A5013300317- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Glycogen Storage Diseases and Myoclonus
- Neurological disorders and treatments
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Vascular Malformations Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Parkinson's Disease and Spinal Disorders
King's College Hospital NHS Foundation Trust
2019-2022
King's College Hospital
2019
5-Aminolevulic acid-guided surgery (5-ALA-GS) improves the extent of resection (EoR) and progression-free survival in patients with glioblastoma multiforme (GBM).A single-center retrospective cohort study adult GBM who had surgical between 2013 2019, 5-ALA guided versus a non-5-ALA cohort. The primary outcome was overall (OS). Secondary outcomes were EoR, performance status (PS), new focal neurological deficit.Three hundred forty-three included: 253 5-ALA-GS group 90 non-5-ALA-GS group. OS...
Myoclonus describes a movement disorder characterised by brief, abrupt and involuntary contractions of muscles or groups muscles, usually associated with intracranial lesions, limited evidence linking it to spinal pathologies. The pathophysiology myoclonus is extensive multifactorial. Infection, intramedullary extramedullary space-occupying trauma, vascular abnormalities, degenerative processes cervical spondylosis have been implicated the disease, latter stenosis no reported cases an...
The benefits of using 5-aminolevulinic acid (5-ALA) in resection grade IV tumors have been extensively researched. However, few studies investigated the use 5-ALA III gliomas.To discover whether provides significant benefit assisting gliomas.A single-center, retrospective cohort study between January 2013 and 2019 adult patients with gliomas. Patients were separated into a 5-ALA-guided surgery group (5-ALA-GS) non-5-ALA-guided (non-5-ALA-GS). Primary outcome was overall survival (OS);...
Abstract Rationale WHO Grade 3 meningiomas are a rare, malignant subtype of meningioma. Few controlled case series detailing its treatment and follow-up to be found in the literature. Methods Retrospective cohort study patients treated single neuro-oncology centre period between September 2008 March 2019 with an initial diagnosis Demographic clinical data has been collected from available medical records. Results 9 were included this series: 2 had convexity, sphenoid wing, parafalcine, 1...
Abstract Objectives Meningiomas demonstrate specific genetic and epigenetic mutations, whose effect on recurrence progression is still of limited understanding. Single-fraction stereotactic radiosurgery (SRS) an established alternative treatment to surgical resection, proven achieve excellent local disease control with minimal side effects. However, its effects tumorigenesis malignant transformation are uncertain. The published estimated risk ranges from 0.04%-2.6% at 15 years. Design Case...
Arachnoid cysts are CSF-containing entities that rarely symptomatic or warrant neurosurgical intervention. In addition, infection of these lesions is an even rarer event, with only four reports in the literature capturing this. this report, we present case a 79-year-old man presenting paraparesis, secondary to right parasagittal meningioma, incidental asymptomatic sylvian arachnoid cyst (Galassi type II). The initially planned surgery was postponed for 3 months, due COVID-19 restrictions,...