A5066855601- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Traumatic Brain Injury Research
- Laser Applications in Dentistry and Medicine
- Optical Imaging and Spectroscopy Techniques
- Medical Imaging and Analysis
- Immune Cell Function and Interaction
- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Fetal and Pediatric Neurological Disorders
- Cancer Genomics and Diagnostics
- Intracerebral and Subarachnoid Hemorrhage Research
- Head and Neck Surgical Oncology
- Biomedical Ethics and Regulation
- T-cell and B-cell Immunology
- S100 Proteins and Annexins
- Coronary Artery Anomalies
- Human-Animal Interaction Studies
- Spine and Intervertebral Disc Pathology
- Spinal Dysraphism and Malformations
- Vascular Anomalies and Treatments
- Cardiac Arrest and Resuscitation
University of Birmingham
2019-2025
NIHR Surgical Reconstruction and Microbiology Research Centre
2019-2025
Queen Elizabeth Hospital Birmingham
2019-2025
University Hospitals Birmingham NHS Foundation Trust
2021-2024
Fred Hutch Cancer Center
2023-2024
The Edgbaston Hospital
2023
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2023
Cancer Research Center
2023
Birmingham Dental Hospital
2022
National Institute for Health Research
2022
Background The paucity of tumor-specific targets for chimeric antigen receptor (CAR) T-cell therapy solid tumors necessitates careful preclinical evaluation the therapeutic window candidate antigens. Human epidermal growth factor 2 (HER2) is an attractive CAR in humans but has potential eliciting on-target off-tumor toxicity. We developed immunocompetent tumor model targeting murine HER2 (mHER2) and examined effect affinity, dose, lymphodepletion on safety efficacy. Methods Antibodies...
Traumatic injury to the brain and spinal cord (neurotrauma) is a common event across populations often causes profound irreversible disability. Pathophysiological responses trauma exacerbate damage of an index injury, propagating loss function that central nervous system (CNS) cannot repair after initial resolved. The way in which lost consequence complex array mechanisms continue chronic phase post-injury prevent effective neural repair. This review summarises events traumatic (TBI) (SCI),...
The interaction of the tumor necrosis factor receptor (TNFR) family member CD27 on naive CD8+ T (Tn) cells with homotrimeric CD70 antigen-presenting (APCs) is necessary for cell memory fate determination. Here, we examined signaling during Tn activation and differentiation. In conjunction (TCR) stimulation, ligation by a synthetic trimeric ligand triggered internalization degradation, suggesting active regulation this axis. Internalized recruited adaptor TRAF2 phosphatase SHP-1, thereby...
Abstract Spinal cord injury (SCI) is a significant cause of lifelong disability, with no available disease-modifying treatments to promote neuroprotection and axon regeneration after injury. Photobiomodulation (PBM) promising therapy which has proven effective at restoring lost function SCI in pre-clinical models. However, the precise mechanism action yet be determined. Here, we used an in-vivo model adult rats that received daily PBM (660 nm, 24 mW/cm 2 , 1 min) three days post-injury,...
Primary Objective: Treatment paradigms for traumatic brain injury (TBI) rely on invasive monitoring of intracranial pressure (ICP) planning intervention. Optical pupillometry is a non-invasive, objective method, measuring parameters pupillary response and displaying scalar value – neurological pupil index (NPi). An impaired NPi has been tentatively correlated with ICP, through analysis mean/peak ICP readings. We sought to evaluate this relationship more closely.Research Design: Prospective...
Abstract Spinal cord injury (SCI) is a cause of profound and irreversible damage, with no effective therapy to promote functional recovery. Photobiomodulation (PBM) may provide viable therapeutic approach using red or near‐infrared light recovery after SCI by mitigating neuroinflammation preventing neuronal apoptosis. Our current study aimed optimize PBM dose regimens develop validate the efficacy an invasive delivery paradigm for SCI. Dose optimization studies were performed serum...
The goal was to predict pressure reactivity index (PRx) using non-invasive transcranial Doppler (TCD) based indices of cerebrovascular reactivity, systolic flow (Sx_a), and mean (Mx_a). Continuous extended duration time series recordings middle cerebral artery blood velocity (CBFV) were obtained robotic TCD in parallel with direct intracranial (ICP). PRx, Sx_a, Mx_a derived from high frequency archived signals. Using time-series techniques, autoregressive integrative moving average (ARIMA)...
