A5076777946- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Hormonal and reproductive studies
- Trauma and Emergency Care Studies
- Traumatic Brain Injury Research
- Respiratory Support and Mechanisms
- Electrolyte and hormonal disorders
- Thermal Regulation in Medicine
- Traumatic Brain Injury and Neurovascular Disturbances
- Occupational Health and Performance
- Nutrition and Health in Aging
- Winter Sports Injuries and Performance
- Thermoregulation and physiological responses
- Intensive Care Unit Cognitive Disorders
- Sports injuries and prevention
- Health and Well-being Studies
- Muscle metabolism and nutrition
- High Altitude and Hypoxia
- Poisoning and overdose treatments
- Global Health and Surgery
- Adrenal Hormones and Disorders
- Spaceflight effects on biology
- Pregnancy-related medical research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
NIHR Surgical Reconstruction and Microbiology Research Centre
2014-2024
University Hospitals Birmingham NHS Foundation Trust
2014-2024
Queen Elizabeth Hospital Birmingham
2014-2023
University of Birmingham
2019-2023
National Institute for Health Research
2019-2023
Royal Victoria Hospital
2019-2020
University of Ulster
2019-2020
Government of the United Kingdom
2019
Queen Elizabeth Hospital
2019
Loughborough University
2011
Objective To investigate the role of salivary small non-coding RNAs (sncRNAs) in diagnosis sport-related concussion. Methods Saliva was obtained from male professional players top two tiers England’s elite rugby union competition across seasons (2017–2019). Samples were collected preseason 1028 players, and during standardised head injury assessments (HIAs) at three time points (in-game, post-game, 36–48 hours post-game) 156 these. also controls (102 uninjured 66 sustaining a musculoskeletal...
Understanding the nutritional demands on serving military personnel is critical to inform training schedules and dietary provision. Troops deployed Afghanistan face austere living working environments. Observations from those reported in British US media indicated possible physical degradation of Afghanistan. Therefore, present study aimed investigate changes body composition status how these were related fitness. In a cohort Royal Marines ( n 249) for 6 months, size estimated mass, height,...
Survival rates after severe injury are improving, but complication and outcomes variable.
Traumatic injury elicits a hyperinflammatory response and remodelling of the immune system leading to immuneparesis. This study aimed evaluate whether traumatic results in state prematurely aged phenotype relate this clinical outcomes greater risk developing additional morbidities post-injury.
Abstract The immune response to major trauma has been analysed mainly within post-hospital admission settings where the inflammatory is already underway and early drivers of clinical outcome cannot be readily determined. Thus, there a need better understand immediate injury how this might influence important patient outcomes such as multi-organ dysfunction syndrome (MODS). In study, we have assessed in 61 patients at three different post-injury time points (ultra-early (<=1 h), 4–12 h,...
Trauma-induced steroid changes have been studied post-hospital admission, resulting in a lack of understanding the speed and extent immediate endocrine response to injury. The Golden Hour study was designed capture ultra-acute traumatic injury.We conducted an observational cohort including adult male trauma patients <60 years, with blood samples drawn ≤1 h major by pre-hospital emergency responders.We recruited 31 (mean age 28 [range 19-59] years) mean injury severity score (ISS) 16 (IQR...
Abstract Soldier operational performance is determined by their fitness, nutritional status, quality of rest/recovery, and remaining injury/illness free. Understanding large fluctuations in status during operations critical to safeguarding health well-being. There are limited data world-wide describing the effect extreme climate change on nutrient profiles. This study investigated hot-dry deployments vitamin D (assessed from 25-hydroxyvitamin (25(OH)D) concentration) young, male, military...
Introduction The diagnosis of mild traumatic brain injury or sports-related concussion is a challenge for all clinicians, players, coaches and parents involved in contact sports. Currently, there no validated objective biomarker available to assess the presence severity sport, so it necessary rely on subjective measures like self-reporting symptoms which depend cooperation athlete. There significant health risk associated with repetitive if missed, great value an assist diagnostic prognostic...
