020 (in comparison to 2019) in European Institute Oncology, IRCCS (IEO) Milan South East London Cancer Alliance (SELCA). Both institutions implemented COVID-19 minimal pathway where were required self-isolate prior admission swabbed for within 72 h surgery. Positive had...
Primary sclerosing cholangitis (PSC) may reoccur following liver transplantation (LT), and the diagnosis established once imaging studies demonstrate diagnostic cholangiographic appearance. To evaluate whether development of recurrent PSC (rPSC) is associated with cholestasis soon after LT, we studied changes in hepatic biochemistry within first 12 months were linked rPSC graft loss. We conducted a retrospective cohort analysis 158 transplant recipients Canada 549 from United Kingdom....
Abstract Finding specific biomarkers of liver damage in clinical evaluations could increase the pool available organs for transplantation. Lipids are key regulators cell necrosis and hence this study hypothesised that lipid levels be altered suffering severe ischemia. Matched pre- post-transplant biopsies from donation after circulatory death (DCD, n = 36, mean warm ischemia time 21min) brain (DBD, 76, none) were collected. Lipidomic discovery multivariate analysis (MVA) applied. Afterwards,...