A5060600769- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Spinal Fractures and Fixation Techniques
- COVID-19 and healthcare impacts
- Pelvic and Acetabular Injuries
- Facial Trauma and Fracture Management
- Abdominal Trauma and Injuries
- S100 Proteins and Annexins
- Telemedicine and Telehealth Implementation
- Sepsis Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Sports injuries and prevention
- Sport Psychology and Performance
- Blood Coagulation and Thrombosis Mechanisms
- Vascular Procedures and Complications
- Cardiac Arrest and Resuscitation
- Medical Imaging and Analysis
- Glaucoma and retinal disorders
- Child Abuse and Related Trauma
- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
Birmingham Children's Hospital
2024
University of Birmingham
2021-2024
NIHR Surgical Reconstruction and Microbiology Research Centre
2016-2023
The Edgbaston Hospital
2023
Queen Elizabeth Hospital Birmingham
2016-2022
University Hospitals Birmingham NHS Foundation Trust
2019-2022
Birmingham Dental Hospital
2022
National Institute for Health Research
2016-2022
Institute of Art
2022
Addenbrooke's Hospital
2021
Almost all studies that have investigated the immune response to trauma analysed blood samples acquired post-hospital admission. Thus, we know little of status patients in immediate postinjury phase and how this might influence patient outcomes. The objective study was therefore comprehensively assess ultra-early, within 1-hour, perform an exploratory analysis its relationship with development multiple organ dysfunction syndrome (MODS).The inflammatory 89 adult (mean age 41 years, range...
Primary Objective: Treatment paradigms for traumatic brain injury (TBI) rely on invasive monitoring of intracranial pressure (ICP) planning intervention. Optical pupillometry is a non-invasive, objective method, measuring parameters pupillary response and displaying scalar value – neurological pupil index (NPi). An impaired NPi has been tentatively correlated with ICP, through analysis mean/peak ICP readings. We sought to evaluate this relationship more closely.Research Design: Prospective...
BACKGROUND There is no consensus on reporting nonmortality trauma complications in a graded manner. The Clavien-Dindo scale of was originally for elective surgery and requires adaptation to provide meaningful data patients. In particular, the original score does not account those treated without surgery. We report an adapted (ACDiT) apply it patients managed operatively nonoperatively. METHODS A combined prospective retrospective international multicenter observational study undertaken ACDiT...
There are many questions that remain unanswered regarding outcomes following cranioplasty including the timing of craniectomy as well material used.To establish and evaluate 30-d for all cranial reconstruction procedures in United Kingdom (UK) Ireland through a prospective multicenter cohort study.Patients undergoing insertion or revision between June 1, 2019 November 30, 25 neurosurgical units were included. Data collected include demographics, date indication, date, outcome.In total, 313...
Abstract Traumatic brain injury (TBI) is set to become the leading cause of neurological disability across all age groups. Currently, no reliable biomarkers exist help diagnose severity TBI identify patients who are at risk developing secondary injuries. Thus, discovery for management would improve clinical interventions. Inflammatory markers particularly suited biomarker as leads very early alterations in inflammatory proteins. Using Proseek Multiplex Inflammation assay, we measured that...
Purpose: Cauda equina syndrome (CES) is a spinal emergency with clinical symptoms and signs that have low diagnostic accuracy. National guidelines in the United Kingdom (UK) state all patients should undergo an MRI prior to referral specialist units surgery be performed at earliest opportunity. We aimed evaluate current practice of investigating treating suspected CES UK.Materials Methods: A retrospective, multicentre observational study investigation management was conducted across UK,...
This single-center prospective observational study aims to describe the prevalence of vitamin D deficiency (VDD) in traumatic brain injury (TBI) population and identify any relationship between severity head or quality life. One hundred twenty-four TBI patients had serum (25-OHD) levels measured at local post-TBI endocrine screening clinic over 20 months. Quality Life after Brain Injury questionnaires were completed by patient concurrently. A multivariate regressional analysis was performed,...
In recent conflicts, many UK personnel sustained head injuries requiring damage-control surgery and aeromedical transfer to the UK. This study aims examine indications, complications outcomes of military casualties undergoing craniectomy cranioplasty from conflicts in Afghanistan Iraq.The Joint Theatre Trauma Registry (JTTR) was searched for all survivors Iraq between 2004 2014 resulting trauma.Fourteen decompressive craniectomies cranioplasties were performed with blast gunshot wounds...
Objectives To estimate the prevalence of post-traumatic stress disorder (PTSD) in a large civilian population with traumatic brain injury (TBI), and to assess whether severity is correlated PTSD symptoms. Design Observational, cross-sectional study. Setting participants Outpatient clinic major UK trauma centre secondary care hospital. Estimates are based on 171 sampled individuals attending TBI within an 18-month period. Analysis relationship between was performed subset 127 patients for...