Recent advances in emergency medicine and the co-ordinated delivery of trauma care mean more critically-injured patients now reach hospital alive survive life-saving operations. Indeed, between 2008 2017, odds surviving a major traumatic injury UK increased by nineteen percent. However, improved survival rates severely-injured have placed an burden on healthcare system, with common cause intensive unit (ICU) admissions that last ≥10 days. Improved understanding factors influencing patient...
Introduction Sport-related concussion management remains a diagnostic dilemma to clinicians in all strata of care, coaching staff and players alike. The lack objective prognostic biomarkers over-reliance on subjective clinical assessments carries significant health risk undiagnosed concussive episodes early return play before full recovery increasing the sustaining additional concussion, leading long-term sequelae and/or unfavourable outcome. Objective To identify set parameters...
Polar expeditions have been associated with changes in the hypothalamic-pituitary-testicular axis consistent central hypogonadism (i.e., decreased testosterone, luteinising hormone (LH), and follicle stimulating (FSH)). These are typically body mass loss. Our aim was to evaluate whether maintenance of during a polar expedition could mitigate against development hypogonadism. Male participants (n = 22) from 42-day (British Services Antarctic Expedition 2012) volunteered take part study. Body...
<h3>Objective</h3> To investigate the association of acute-phase non-invasive salivary biomarkers with sport-related concussion (SRC) in professional men's rugby. <h3>Design</h3> Prospective cohort study. <h3>Setting</h3> England's Premiership and Championship rugby clubs. <h3>Participants</h3> Twenty-two out twenty-four clubs participated across 2 seasons (2017/18 2018/19). 1028 subjects were recruited, whom 391 went on to be included as either concussed or matched controls under World...
Introduction The improvements in short-term outcome after severe trauma achieved through early resuscitation and acute care can be offset over the following weeks by an systemic inflammatory response with immuneparesis leading to infection, multiorgan dysfunction/multiorgan failure (MOF) death. Serum levels of androgen precursor dehydroepiandrosterone (DHEA) its sulfate ester DHEAS, steroids immune-enhancing activity, are low traumatic injury at a time when patients catabolic...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Context Survival rates after severe injury are improving, but complication and outcomes variable. Objective This cohort study addressed the lack of longitudinal data on steroid response to major trauma during recovery. Design We undertook a prospective, observational from time six months post-injury at UK centre military rehabilitation unit, studying patients within 24 hours (estimated New Injury Severity Score (NISS) >15). Main outcome measures measured adrenal gonadal steroids...
Background: Survival rates after severe injury are improving, but complication and outcomes variable. This study addressed the lack of data on endocrine response, particularly adrenal steroid secretion, during recovery from major trauma, exploring potential targets for intervention.Methods: We undertook a prospective, observational cohort time to six months post-injury at UK trauma centre military rehabilitation unit, studying patients within 24 hours (estimated New Injury Severity Score...
Background: Survival rates after severe injury are improving, but complication and outcomes variable. This study addressed the lack of data on adrenal gonadal steroid response during recovery from major trauma in relation to clinical outcomes, exploring potential targets for future intervention.Methods: We undertook a prospective, observational cohort at UK centre military rehabilitation unit, studying patients within 24 hours (estimated New Injury Severity Score (NISS) >15) regular...
Background. Personal protective equipment (PPE) is worn by military personnel to protect from combat trauma. War films may not represent PPE accurately, even when considered realistic. There a risk that the subtle influence of subvert understanding amongst and civilians. Methods. An observational study compared depiction within popular war real-life. Films were included if they depicted land-based warfare. Depiction helmets, body armour, eye protection, gloves, boots hearing protection was...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
The inclusion of British Service Personnel (SP) lacking capacity into research studies from the point injury through to medium-term rehabilitation had not previously been undertaken until work support operations in Afghanistan (2001–2014). Surgeon General’s Casualty Nutrition Study and Steroids Immunity Injury Rehabilitation sought address nutrition, endocrine immune responses a military patient cohort. A fundamental part is feedback patients, their relatives ward staff on data collection...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)