Apoptotic cell death within the brain represents a significant contributing factor to impaired post-traumatic tissue function and poor clinical outcome after traumatic injury. After irradiation with light in wavelength range of 600–1200 nm (photobiomodulation), previous investigations have reported reduction apoptosis various tissues. This study investigates effect 660 photobiomodulation on organotypic slice cultured hippocampal rats, examining apoptotic loss. Tissue optical Raman...
The variation of the pressure in cisterna magna after raising or lowering arterial pressure, has been recorded dogs. When systemic is low (under 50 mm Hg carotid artery), pulsations CSF present a morphology type. When, on other hand, high (above 200 Hg) cisternal venous mixed detailed studies these morphologies are now under way. circulatory respiratory parameters (venous pCO2) cannot be evaluated experiments.
Although neurons in the adult mammalian CNS are inherently incapable of regeneration after injury, we previously showed that exogenous delivery pigment epithelium-derived factor (PEDF), a 50-kDa neurotrophic (NTF), promoted retinal ganglion cell neuroprotection and axon regeneration. Here, show PEDF other elements pathway highly upregulated dorsal root (DRGN) from regenerating column (DC) injury paradigms when compared with non-regenerating DC models. Exogenous was neuroprotective to DRGN...
Post-concussion Syndrome (PCS) describes persistent nonspecific neurological, cognitive and emotional symptoms following concussion. A young male presented to a sports concussion clinic with post-injury. Neurocognitive testing found unexpected severe memory impairment. Blood tests for pituitary function returned low cortisol levels secondary adrenal insufficiency (AI), which was immediately treated. Post-treatment improvement of levels, repeat neuropsychology demonstrated reliable in...
Diversion of cerebrospinal fluid (CSF) is a common neurosurgical procedure for control intracranial pressure (ICP) in the acute phase after traumatic brain injury (TBI), where medical management insufficient. CSF can be drained via an external ventricular drain (EVD) or, selected patients, lumbar (external [ELD]) drainage catheter. Considerable variability exists practice on their use. A retrospective service evaluation was completed patients receiving diversion ICP TBI, from April 2015 to...
Results ICPM was undertaken for a number of different conditions including undiagnosed headache (20.4%), IIH (28.7%), NPH (5.3%), high-pressure hydrocephalus (eg congenital/ post-traumatic/post-SAH) (17.2%) and Chiari malformations/syringomyelia (13.6%). Indications included (74.0%), visual disturbance (6.2%), gait (6.2%) cognitive (5.0%). Mean monitoring time 37.3 hrs (range 12-154 hrs). Monitoring conducted in the presence CSF shunt (50.6%), venous stent (3.7%) previous cranial...
Chiari malformation (CM) describes cerebellar tonsillar descent below the level of foramen magnum. It is commonly associated with syringomyelia and often presents headache (1). The conventional surgical treatment for symptomatic patients magnum decompression (FMD) (2) which carries a significant burden operative morbidity (3). Altered cerebrospinal fluid (CSF) dynamics have been demonstrated in CM CSF diversion has used as an alternative modality. Patients chronic radiological evidence...
Selecting probable idiopathic normal pressure hydrocephalus (INPH) patients for shunt insertion presents a challenge because of coexisting comorbidities and other conditions that could mimic NPH. The characteristic appearance DESH (Disproportionately Enlarged Subarachnoid Space Hydrocephalus) on brain imaging has been shown to have high positive predictive value in identifying responsive INPH (SINPHONI trial). However, the negative this radiological sign was not clearly demonstrated.
Introduction Diversion of cerebrospinal fluid (CSF) in a traumatic brain injury (TBI) is an established means for achieving control intracranial pressure (ICP), aimed at improving homeostasis. The literature and anecdotal reports suggest variation practice between neurosurgical centres internationally, with current guidelines advocating ventricular drainage over lumbar drainage. We sought to establish the United Kingdom regarding methods ICP TBI. Methods A 20-point survey was distributed...