Introduction Assault is the third most common cause of traumatic brain injury (TBI), after falls and road traffic collisions. TBI can lead to multiple long-term physical, cognitive emotional sequelae, including post-traumatic stress disorder (PTSD). Intentional violence may further compound psychological trauma event, in a way that conventional outcome measures, like Glasgow Outcome Scale (GOS), fail capture. This study aims examine influence assault on self-reported outcomes, quality life...
Abstract The Dex-CSDH trial is a randomised, double-blind, placebo-controlled of dexamethasone for patients with symptomatic chronic subdural haematoma. commenced an internal pilot, whose primary objective was to assess the feasibility multi-centre recruitment. Primary outcome data collection and safety were also assessed, whilst maintaining blinding. We aimed recruit 100 from United Kingdom Neurosurgical Units within 12 months. Trial participants randomised 2-week course or placebo in...
Introduction The diagnosis of mild traumatic brain injury or sports-related concussion is a challenge for all clinicians, players, coaches and parents involved in contact sports. Currently, there no validated objective biomarker available to assess the presence severity sport, so it necessary rely on subjective measures like self-reporting symptoms which depend cooperation athlete. There significant health risk associated with repetitive if missed, great value an assist diagnostic prognostic...
Diversion of cerebrospinal fluid (CSF) is a common neurosurgical procedure for control intracranial pressure (ICP) in the acute phase after traumatic brain injury (TBI), where medical management insufficient. CSF can be drained via an external ventricular drain (EVD) or, selected patients, lumbar (external [ELD]) drainage catheter. Considerable variability exists practice on their use. A retrospective service evaluation was completed patients receiving diversion ICP TBI, from April 2015 to...
We test the hypothesis that ventriculoperitoneal (VP) shunt insertion significantly increases contralateral positional plagiocephaly.We reviewed 339 children who had a VP inserted at Birmingham Children's Hospital between 2006 and 2013, noting laterality of frontal or occipital position. ascertained presence post-operative plagiocephaly using cranial vault asymmetry index. Multinomial logistic regression modelling was used to examine relationships plagiocephaly, position, gender age....
Introduction Sport-related concussion management remains a diagnostic dilemma to clinicians in all strata of care, coaching staff and players alike. The lack objective prognostic biomarkers over-reliance on subjective clinical assessments carries significant health risk undiagnosed concussive episodes early return play before full recovery increasing the sustaining additional concussion, leading long-term sequelae and/or unfavourable outcome. Objective To identify set parameters...
A 45-year-old man was dragged behind a car during an alleged assault. He had evidence of head injury and lower limb injury. prehospital pelvic binder applied, he conveyed to major trauma centre. Vital signs on arrival were heart rate 102 bpm, blood pressure 84/65 mm Hg Glasgow Coma Scale (GCS) 11. intubated for decreasing GCS CT scanned following primary survey assessment in accordance with advanced …
Objective To determine how the first wave of COVID-19 pandemic affected outcomes for all operatively managed neurosurgical patients, not only those positive SARS-CoV-2. Design Matched cohort (pairwise method). Setting A single tertiary referral centre at a large UK Major Trauma Centre. Participants During wave, 231 cases were performed. These matched to from 2019. Cases age (±10 years), primary pathology and surgical procedure. excluded analysis if either could be within 10 years, or...
The clay-shoveler’s fracture is a stable oblique through the spinous process of lower cervical vertebra, classically C6 or C7. Diagnosed on plain radiograph, computed tomography and occasionally magnetic resonance imaging, injury most commonly seen in road traffic collisions modern-day. A injury, managed non-operatively requires symptomatic treatment only. This short article examines history surrounding provides comprehensive overview for non-spinal surgeon.
Concussion is a common and potentially debilitating condition. Research has shown that one-third of patients admitted with facial trauma have concurrent concussion. This study aimed to investigate the burden management concussion in presenting acute trauma, identify potential risk factors within this population. A retrospective observational was conducted at UK major centre between 1 January 2019 February2020. One hundred randomly selected who attended clinic responsible for managing were...
Aim To describe the mechanisms, burden of injury, inpatient management and rehabilitation requirements wounded military personnel at UK Role 4 (R4) facility within first 12 months following cessation combat operations in Afghanistan. Methods All aeromedical evacuations were recorded prospectively between October 2014 2015. Demographic, logistical clinical data derived manually from referring medical unit patient movement requests addition to host nation R4 records. Results Ninety-five...