A5058565117- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Meningioma and schwannoma management
- Transcranial Magnetic Stimulation Studies
- Cerebrospinal fluid and hydrocephalus
- Genetic Neurodegenerative Diseases
- Glioma Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Vascular Malformations Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Botulinum Toxin and Related Neurological Disorders
- Fetal and Pediatric Neurological Disorders
- Spinal Fractures and Fixation Techniques
- Health and Medical Research Impacts
- Neurofibromatosis and Schwannoma Cases
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Head and Neck Surgical Oncology
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Nerve injury and regeneration
- Epilepsy research and treatment
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Obsessive-Compulsive Spectrum Disorders
Universidade de São Paulo
2004-2024
King's College Hospital NHS Foundation Trust
2019-2023
King's College London
2021-2023
King's College Hospital Charity
2022-2023
Kings Health Partners
2020-2022
King's College Hospital
2020-2022
Universidade de Ribeirão Preto
2018
Saarland University
2018
Universitätsklinikum des Saarlandes
2018
University Medical Center Freiburg
2013-2017
Summary Objectives The aim of this study was to analyze the impact deep brain stimulation ( DBS ) posteromedial hypothalamus pH yp) on seizure frequency in patients with drug‐resistant epilepsy DRE associated intractable aggressive behavior IAB ). Methods Data were collected retrospectively from nine patients, who received bilateral stereotactic yp‐ for treatment medically behavior, focusing five also had . All treated at Colombian Center and Foundation Epilepsy Neurological Diseases— FIRE...
DBS of the medial forebrain bundle (MFB) has been investigated clinically in major depressive disorder patients with rapid and long-term reduction symptoms. In context chronic bilateral high frequency deep brain stimulation (DBS) MFB, current study looked at impact lesioning ascending dopaminergic pathway level ventral tegmental area (VTA). Sprague-Dawley female rats were given injection 6-OHDA into VTA (VTA-lx group) or left unlesioned (control group). Later, all animals received...
Preclinical and clinical evidence suggests that depression might be associated with a dysfunction in the reward/motivation circuitry. Deep brain stimulation (DBS) of superolateral branch medial forebrain bundle (MFB) has been shown recent trial to provide prompt consistent improvement depressive symptoms treatment-resistant patients. In order better understand underlying mechanisms neuromodulation context depression, effects chronic bilateral MFB-DBS were assessed combined rodent model...
Penfield's motor homunculus describes a caricaturised yet useful representation of the map various body parts on pre-central cortex. We propose supplemental clinically represented areas human in cortex and novel subcortical corticospinal tract map. believe this knowledge is essential for safe surgery patients with eloquent brain lesions. A single-institution retrospective cohort study who underwent craniotomy lesions intraoperative neuromonitoring (cortical subcortical) between 2015 2020 was...
The treatment of hydrocephalus in children with endoscopic third ventriculostomy (ETV) has particular features and is associated different success rates (SR). aim this study was to identify putative factors that could influence the outcome ETV children.Clinical data 114 consecutive patients under 18 years age who underwent 116 ETVs from January 2000 2010 were reviewed. Data analyzed regards clinical radiological SR. actual long-term SR compared predicted by Success Score (ETVSS) model.The...
Abstract Background Lesions within the primary motor cortex (M1) and corticospinal tract (CST) represent a significant surgical challenge with delicate functional trade-off that should be integrated in overall patient-centered treatment plan. Methods Patients lesions M1 CST preoperative cortical subcortical mapping (navigated transcranial magnetic stimulation [nTMS] tractography), intraoperative mapping, provisional histologic information (smear without 5-aminolevulinic acid [5-ALA]) were...
Abstract Restorative therapy concepts, such as cell based therapies aim to restitute impaired neurotransmission in neurodegenerative diseases. New strategies enhance grafted survival and integration are still needed improve functional recovery. Anodal direct current stimulation (DCS) promotes neuronal activity secretion of the trophic factor BDNF motor cortex. Transcranial DCS applied cortex transiently improves symptoms Parkinson’s disease (PD) patients. In this proof-of-concept study, we...
Objective . Deep brain stimulation (DBS) of the superolateral branch medial forebrain bundle (MFB) has provided rapid and dramatic reduction depressive symptoms in a clinical trial. Early intracranial self-stimulation experiments MFB suggested detrimental side effects on animals’ health; therefore, current study looked at viability chronic continuous MFB-DBS rodents, with particular attention given to welfare issues identification stimulated pathways. Methods Sprague-Dawley female rats were...
Deep brain stimulation (DBS) is an established treatment for pediatric dystonia. The accuracy of electrode implantation multifactorial and remains a challenge in this age group, mainly due to smaller anatomical targets very young patients compared adults, also abnormalities frequently associated with some etiologies Data on the robot-assisted DBS surgery children are limited. aim current paper was assess leads series childhood-onset