A5071359286- Platelet Disorders and Treatments
- Traumatic Brain Injury Research
- Chronic Lymphocytic Leukemia Research
- Sports injuries and prevention
- Winter Sports Injuries and Performance
- MicroRNA in disease regulation
- RNA Research and Splicing
- Injury Epidemiology and Prevention
- RNA modifications and cancer
- Renal Diseases and Glomerulopathies
- COVID-19 and healthcare impacts
- Autoimmune Bullous Skin Diseases
- Venous Thromboembolism Diagnosis and Management
- Blood groups and transfusion
- Diverse Approaches in Healthcare and Education Studies
- Alzheimer's disease research and treatments
- Blood properties and coagulation
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Complement system in diseases
- SARS-CoV-2 and COVID-19 Research
- Traumatic Brain Injury and Neurovascular Disturbances
University of Birmingham
2016-2024
National Institute for Health Research
2019
Queen Elizabeth Hospital Birmingham
2019
NIHR Surgical Reconstruction and Microbiology Research Centre
2019
Objective To investigate the role of salivary small non-coding RNAs (sncRNAs) in diagnosis sport-related concussion. Methods Saliva was obtained from male professional players top two tiers England’s elite rugby union competition across seasons (2017–2019). Samples were collected preseason 1028 players, and during standardised head injury assessments (HIAs) at three time points (in-game, post-game, 36–48 hours post-game) 156 these. also controls (102 uninjured 66 sustaining a musculoskeletal...
Ibrutinib and acalabrutinib are irreversible inhibitors of Bruton tyrosine kinase used in the treatment B-cell malignancies. They bind irreversibly to cysteine 481 kinase, blocking autophosphorylation on 223 phosphorylation downstream substrates including phospholipase C-γ2. In present study, we demonstrate that concentrations ibrutinib block activity, as shown by loss at C-γ2, delay but do not aggregation response a maximally-effective concentration collagen-related peptide or collagen....
Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations inhibitor ibrutinib block CLEC-2-mediated activation and phosphorylation including Syk PLCγ2 in human platelets. Activation is also blocked patients with X-linked agammaglobulinemia (XLA) caused by a deficiency or absence Btk. contrast, response to GPVI delayed presence XLA, preserved. A similar set results seen second-generation inhibitor, acalabrutinib. The...
Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms human platelet activation by E. leading thrombus formation are poorly understood. While the IgG receptor FcγRIIA has a key role response various Gram-positive species, its bacteria is defined. This study aimed investigate molecular coli, including...
Alzheimer’s disease (AD) is the most common form of dementia globally; however, aetiology AD remains elusive hindering development effective therapeutics. MicroRNAs (miRNAs) are regulators gene expression and have been growing interest in recent studies many pathologies including not only for their use as biomarkers but also implications therapeutic field. In this study, miRNA protein profiles were obtained from brain tissues different stage (Braak III-IV Braak V-VI) patients compared to...
Introduction The diagnosis of mild traumatic brain injury or sports-related concussion is a challenge for all clinicians, players, coaches and parents involved in contact sports. Currently, there no validated objective biomarker available to assess the presence severity sport, so it necessary rely on subjective measures like self-reporting symptoms which depend cooperation athlete. There significant health risk associated with repetitive if missed, great value an assist diagnostic prognostic...
Introduction Sport-related concussion management remains a diagnostic dilemma to clinicians in all strata of care, coaching staff and players alike. The lack objective prognostic biomarkers over-reliance on subjective clinical assessments carries significant health risk undiagnosed concussive episodes early return play before full recovery increasing the sustaining additional concussion, leading long-term sequelae and/or unfavourable outcome. Objective To identify set parameters...
<h3>Objective</h3> To investigate the association of acute-phase non-invasive salivary biomarkers with sport-related concussion (SRC) in professional men's rugby. <h3>Design</h3> Prospective cohort study. <h3>Setting</h3> England's Premiership and Championship rugby clubs. <h3>Participants</h3> Twenty-two out twenty-four clubs participated across 2 seasons (2017/18 2018/19). 1028 subjects were recruited, whom 391 went on to be included as either concussed or matched controls under World...
<h3>Objective</h3> Explore the correlation between number of head impacts sustained in amateur boxing sparring and expression salivary microRNAs. <h3>Design</h3> Observational, cross sectional study. <h3>Setting</h3> Saliva samples collected immediately before after bouts elite male boxers. <h3>Participants</h3> 6 boxers, aged 20 27 years. <h3>Interventions (or Assessment Risk Factors)</h3> <b>Outcome Measures:</b> Video footage sessions was used to record punches type impact. Data on...